Printer Friendly

Angiotensin-converting enzyme inhibitors as a cause of isolated angioedema in a Slovenian population.

Introduction

Angioedema (AE) is a localized swelling of the subcutaneous tissue and/or submucosa. A sudden local increase in the permeability of capillaries and post-capillary venules causes a fluid shift from plasma to interstitium. A number of mediators can increase microvascular permeability; for example, histamine, arachidonic acid metabolites (prostaglandins, leukotrienes), and bradykinin. Based on the physiological mechanism, AE is divided into two major groups: mastocyte-mediator-induced AE (histaminergic AE) and bradykinin-induced AE (1).

Episodes of swelling develop in minutes to hours (1). The skin over the AE may be erythematous or have a normal skin color. AE may be painful. Pruritus is rarely present (2). When AE is not accompanied by urticaria it is called isolated AE (3). AE most frequently involves the tongue, lips, face, and, less frequently, the extremities, genitalia, or intestines (4). When AE involves the tongue or larynx, it is a life-threatening condition due to the risk of suffocation (5). In many patients, the etiology of AE is remains unknown and a diagnosis of idiopathic AE (IAE) is made (4).

In this report, we present data on the frequency of the causes and severity of isolated AE in patients attending a tertiary clinic. We aimed to identify how often AE is associated with angiotensin-converting enzyme inhibitor (ACEI-AE) therapy and whether the severity of AE episodes in these patients differs from the severity of idiopathic AE.

Patients and methods

Patients

We included patients with AE that were referred to a tertiary allergy clinic from 2005 to 2014. Using the hospital information system, we identified patients with a diagnosis of T78.3 according to ICD-10 (angioneurotic edema). We thoroughly examined patient medical records using a data-collection form for data on concomitant urticaria, other diagnoses that could explain edema, locations of angioedema, treatment of episodes (location and medicines used), atopy, and concomitant medications. We grouped patients as shown in Figure 1. First, we excluded patients that had AE in the course of urticaria or anaphylaxis. Then we separated patients with isolated AE due to identified causes (i.e., hereditary AE, allergy, autoimmune diseases, histamine intolerance, AE of the uvula in patients with gastroesophageal reflux, and labial edema due to viral infections). Patients with no identified cause that were not receiving ACEI were regarded as IAE. We contacted patients that were receiving ACEI at the time of AE presentation by mail, explained the aim of the study, and asked them for permission to participate in a structured phone interview to obtain follow-up data on the effect of ACEI discontinuation. If AE did not occur 3 or more months after ACEI discontinuation, the patient was classified as ACEI-AE. Patients that did not respond to our invitation and those whose telephone numbers and e-mail addresses were not available were excluded from some parts of the analysis (comparison of characteristics of ACEI-induced AE vs. IAE).

AE characteristics

We obtained the data on AE location from patient medical files. AE severity was graded as mild (discomfort with no effect on daily activities), moderate (discomfort with an effect on daily activities), and severe (unable to perform daily activities or regular work). Treatment of the most severe episode anytime in the patient's history was graded as: 1 = did not seek medical attention at the time of AE symptoms; 2 = sought medical attention from the family physician or emergency department; and 3 = hospitalization. The number of AE episodes in life was graded as 1 (1 or 2 AE episodes), 2 (3 to 10 AE episodes), and 3 (more than 10 episodes).

Statistical methods

Data are presented as the mean and standard deviation. The statistical significance in the frequency of location of IAE and ACEIAE and associated signs and symptoms among the groups of patients were analyzed with Fisher's exact test.

Confidence intervals (CIs) were calculated as exact CIs for sample proportions. We took a more conservative approach (a wider CI) and calculated it only for patients that had a well-characterized origin of angioedema.

Ethical approval

The study was approved by the national ethics committee on February 18th, 2014.

Results

Proportion of types of AE

In the 10-year period from 2005 to 2014, 603 patients with AE were referred (59.9% women) to our clinic. Among them, 36.9% of AE was associated with urticaria or anaphylaxis, and 10.5% of patients were diagnosed with other identified causes (Fig. 1). Of the remaining, 170 were receiving ACEI, 134 were not receiving ACEI, and for 37 patients there were no data on ACEI in the medical file. Finally, 80 patients were diagnosed as ACEI-AE and 177 with IAE. For 84 patients, we did not have follow-up data (47 of these were treated with ACEI, and for 37 there were no data on ACEI treatment).

