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Amiodarone-induced lupus. (Medical News From Around The World).

GERMANY -- A 59-year-old man with a history of infective endocarditis complained of abrupt-onset fever, pleuritic chest pain, nonproductive cough, malaise, and joint pain, according to a report in Primary Care Drug Alerts (May 2002). Two years earlier, he had been started on a regimen of 200 milligrams of amiodarone daily and an anticoagulant for atrial fibrillation. He has since experienced several episodes of unexplained myalgia, fever, malaise, arthralgias, and discrete knee joint effusions.

Physical examination showed a slightly elevated temperature and jugular venous pressure, holosystolic murmur, enlarged liver, abnormal pulse, and pleural effusions. The patient was given antibiotics for bacterial endocarditis, but all cultures were shown to be negative for infection.

Once the antibiotics and amiodarone were stopped, the pleuropericardial effusions improved. Although this was not a clear-cut case, it was thought that the patient suffered from drug-induced lupus. There has only been one other reported case of this kind.
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Publication:Nutrition Health Review
Article Type:Brief Article
Geographic Code:4EUGE
Date:Sep 22, 2002
Words:150
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