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Acne in South African black adults: A retrospective study in the private sector.

Acne vulgaris is a disorder of the pilosebaceous unit that affects areas with a high density of sebaceous glands, i.e. the face, chest and back. It is a multifactorial disorder induced by hormonal changes, excessive sebum production, fluctuation of resident micro-organisms and accumulation of dead skin cells in hair follicles. [1-3] This dysregulation results in the non-inflammatory lesions (comedones), inflammatory lesions (papules and pustules) and acne conglobate (nodules and cysts) seen in acne.

Acne is the most common skin disorder diagnosed by dermatologists and other healthcare providers worldwide, and mostly affects adolescents. [4-8] The worldwide prevalence is ~9.4%. In adolescents, the prevalence is 65-75%. [1, 2] In Durban, South Africa (SA), with a population of 2.901 million,'91 it has been documented as the second most common skin disease, with females mainly affected (1.75:1). [10, 11] Although acne has traditionally been thought to be a disorder of teenagers and adolescents, children and adults have been noted to be increasingly affected. [3-5, 12, 13]

Scarring and post-inflammatory hyperpigmentation (PIH) are the main sequelae of acne. The effects of PIH have mainly been documented in black patients, as PIH is most common in dark-skinned individuals. Many patients seek therapy for PIH even after the active lesions have resolved. [7, 8, 14, 15]

Widespread use of antibiotics has raised concerns regarding resistance in Propionibacterium acnes and other host commensals. [10] Oral antibiotics should only be used at the beginning of treatment, for as short a time as possible, in combination with a non-antibiotic topical agent. Many patients experience flare-ups after cessation of successful therapy, making maintenance therapy necessary even during remission. [11, 12] Appropriate skin care should be integrated into the management of acne to help minimise recurrence. [12] This underlines the importance of early diagnosis to prevent complications and reduce the financial and psychological costs, which can be significant. The cost of acne therapy has been calculated as up to USD350-870 per patient per year in the USA. [2] No comparable data on acne costs are available for SA.

The presence of acne, particularly in adolescents, can negatively affect quality of life, self-esteem and mood. Suicidal ideation has been documented in ~7.1% of affected individuals. [4] This further illustrates the importance of early and aggressive treatment.

There are no studies specifically describing acne in black patients in the private health sector in SA.

Objective

To describe acne in black adults in Durban, KwaZulu-Natal Province, SA.

Methods

This was a retrospective review of records of black patients attending two private dermatology clinics in Durban over a 12-month period (January-December 2014, inclusive). The two clinics serve the majority of black patients seeking private dermatological treatment in Durban (~8 000 patients per annum).

Inclusion criteria were: (i) a diagnosis of acne; and (ii) black African patients. Exclusion criteria were: (i) ethnic groups other than black African; (ii) age < 18 years; and (iii) non-South African patients. Age, gender, spectrum and severity of disease, therapeutic modalities, HIV status and treatment outcomes were analysed.

Statistical analysis

Sample size was calculated using Stata 14 (StataCorp, USA). Data analysis was performed by the Division of Biostatistics, South African Medical Research Council, and results were presented as frequencies and percentages for discrete data and means with standard deviations (SDs) for continuous data.

Ethical approval

Ethical approval was obtained from the University of KwaZulu-Natal Biomedical Research Institutional Review Board (ref. no. BE 283/15).

Results

Of the charts reviewed over the 12-month period, 242 fulfilled the inclusion criteria and were therefore retrieved for analysis (Table 1).

There were more females in the study cohort (84.3%) than males (15.7%). Nearly two-thirds of the patients had a tertiary education. The majority of the patients (93.4%) received topical plus systemic treatment, with 97.5% showing improvement. Of the cohort, 6.6% were HIV-positive.

Fig. 1 shows the breakdown of the types of acne seen in the study (inflammatory, non-inflammatory, steroid-induced and other types). Inflammatory acne was the commonest type in this patient cohort (58.6%), followed by non-inflammatory acne (23.6%) and steroid-induced acne (8.6%). Other types of acne were seen in 9.5% of patients.

Fig. 2 shows the severity of acne in the patient cohort, categorised by the clinician as mild, moderate, severe and unspecified at the time of diagnosis. Most of the patients (73.1%) had moderate acne at time of diagnosis, 13.6% had mild acne and 10.8% had severe acne.

Fig. 3 displays the sequelae of acne in the patient cohort, i.e. PIH and other (keloids and scarring). Over 80% of patients had PIH. Just over 2% had other sequelae such as scarring and keloids.

Discussion

This study of black patients with acne in Durban documents characteristics of the most common skin disorder in the largest population group in SA. The mean age of the patients was 28.5 years. Studies have shown acne mainly to affect teenagers and young adults (65-75%), sometimes persisting into the 30s. [2, 11-15] The prevalence is highest in the age group 16-19 years, with ~20% of cases persisting beyond the age of 20. [5]

Social development and considerable self-image awareness during adolescence means that acne can cause cosmetic concerns in this age group that may lead to significantly low self-esteem. However, our study shows that acne also affects adults into middle age, as has been documented by others. [1, 7, 8] Females mainly appeared to be affected, with a female/male ratio of ~5:1, although this could be because females are more likely than males to consult a dermatologist for a skin condition. Other studies have documented a female/male ratio of ~2:1. [16]

A significant proportion of the patients in our study (52.5%) were self-referred. This may be linked to the relatively high level of education of the study cohort, 56.2% of whom had a tertiary or postgraduate qualification, which indirectly translates to being able to afford to see a private dermatologist. The high number of self-referrals could also be a result of failure of a primary healthcare provider to control the acne.