To estimate the proportion of ACEI-AE in the cohort of isolated AE, we further analyzed 304 patients with a known ACEI treatment status. We first assessed a sample of ACEI-AE cases among patients with well-characterized origin of AE among patients taking ACEI. The proportion of ACEI-AE among these was 80/125 (64%; 95% CI = 54.9%-72.4%). We then extrapolated this number to a sample of patients that were taking ACE inhibitors but in which we could not characterize the origin of AE, thus obtaining an additional 30 patients that were probably suffering from ACEIAE in the entire group of patients. This allowed us to evaluate the proportion of ACEI-AE in the entire sample (110/304 [36.2%]). The 95% CI was 30.3% to 42.4%.

[FIGURE 1 OMITTED]

Characteristics of ACEI-AE and IA

There was a significant difference between IA and ACEI-AE in the age and sex distributions (Table 1). IA was more common in women than in men, and ACEI-AE was equally distributed between sexes. The presence of atopy was not significantly different between the groups (IA 37.9% and ACEI-AE 26.2%). The location of AE did not significantly differ between IA and ACEI-AE, although there was a tendency for a higher risk of oral cavity AE in ACEI-AE (Table 2). Significantly more patients with ACEI-AE complained of dyspnea (32 of 80; 40.0%) compared to IA (39 of 177; 22.0%; p < 0.01). The number, severity, and treatment of AE episodes are shown in Table 3. The number of episodes until referral to the clinic was not significantly different between IA and ACEI-AE; however, patients with ACEI-AE had more severe episodes compared to IA, and those episodes were more likely to be treated by a family doctor or patients were even hospitalized.

Discussion

We found that between 27.1% and 37.9% of the isolated AE cases in everyday clinical practice at the tertiary allergy clinic were due to ACEI, and 54.9% to 72.4% of AE in patients that were treated with ACEI had ACEI-AE. In spite of an extensive diagnostic workup and growing knowledge about the pathophysiology of AE, other specific causes of AE are rarely identified, and more than half of isolated AE remains idiopathic (6).

Atopy does not seem to be an important factor in the pathogenesis of isolated AE, as shown in our study. The sex distribution, age, frequency of signs, symptoms, and locations of AE found in our study were similar to reports in the literature (4, 6). In a study by Zingale et al., the face was involved in 81% of patients, the tongue and oral cavity in 45%, other cutaneous sites in 17%, upper airways in 20%, and the bowel in 3% of patients.

Angiotensin-converting enzyme (ACE) catalyzes conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Inhibition of ACE with ACEI decreases the production of angiotensin II and thus lowers blood pressure. However, ACE is the main enzyme that is also responsible for the degradation of bradykinin. Although bradykinin is degraded by other peptidases--for example, aminopeptidases M, carboxypeptidases N, neutral endopeptidases, dipeptidyl peptidase IV, enkephalinases, or neprilysin--these enzymes are less effective than ACE (7). In susceptible individuals taking ACEI, alternative pathways for bradykinin degradation are less active, which in turn causes episodic accumulation of bradykinin and subsequently cough or AE (8). Risk of AE is increased in patients with certain polymorphisms. The insertion II genotype of insertion/deletion (I/D) ACE polymorphism is associated with low circulating ACE levels (9). Patients with C-2399A polymorphism have reduced activity of aminopeptidase P and a higher incidence of ACEI-AE. Because the gene is X-linked, it explains a higher frequency of ACEI-AE in women, as found in some studies. The bradykinin receptor B2R-9 allele has higher affinity for bradykinin and was associated with more severe episodes in cases of hereditary AE due to C1NH deficiency (9). Substance P, which is also degraded by ACE, and additionally by neutral endopeptidases, can contribute to AE by increasing vascular permeability (10).

Up to 5% of patients do not tolerate ACEI, primarily due to cough, and AE occurs in 0.1% to 0.7% of patients taking ACEI (11). In a meta-analysis of 40 randomized controlled trials with 74,857 patients, AE occurred in 0.3% of patients receiving ACEI and in 0.11% of patients receiving angiotensin receptor blockers or placebo (12).

