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Acrolein and neuro disorders.

Neurologic disorders are among the leading causes of death and illness in the United States. Their causes are poorly understood, but one of the emerging suspected culprits is the substance acrolein, which tends to be significantly elevated in the brains or spinal cords of people who have Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis (ALS), and other neurologic disorders. (1-4) A new study adds multiple sclerosis (MS) to the list of disorders potentially affectedA by this substance. (5)

Acrolein is produced naturally in the body as a by-product of membrane lipid peroxidation. It also occurs in combustion by-products such as vehicle exhaust, industrial emissions, oil- and coal-fired power plant emissions, cooking fumes, and the smoke from burning cigarettes, wood, and plastics. It's used as a biocide and to manufacture other chemicals and products such as chemical weapons. The U.S. Environmental Protection Agency (EPA) has determined the ubiquitous pollutant is a major source of respiratory damage. (6) But information on the neurologic effects of environmental acrolein is scant.

In the new study, Riyi Shi of Purdue University and colleagues injected mice with substances known to induce experimental autoimmune encephalomyelitis, an animal model for MS. (5) Within 2 weeks acrolein--lysine adduct levels in the spinal cord began to rise, peaking at 65% higher than in controls at about day 20. At the same time, the mice began to display significant muscle control problems. Treatment with the acrolein-scavenging substance hydralazine reduced those effects to a great although not significant degree. The researchers also detected significant mitigation of damage to the myelin sheath by hydralazine.

Shi and colleagues say their study provides the first evidence that endogenous acrolein plays a key role in MS. Shi says it's plausible that environmental acrolein can act in the same genera) way: "There's no reason not to believe that the same type of damage could occur."

Richard LoPachin, a neurochemist and director of research at Montefiore Medical Center in New York, partially agrees. "Because acrolein is highly reactive with proteins at the site of exposure, it has limited distribution in the body and, therefore, limited access to the brain," he says. But acrolein is just one of many type-2 alkenes, a large family of environmental and food contaminants that includes acrylamide, methyl vinyl ketone, methyl acrylate, and 4-hydroxynonenal. LoPachin says type-2 alkenes share a common mechanism of action at nerve terminals in the brain, and he thinks the combined effects of these substances could contribute to some neurologic disorders.

Robert Kavlock, director of the EPA National Center for Computational Toxicology, says acrolein's physical properties make it difficult to assess the compound using the agency's ToxCast[TM] high-throughput chemical screening program using currently available technology. (7) But pinning down the causes of these neurologic disorders could help millions of people. In the United States alone, about 5.3 million people have Alzheimer disease, (8) about 1.5 million have Parkinson disease, (9) about 400,000 have MS, (10) and about 30,000 have ALS. (11)

REFERENCES AND NOTES

(1.) Singh M, et al. Role of by-products of lipid oxidation in Alzheimer's disease brain; a focus on acrolein. J Alzheimers Dis 2t(3):741-756 (2010); doi:l0.3233/JAD-2010-100405.

(2.) Tanuma N, et al. Oxidative stress as a biomarker of respiratory disturbance in patients with severe motor and intellectual disabilities. Brain Dev 30(61402-409 (2008); doi: 10.1016/j.bramdev.2007.12.001

(3.) Jomova K, et al. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 345(1-2): 91-104(2010); doi:10.1007/s11010-010-0563-x.

(4.) LoPachin RM, et al, Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases. Neurotoxicol 29(5):871-882 (2008), doi:10.1016/j.neuro.2008 04.016.

(5.) Leung G, et al Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse Neurosdence 173:150-155 (2011): doi:10.1016/j.neurosdence.2010.11.018.

(6.) EPA. Summary of Results for the 2002 National-Scale (Air Toxics) Assessment; National Noncaricer Hazard Drivers [website]. Washington, DC:U.S. Environmental Protection Agency (updated 3 Aug 2010). Available: http://tinyurl.com/lk59lq [accessed 6 Jan 2011].

(7.) Other officials from the EPA and the U.S. Agency for Toxic Substances and Disease Registry declined to discuss type-2 alkenes in relation to neurologic disorders

(8.) Alzheimer's Association. 2010 Alzheimer's Disease Facts and Figures. Chicago. IL: Alzheimer's Association (2010).

(9.) Venes D, ed. Taber's Cyclopedic Medical Dictionary, 21st Edition. Philadelphia, PA:F.A. Davis Co. (2009).

(10.) Who Gets MS? [website]. Cherry Hill, NJ:Multiple Sclerosis Association of America (updated 25 Aug 2010). Available: http://tinyurl.com/2g4t884 [accessed 6 Jan 2011].

(11.) Who Gets ALS? [website]. Washington, DC:The AL5 Association (updated Sep 2007). Available: http://tinyurl.com/2bmsfdc [accessed 6 Jan 2011].

Bob Weinhold, MA, has covered environmental health issues for numerous outlets since 1996. He is a member of the Society of Environmental Journalists.
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Title Annotation:NEUROLOGIC HEALTH
Author:Weinhold, Bob
Publication:Environmental Health Perspectives
Article Type:Report
Geographic Code:1USA
Date:Feb 1, 2011
Words:808
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