HIV infection has been documented in patients with acne. [5,17] In our cohort 6.6% patients (n=16) were documented to be HIV-positive. Four of these patients (25.0%) had nodulocystic acne, which has previously been reported in HIV-positive individuals but can also be seen in those who are HIV-negative. [15]

Inflammatory acne was the most frequently observed type in our cohort, as has been documented in several other studies. [6, 13-16, 18] The significant proportion of our patients with steroid-induced acne (8.3%) may be due to the widespread abuse of skin-lightening agents containing cortisone, [19] to which individuals living in Durban have easy access in the marketplace. In a 2006 Nigerian study, [8] 45.3% of patients had steroid-induced acne following cosmetic use of topical corticosteroids. Other studies have reported prevalences of up to 45%. [3, 20, 21] These cases were associated with both topical corticosteroid abuse for skin lightening in black patients, and anabolic steroids used by body builders.

Most of the patients in this study had moderate disease (73.1%) and almost all patients improved with the use of either topical or topical plus systemic treatment. The majority of the patients (93.4%) received systemic treatment in combination with topical treatment. One patient (0.4%) was reported not to have not improved, and 5 patients (2.1%) defaulted from follow-up and their outcome could therefore not be recorded. As has been demonstrated in many previous studies, [13, 14, 16, 21] our patients suffered significant sequelae once their acne had resolved. PIH was a frequent finding (81.0%), as in previous studies that have shown prevalences of PIH of 65-75% in black patients. [13-16, 18] In a study by Perkins et al., [1] African American patients were found to have a higher prevalence of dyspigmentation and scarring than their white counterparts. This finding has also been reported by others. [17, 22-26] PIH has been rated as the most troublesome sequela experienced by black patients following inflammatory acne, in contrast to white patients, among whom scarring is more common. [7, 23, 27-29]

Study limitations

Although the findings of the current study outline the characteristics of acne in black patients, it has certain limitations. These include the use of patient records from only two private sector health facilities, which may not be representative of the entire Durban region. Also, patients aged <18 years were excluded from the study. A comparison between various ethnic groups would also have been useful. Finally, the study was retrospective and the findings may need to be validated by a prospective study in the future.

Conclusion

This study of black patients in Durban, SA, shows that acne mainly affects young females. This finding may be due to females being more likely to seek medical attention for this cosmetically disturbing disorder. In terms of severity, the majority of patients had mild or moderate acne, with inflammatory acne being the most common subtype. The most significant sequela is PIH, with > 80% of patients affected.

Early recognition of acne and prompt and aggressive therapy are important, and may minimise complications and reduce the cost of treatment.

Acknowledgements. Author TPZ sincerely thanks Prof. N C Dlova for giving her permission to access and use her patient data records, Dr T Mabaso for allowing her to use his premises, and Miss Mpume Luthuli and Miss Xoliswa Ngubeni for assisting with retrieval of data. Author contributions. All the authors participated in data collection, data analysis and interpretation, drafting the article, revision of the article and final version of the article to be published. Funding. None. Conflicts of interest. None.

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Accepted 29 June 2017.

T P Zulu, BSc, MB ChB, FC Derm (SA), MMed; A Mosam, MB ChB, FC Derm (SA), MMed, PhD; Y Balakrishna, MSc (Statistics); N C Dlova, MB ChB, FC Derm (SA), PhD

Department of Dermatology, School of Clinical Medicine, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

Corresponding author: TP Zulu (tpzulu@gmail.com)
Table 1. Demographic characteristics of patients with acne (N=242),
source of referral, HIV status, therapy and outcome

Characteristic

Gender, n (%)
  Male                          38 (15.7)
  Female                        204 (84.3)
Source of referral, n (%)
  General practitioner          115 (47.5)
  Self                          127 (52.5)
Highest qualification, n (%)
  Primary                       9 (3.7)
  Secondary                     55 (22.7)
  Tertiary                      128 (52.9)
  Postgraduate                  8 (3.3)
  Unspecified                   42 (17.4)
HIV status, n (%)
  Positive                      16 (6.6)
  Negative                      19 (7.9)
  Unknown                       207 (85.5)
Treatment, n (%)
  Topical                       15 (6.2)
  Topical plus systemic         226 (93.4)
  Other                         1 (0.4)
Outcome, n (%)
  Improvement                   236 (97.5)
  No improvement                1 (0.4)
  Defaulted                     5 (2.1)
Age (yr), mean (range)          28.5 (18-59)

Fig. 1. Spectrum of acne according to clinical type in black
patients attending two private dermatology clinics.

                    Type of acne

Inflammatry            58.6
Non-inflammatory       23.6
Other                   9.5
Steriod induced         8.3

Note: Table made from bar graph.

Fig. 2. Severity of acne in black patients attending two private
dermatology clinics.

               Severity of acne

Mild                13.6
Moderate            73.1
Severe              10.8
Unspecified          2.5

Note: Table made from bar graph.

Fig. 3. Complications of acne in black patients attending two
private dermatology clinics. (PIH = post-inflammatory
hyperpigmentation.)

PIH     81.0%
Other    2.1%
None    16.9%

Note: Table made from pie chart.
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Article Details
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Title Annotation:RESEARCH
Author:Zulu, T.P.; Mosam, A.; Balakrishna, Y.; Dlova, N.C.
Publication:South African Medical Journal
Article Type:Report
Geographic Code:6SOUT
Date:Dec 1, 2017
Words:2768
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