ACEI is a frequently used medication for hypertension, chronic heart failure, ischemic heart disease, diabetic nephropathy, and progressive renal failure. In the last few years, use of ACEI has increased substantially (13). In Slovenia, between 2003 and 2013, ACEI use has increased by 47.6% (14). Parallel with increased ACEI prescription, increased frequency of AE has also been no ticed (15, 16). Holm and Ovesen showed a three-fold increase in ACE use from 2000 to 2009, and a 69% higher incidence in ACEI-AE in 2005-2009 compared to 2000-2004 (13).

AE usually manifests soon after initiating ACEI therapy, but can also manifest only after years of therapy (4). Our patients were diagnosed with ACEI-AE after a median of three to 10 episodes. IAE is more frequent in women than in men, as also shown in our study (4). However, in ACEI-AE, we found no difference in the sex distribution, as was also the case in the study of patients hospitalized for ACEI-AE (17). Patients with ACEI-AE are significantly older than patients with IAE, which can be explained by the fact that an ACEI is prescribed in advanced age.

ACEI-AE is more severe than IA, as also shown in our study. ACEI-AE is a potentially life-threatening condition (17, 18). In the United States, mortality due to AE increased in the last 30 years from 0.24 to 0.34 per million in spite of decreasing mortality due to hereditary AE (19). It is likely that the prevalence of life-threatening episodes is much higher than reported. In a 1-year period, we recognized two severe episodes with a need for intubation in a single Slovenian regional hospital (20). The frequency and severity of ACEI-AE was higher in African-Americans (21). It is believed that the tendency is genetically determined and related to polymorphic variants in genes that modulate the activity of aminopeptidases (22).

In our study, one-third of AE patients had ACEI therapy at presentation. Among these AE patients, approximately two-thirds no-longer had AE episodes after ACEI discontinuation, but in the rest AE episodes continued, which means that ACEI therapy was not the main reason for AE but was only an aggravating factor.

No specific drugs are licensed for the treatment of ACEI-AE. The majority of patients are treated with antihistamines and systemic steroids. Epinephrine is not very effective in ACEI-AE. Some recent studies showed a much higher efficacy of icatibant. Icatibant is currently licensed only for treatment of patients with hereditary AE (23-25). Omalizumab was also shown to be effective in refractory IA (26).

There are some weaknesses in our study. It was predominantly retrospective and a single-center study. Only patients that had data on ACEI therapy in their medical chart and with a confirmed diagnosis were contacted. We were not able to contact all patients with a history of ACEI treatment. This approach might underestimate the number of patients with identified causes of AE (apart from ACEI).

In conclusion, ACEI treatment was shown to be the most frequent removable cause of isolated AE. About two-thirds of AE cases in patients taking ACEI are resolved after removal of the drug.

doi: 10.15570/actaapa.2016.1

Received: 24 October 2015 | Returned for modification: 30 November 2015 | Accepted: 24 December 2015

Acknowledgement

We thank Eva Cafuta for help with data collection and Julij Selb for statistical analysis. The authors declare no competing interests.

References

(1.) Bas M, Adams V, Suvorava T, Niehues T, Hoffmann TK, Kojda G. Nonallergic angioedema: role of bradykinin. Allergy. 2007; 62:842-56.

(2.) Kaplan AP, Greaves MW. Angioedema. J Am Acad Dermatol. 2005; 53:373-88.

(3.) Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014; 133:1270-7.

(4.) Zingale LC, Beltrami L, Zanichelli A, Maggioni L, Pappalardo E, Cicardi B, et al. Angioedema without urticaria: a large clinical survey. CMAJ. 2006; 175:1065-70.

(5.) Kim SJ, Brooks JC, Sheikh J, Kaplan MS, Goldberg BJ. Angioedema deaths in the United States, 1979-2010. Ann Allergy Asthma Immunol. 2014; 113:630-4.

(6.) Levy J, Rivard GE, Wagner E, Beezhold D, Berlin N, Fan L, et al. Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema. Allergy Asthma Clin Immunol. 2014; 10:60.

