Anti-CMV IgM titer predicts CMV disease after liver transplantation.
Among 19 liver transplant recipients who developed CMV disease, 18 had high CMV-specific IgM antibody levels as measured by automated AxSYM assay. IgM was detected before CMV DNA (by PCR) in 2 patients, with both tests concurrently positive in 7 patients. DNA was detected before IgM in 8 patients. In addition, AxSYM results were positive in 11 of 21 patients without evidence of CMV disease, with all of these patients also positive for CMV DNA. Maximum IgM titer was a predictor of CMV disease independent of methylprednisolone use and donor and recipient serostatus, though viral load remained a significant independent risk factor for disease.
The researchers concluded that analyzing liver transplant recipients by both PCR and AxSYM assay may produce complimentary results. (Journal of Infectious Disease 2000;182:1610-1615.)
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|Title Annotation:||Royal Free and University College Medical School study cytomegalovirus|
|Comment:||Anti-CMV IgM titer predicts CMV disease after liver transplantation.(Royal Free and University College Medical School study cytomegalovirus)|
|Article Type:||Brief Article|
|Date:||Dec 15, 2000|
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