Air pollution and congenital anomalies.
Vrijheid et al. (p. 598) systematically reviewed epidemiological studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. They found 10 relevant studies, each of which reported an association between exposure to air pollutants and congenital anomalies. Nitrogen dioxide and sulfur dioxide exposures were associated with coarctation of the aorta and tetralogy of Fallot. Exposure to particulate matter [less than or equal to] 10 [micro]m was associated with atrial septal defects. Meta-analyses found no statistically significant increase in other cardiac anomalies or oral clefts. The authors note that improvements in exposure assessment, outcome harmonization, assessment of other congenital anomalies, and mechanistic knowledge are needed.
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|Publication:||Environmental Health Perspectives|
|Article Type:||Brief article|
|Date:||May 1, 2011|
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