(7.) Campo P, Fernandez TD, Canto G, Mayorga C. Angioedema induced by angiotensin-converting enzyme inhibitors. Curr Opin Allergy Clin Immunol. 2013; 13:337-44.

(8.) Brugts JJ, Arima H, Remme W, Bertrand M, Ferrari R, Fox K, et al. The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease. Int J Cardiol. 2014; 20:718-23.

(9.) Hoover T1, Lippmann M, Grouzmann E, Marceau F, Herscu P. Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors. Clin Exp Allergy. 2010; 40:50-61.

(10.) Kostis JB, Packer M, Black HR, Schmieder R, Henry D, Levy E. Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs Enalapril (OCTAVE) trial. Am J Hypertens. 2004; 17:103-11.

(11.) Sabroe RA, Black AK. Angiotensin-converting enzyme (ACE) inhibitors and angio-oedema. Br J Dermatol. 1997; 136:153-8.

(12.) Makani H, Messerli FH, Romero J, Wever-Pinzon O, Korniyenko A, Berrios RS, et al. Meta-analysis of randomized trials of angioedema as an adverse event of reninangiotensin system inhibitors. Am J Cardiol. 2012; 110:383-91.

(13.) Holm JP, Ovesen T. Increasing rate of angiotensin-converting enzyme inhibitor-related upper airway angio-oedema. Dan Med J. 2012; 59:A4449.

(14.) Podatki o porabi zdravil [Data on therapeutic drug use] [Internet]. Zavod za zdravstveno zavarovanje Slovenija. [cited 2015 Oct 15]. Available from: https://partner.zzzs.si/wps/portal/portali/aizv/zdravila_in_zivila_za_ posebne_zdravstvene_namene/podatki_o_porabi_zdravil/!ut/p/b1/04_ Sj9CPykssy0xPLMnMz0vMAfGjzOJNDF093Y39DTwt3MJcDDyDnD183by- 9jA0CDYEKIoEKzAx8HT08DQw9LEy8HA08Tc18TM1NLY0MDAwJ6ffSj0rPyU8CWhWuH4VfsRFUAT7LwAoMcABHA30_j_zcVP2C3IjKYE9dRwBz0b4C/dl4/ d5/L2dJQSEvUUt3QS80SmtFL1o2XzQxRUlHM08wSTg4UzEwQTJCNzZMT0U-wODQw/. Slovene.

(15.) Roberts JR, Lee JJ, Marthers DA. Angiotensin-converting enzyme (ACE) inhibitor angioedema: the silent epidemic. Am J Cardiol. 2012; 109:774-5.

(16.) Rasmussen ER, Mey K, Bygum A. Angiotensin-converting enzyme inhibitor-induced angioedema-a dangerous new epidemic. Acta Derm Venereol. 2014; 94: 260-4.

(17.) Gang C, Lindsell CJ, Moellman J, Sublett W, Hart K, Collins S, et al. Factors associated with hospitalization of patients with angiotensin-converting enzyme inhibitor-induced angioedema. Allergy Asthma Proc. 2013; 34:267-73.

(18.) Banerji A, Clark S, Blanda M, LoVecchio F, Snyder B, Camargo CA. Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department. Ann Allergy Asthma Immunol. 2008; 100:327-32.

(19.) Kim SJ, Brooks JC, Sheikh J, Kaplan MS, Goldberg BJ. Angioedema deaths in the United States, 1979-2010. Ann Allergy Asthma Immunol. 2014; 113:630-4.

(20.) Rupnik E, Kariz S, Iglic C, Zidarn M, Kosnik M. Zivljenje ogrozajoc angioedem po zaviralcu angiotenzinove konvertaze: prikaz dveh primerov [Life-threatening angioedema induced by angiotensin-converting enzyme inhibitor: two case reports]. Zdr Vestn. 2015; 84:12. Slovene.

(21.) Gainer JV, Nadeau JH, Ryder D, Brown NJ. Increased sensitivity to bradykinin among African Americans. J Allergy Clin Immunol. 1996; 98:283-7.

