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Acute Cholecystitis and Acute Pancreatitis related to Hemobilia after Percutaneous Liver Biopsy.

INTRODUCTION

Hemobilia is a rare cause of gastrointestinal bleeding; however, a higher number of invasive hepatobiliary interventions and advancements in imaging technologies have increased the number of reported cases. Van Thiel et al. (1) were reported that the hemobilia incidence after performing percutaneous liver biopsy (PLB) was 0.023% among 12750 patients. In another retrospective study, the percentage of all major complications after performing PLB was 2.2% and hemobilia was responsible for 0.06% of all complications (4 of 68276 patients) (2). Abdominal pain, hematemesis, melena, and hepatitis are among the clinical findings of hemobilia. Acute cholecystitis and pancreatitis after hemobilia are quite rare. In the literature, only nine acute pancreatitis and eight acute cholecystitis cases have been reported as a complication after hemobilia (3). However, acute cholecystitis and acute pancreatitis secondary to hemobilia have been reported in only two cases (4, 5). Primary causes of performing hemobilia-related PLB are pseudoaneurysms on the needle tract and arterioportal fistulas. Treatment for hemobilia is conservative, but for patients with abnormal vital signs, angiographic arterial embolization or surgical intervention should be considered (6, 7).

CASE REPORT

Ultrasonography-guided liver biopsy (16-G Menghini needle) was performed an a 60-year-old female patient with chronic viral hepatitis. Her hemoglobin level, platelet count, and coagulation parameters before biopsy were normal. On the first entry, a 2-cm biopsy sample was obtained. The patient had no complaints and was discharged 6 hours after the procedure. Three days after biopsy, the patient was admitted to the emergency unit with complaints of pain in the right upper quadrant, hematemesis, and melena. Her physical examination revealed mild jaundice and was positive for Murphy's sign. Her vital signs were stable. Abnormal blood analysis results were obtained: hemoglobin: 10 g/dL, aspartate aminotransferase (AST): 120 IU/L, alanine aminotransferase (ALT): 100 IU/L, gama glutamyl transferase (GGT): 300 IU/L, alkaline phosphatase (ALP): 510 IU/L, total bilirubin: 5.2 g/dL, direct bilirubin: 3.5 g/dL, amylase: 530 IU/L, and lipase: 1200 IU/L. Abdominal ultrasound showed a hydropic gallbladder, thick walls (5 mm), and heterogeneous hyperechoic materials indicating a hematoma. Abdominal computed tomography (CT) revealed that the gallbladder was hydropic and that the gallbladder walls were distinctively thick; intrahepatic bile ducts, particularly the right ones, were minimally dilated, and on the inside, there were hyperechoic material (Figure 1). The morphology of the pancreas was normal. Upper endoscopy was performed, and a large blood clot was observed on the papilla. The patient was transferred to the gastroenterology department with a diagnosis of hemobilia, acalculous cholecystitis, and acute pancreatitis. Oral feeding was stopped. Intravenous fluids and proton pump inhibitors were started. After 4 days of treatment, amylase-lipase levels were normal; the patient stabilized and was discharged. Twenty-four hours later, the patient was re-admitted to the clinic because of repeated complaints of hematemesis and melena. His physical examination indicated a blood pressure of 100/60 mmHg and pulse of 100 beats/min; his hemoglobin levels dropped from 10 g/dL to 8.5 g/dL. Hepatic angiography was performed after administering parenteral fluids and 2 units of erythrocyte suspension replacement. Hepatic angiography revealed a non-bleeding, 10-mm pseudoaneurysm on the right hepatic artery (Figure 2). After superselective catheterization, the pseudoaneurysm was occluded by glue and lipidiol (Figure 3). The patient did not show any more bleeding thereafter and was discharged with full recovery. Written informed consent was obtained from the patient.

DISCUSSION

Hemobilia is defined as bleeding within the biliary system. In the past, hemobilia-related trauma was common. Today, iatrogenic injuries of the biliary tract cause 60% of hemobilia cases due to the increasing number of invasive procedures such as PLB, percutaneous biliary drainage, and radiofrequency ablations. Other causes include gallstones, inflammation, vascular malformations, and tumors. Post-PLB hemobilia is quite rare (2, 6). The literature has documented only 32 such cases. Reported causes of biopsyrelated hemobilia are arterioportal fistulas and pseudoaneurysms. Advanced age, many needle entries, and underlying cirrhosis and malignancy increase the risk of complications (7). In our patient, despite the few needle entries, the reason for hemobilia was correlated to the cirrhotic liver.

Classical clinical findings of hemobilia are upper gastrointestinal bleeding, biliary colic, and hepatitis (Quinke's triad). However, this triad is present in only 20% of patients. The gap between performing PLB and the outset of hemobilia can be within the following several hours or may extend until the 21st day. The average onset time is 5 days (3). Our patient presented to the clinic 3 days after successful PLB and showed all symptoms in Quinke's triad.

For the diagnosis of hemobilia, ultrasonography and CT are reliable and non-invasive methods. Within the biliary system, an echogenic shadow resembling gallbladder sludge is visible. Upper gastrointestinal endoscopy helps detect bleeding from the papilla, but if the bleeding is intermittent, this method may not usually useful. Endoscopic retrograde cholangiopancreatography (ERCP) is useful for locating and extracting blood clots. Angiography is preferred for the diagnosis and treatment of pseudoaneurysms, arteriobiliary fistulas, and arterioportal fistulas (5, 6).

Patients with hemobilia rarely suffer from complications such as acute cholecystitis or acute pancreatitis. By acting like a gallstone, a blood clot in the gallbladder may lead to biliary colic, obstructive jaundice, acute cholecystitis, or acute pancreatitis (8). In the literature, there are only two cases of patients with acute cholecystitis and acute pancreatitis after performing PLB. Albuqerque et al reported on a 21-year-old female patient with chronic glomerulonephritis and HCV. Although hepatic angiography was initially useful for controlling the symptoms, cholecystectomy was required after the recurrence of hemobilia (4). The second case was reported by Egritas et al. (5) after PLB was performed for the etiological analysis of hepatosplenomegaly on a 7-year-old patient; the patient received supplementary treatment. Our patient was initially treated by conservative management such as IV fluid replacement and blood transfusion; however, ongoing hemobilia required the occlusion of the pseudoaneurysm by hepatic angiography and glue and lipidiol embolization. In the follow-up, ERCP was not required as the cholestatic enzyme levels were low.

Selective hepatic angiography is a reliable method for diagnosing pseudoaneurysms. It not only directly reveals the pseudoaneurysm but also is effective for stopping the bleeding by embolization of the related vessel. If this fails, surgery intervation should be kept in the mind (9, 10).

CONCLUSION

Percutaneous liver biopsy is a reliable method for evaluating liver diseases. However, complications like hemobilia and secondary acute cholecytitis and pancreatitis have been rarely described after PBL. Hepatic angiography embolization is an effective method for managing patients who suffer from uncontrollable bleeding.

Informed Consent: Written informed consent was obtained from patient who participated in this study.

Peer-review: Externally peer-reviewed.

Author Contributions: Conceived and designed the experiments or case: BDO., GK. Performed the experiments or case: BDO., GK. Analyzed the data: BDO. Wrote the paper: BDO. All authors have read and approved the final manuscript.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.

REFERENCES

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(2.) Van Thiel DH, Gavaler JS, Wright H, Tzakis A. Liver Biopsy. Its safety and complications as seen at a liver transplant center. Transplantation 1993; 55(5):1087-90. [CrossRef]

(3.) Piccinino F, Sagnelli E, Pasquale G, Giusti G. Complications following percutaneous liver biopsy. A multicentre retrospective study on 68.276 biopsies. J Hepatol 1986; 2(2): 165-73. [CrossRef]

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(6.) Egritas O,Dalgic B, Sendur HN. Cholecystitis, pancreatitis and hemobilia: a serious trilogy after liver biopsy. Pediatr Int 2010; 52(4): e215-7. [CrossRef]

(7.) Machicao VI, Lukens FJ, Lange SM, Scolapio JS. Arterioportal fistula causing acute pancreatitis and hemobilia after liver biopsy. J Clin Gastroenterol 2002; 34(4): 481- 4. [CrossRef]

(8.) Ahmed A, Samuels SL, Keeffe EB, Cheung RC. Delayed fatal hemorrhage from pseudoaneurysm of the hepatic artery after percutaneous liver biopsy. Am J Gastroenterol 2001; 96(1): 233-7. [CrossRef]

(9.) Curet P, Baumer R, Roche A, Grellet J, Mercadier M. Hepatic hemobilia of traumatic or iatrogenic origin: recent advances in diagnosis and therapy, review of the literature from 1976 to 1981. World J Surg 1984; 8(1): 2-8. [CrossRef]

(10.) McGill DB, Rakela J, Zinsmeister AR, Ott BJ. A 21-year experience with major hemorrhage after percutaneous liver biopsy. Gastroenterology 1990; 99(5): 1396-400. [CrossRef]

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(12.) Kowdley KV, Aggarwal AM, Sachs PB. Delayed hemorrhage after percutaneous liver biopsy. Role of therapeutic angiography. J Clin Gastroenterol 1994; 19(1): 50-3. [CrossRef]

(13.) Van Os EC, Petersen BT. Pancreatitis secondary to percutaneous liver biopsy-associated hemobilia. Am J Gastroenterol 1996; 91(3): 577-80.

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Banu Demet Ozel coskun (1), Gulten Can Sezgin (2), Guven Kahraman (3)

(1) Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey

(2) Department of Gastroenterology, Erciyes University Faculty of Medicine, Kayseri, Turkey

(3) Department of Radiology, Erciyes University Faculty of Medicine, Kayseri, Turkey

Submitted 01.11.2016

Accepted 20.07.2017

Available Online Date 31.10.2017

Correspondence Banu Demet Ozel coskun, Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey Phone: +90 352 336 88 84 e.mail: demetcoskun2@gmail.com

DOI: 10.5152/etd.2017.16114

Cite this article as: Ozel Coskun BD, Can Sezgin G, Kahraman G. Acute Cholecystitis and Acute Pancreatitis associated with Hemobilia after Performing Percutaneous Liver Biopsy. Erciyes Med J 2017; 39(4): 189-91.
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Title Annotation:CASE REPORT
Author:coskun, Banu Demet Ozel; Sezgin, Gulten Can; Kahraman, Guven
Publication:Erciyes Medical Journal
Date:Dec 1, 2017
Words:1696
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