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Amino acids, peptides and proteins in organic chemistry; 5v.


Amino acids, peptides and proteins in organic chemistry; 5v.

Ed. by Andrew B. Hughes.



3600 pages




Although the publisher's website makes no mention of it, the cover copy for this five-volume set makes mention of a sixth volume, which might be forthcoming. Each volume has its focus, as follows. Volume 1, Origins and Synthesis of Amino Acids comprises two parts, on the origins of extraterrestrial and "terrestrial" amino acids and their evolution, and on production and synthesis. Volume 2, Modified Amino Acids, Organocatalysis and Enzymes, begins with synthesis and chemistry and then deals with the catalysis of reactions. Following is a section devoted to enzymes, including proteases as catalysts, peptide-based enzyme models, substrate and protein recognition and mammalian and insect peptide hormones. Volume 3, Building Blocks, Catalysis and Coupling Chemistry, deals with the generation of alpha-amino acids, beta-lactams, and heterocycles as well as the synthesis of peptides, especially solid phase synthesis but with coverage of solution phase peptide synthesis, coupling reagents, chemical ligation, peptide purification, and automation. Volume 4, Production Reactions, Medicinal Chemistry, Combinatorial Synthesis, covers protection reactions and amino acid-based peptidomimetics; the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis, among others; and methods such as phage display, library peptide synthesis, and computational design. Volume 5, Analysis and Function of Amino Acids and Peptides presents classical as well as newer. As stated on the back cover of each volume, a sixth volume (not included) is subtitled, Peptide Natural Products and Amino Acid Chemistry Development. Hughes is affiliated with La Trobe U., Melbourne, Australia.

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Publication:Reference & Research Book News
Article Type:Brief article
Date:Apr 1, 2013
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