(22.) Mahmoudpour SH, Leusink M, van der Putten L, Terreehorst I, Asselbergs FW, de Boer A, et al. Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis. Pharmacogenomics. 2013; 14:249-60.

(23.) Ba$ M, Greve J, Stelter K, Havel M, Strassen U, Rotter N, et al. A randomized trial of icatibant in ACE-inhibitor-induced angioedema. N Engl J Med. 2015; 372:418-25.

(24.) Strassen U, Bas M, Hoffmann TK, Knopf A, Greve J. Treatment of angiotensin receptor blocker-induced angioedema: a case series. Laryngoscope. 2015; 125: 1619-23.

(25.) Bova M, Guilarte M, Sala-Cunill A, Borrelli P, Rizzelli GM, Zanichelli A. Treatment of ACEI-related angioedema with icatibant: a case series. Intern Emerg Med. 2015; 10:345-50.

(26.) Azofra J, Dfaz C, Antepara I, Jauregui I, Soriano A, Ferrer M. Positive response to omalizumab in patients with acquired idiopathic nonhistaminergic angioedema. Ann Allergy Asthma Immunol. 2015; 114:418-9.

Cita Zupanc [1,2], Mitja Kosnik [1,2] ([mail])

[1] University Clinic for Respiratory and Allergic Diseases, Golnik, Slovenia. [2] Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. ([mail]) Corresponding author: mitja.kosnik@klinika-golnik.si
Table 1 | Age and sex distribution of IAE and ACEI-AE.

                       Age (years)                Sex
                   Average [+ or -] SD            n (%)

                                           Male        Female

IAE (n = 177)      49.6 [+ or -] 17.3    62 (35.0)   115 (65.0)
ACEI-AE (n = 80)   62.9 [+ or -] 12.9    43 (53.8)   37 (46.2)
                        p < 0.01         p < 0.01

Legend: IAE = idiopathic angioedema; ACEI-AE = angiotensin-converting
enzyme inhibitor-induced angioedema

Table 2 | Comparison of IAE and ACEI associated AE location.

                            Oral cavity
                    (tongue, pharynx, larynx)

                       Yes          No/NI

IAE (n = 177)      80 (45.2%)    97 (54.8%)
ACEI-AE (n = 80)   49 (61.25%)   31 (38.75%)
P                             NS

                            Others areas
                     (lips, eyes, extremities)

                       Yes           No/NI

IAE (n = 177)      149 (84.18%)   28 (15.82%)
ACEI-AE (n = 80)   65 (81.25%)    15 (18.75%)
P                              NS

Legend: IA = idiopathic angioedema; ACEI-AE = angiotensin-converting
enzyme inhibitor-induced angioedema; NI = no information. We assumed
that, when the location of angioedema in a particular location was
not mentioned in the patient's medical file, that location was not
involved; NS = not significant

Table 3 | Comparison of the number of AE episodes anytime in the
past, episode severity (the most severe episode of each patient), and
medical treatment of the most severe episodes between the IAE group
and ACEI-AE.

                        Number of AE        Episode severity
                    episodes anytime in
                         the past

                   1-2   3-10   > 10   Mild   Moderate    Severe

IAE (n = 177)      48     62     67     57       77         43
ACEI-AE (n = 80)   30     26     24     14       36         30
P                         NS                  p < 0.001

                          Medical treatment of the most
                                 severe episode

                   None   Family doctor   Hospitalization

IAE (n = 177)       64         83               30
ACEI-AE (n = 80)    14         45               21
P                           p < 0.0015

Legend: IAE = idiopathic angioedema; ACEI-AE = angiotensin-
converting enzyme inhibitor-induced angioedema; NS = not significant
Data were obtained from medical files
COPYRIGHT 2016 Association of Slovenian Dermatovenerologists
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2016 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Zupanc, Cita; Kosnik, Mitja
Publication:Acta Dermatovenerologica Alpina, Pannonica et Adriatica
Date:Jan 1, 2016
Words:3150
Previous Article:Successful removal of hyperkeratotic-lichenoid reaction to red ink tattoo with preservation of the whole tattoo using a skin grafting knife.
Next Article:Immunohistochemical analysis of melanocyte content in different zones of vitiligo lesions using the Melan-A marker.
Topics:

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters