Acute Myeloid Leukemia with Hypothalamic Involvement Causing Central Diabetes Insipidus/Akut Miyeloid Loseminin Hipotalamus Tutulumuna Bagli Santral Diabetes Insipidus.
Anahtar Kelimeler: Akut miyeloid losemi, hipotalamus, manyetik rezonans goruntuleme, santral diabetes insipidus
A 37-year-old man presented to the emergency department with symptoms of high fever, polyuria, and polydipsia. A physical examination revealed body temperature of 37.8 [degrees]C, heart rate of 118 beats per minute, blood pressure of 95/60 mmHg, and oxygen saturation of 97% in room air. The patient had pale conjunctiva. He had no past medical history. A detailed recent history showed that the patient had unintentional weight loss of 20 pounds in the past 1 month.
Laboratory tests revealed low white blood cell count (2x[10.sup.3]/[micro]L; normal range 4-10x[10.sup.3]/[micro]L), low hemoglobin count (10.2 g/dL; normal range 14-16 g/dL), elevated C-reactive protein level (2.6 mg/dL; normal range 0-0.5 mg/dL), high erythrocyte sedimentation rate (80 mm/h; normal range 0-15 mm/h), high mean cell volume (132 fL; normal range 80-96 fL), high platelet count (603x[10.sup.3]/[micro]L; normal range 150-400x[10.sup.3]/[micro]L), and elevated serum sodium level (157 mEq/L; normal range 135-145 mEq/L). The physical examination, clinical history, and laboratory findings suggested diabetes insipidus. Hormone analysis showed decreased pituitary hormones levels (thyroid-stimulating hormone 0.04 [micro]IU/mL; normal range 0.2-4.2 [micro]IU/mL, free-T4 0.801 ng/dL; normal range 0.99-1.65 ng/dL, cortisol 3.21 ug/dL; normal range 10-20 ug/dL, adrenocorticotropin 7.3 pg/mL; normal range 8-50 pg/mL). The clinical and laboratory findings of the patient showed panhypopituitarism.
The patient underwent hyponatremic intravenous hydration (0.45% saline and 5% dextrose). After this treatment, the 24-hour urine volume was 6000-7000 cc. A water deprivation test demonstrated worsening of hypernatremia. The serum osmolality test showed hyperosmolarity with inappropriate low urine osmolality. Urinary osmolality was increased twofold following vasopressin administration. Nasal 1-deamino-8-D-arginine vasopressin was started with the diagnosis of central diabetes insipidus (CDI). Polydipsia and polyuria were improved.
The serum total protein level was decreased (52 g/L; normal range 65-85 g/L) and beta-2 microglobulin level was elevated (6.3 mg/L; normal range <2 mg/L). Serum immunoglobulin levels were normal. A smear of bone marrow aspirate showed sheets of myeloid cells that accounted for 82% of the overall nucleated cell population. Large, bi-nucleate and trinucleate forms were noted. Many of these atypical myeloid cells contained small, inconspicuous nucleoli. The patient was diagnosed as having acute myeloid leukemia (AML). Genetic analysis showed monosomy of chromosome 7.
The patient underwent contrast-enhanced cranial magnetic resonance imaging (MRI) to investigate the cause of CDI and panhypopituitarism. MRI showed hypothalamic hyperintensity on fluid attenuation inversion recovery images and contrast enhancement on T1-weighted images (Figure 1, 2).
CDI is an unusual complication of AML and is seen in less than 1% of patients with AML. The pathogenesis of CDI in patients with myeloid leukemia is unclear. It has been reported that CDI associated with AML may develop due to different mechanisms such as leukemic infiltration, chromosomal abnormalities, thrombocytosis, and dysmegakaryopoiesis. Peri pituitary leukemic infiltrations have been shown in postmortem studies in patients with AML without clinical CDI (1,2).
Informed Consent: Written informed consent was taken from patient.
Peer-review: Internally peer-reviewed.
Surgical and Medical Practices: M.S.E., M.D., Concept: M.S.E., M.D., Design: M.S.E., M.D., Data Collection or Processing: M.D., F.U., Analysis or Interpretation: F.U., Literature Search: M.D., F.U., Writing: F.U.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study has received no financial support.
(1.) Dy P, Chua P, Kelly J, Liebman S. Central diabetes insipidus in the setting of acute myelogenous leukemia. Am J Kidney Dis 2012;60:998-1001.
(2.) Yamagami K, Yoshioka K. Central diabetes insipidus presenting as an early sign of acute myeloid leukemia. Clin Adv Hematol Oncol 2012;10:400-401.
Furkan Ufuk (1), Mehmet Duran (1), Mehmet Sercan Erturk (2)
(1) Pamukkale University Faculty of Medicine, Department of Radiology, Denizli, Turkey
(2) Pamukkale University Faculty of Medicine, Department of Endocrinology, Denizli; Mus State Hospital, Department of Endocrinology, Mus, Turkey
Address for Correspondence/YaZisma Adresi: Furkan Ufuk MD, Pamukkale University Faculty of Medicine, Department of Radiology, Denizli, Turkey
Phone: +90 554 511 50 88 E-mail: email@example.com ORCID ID: orcid.org/0000-0002-8614-5387
Received/Gelis Tarihi: 14.06.2017 Accepted/Kabul Tarihi: 27.07.2017
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|Title Annotation:||Images in Clinical Neurology / Klinik Gorunum|
|Author:||Ufuk, Furkan; Duran, Mehmet; Erturk, Mehmet Sercan|
|Publication:||Turkish Journal of Neurology|
|Article Type:||Letter to the editor|
|Date:||Mar 1, 2018|
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