Printer Friendly

Aclaris Therapeutics Acquires Confluence Life Sciences in USD 100m Deal.

M2 EQUITYBITES-August 11, 2017-Aclaris Therapeutics Acquires Confluence Life Sciences in USD 100m Deal


11 August 2017 - US-based drugmaker Aclaris Therapeutics, Inc. (NASDAQ: ACRS) has acquired US-based biotechnology firm Confluence Life Sciences, Inc., the company said.

Confluence Life Sciences is a privately held firm focused on the discovery and development of kinase inhibitors to treat inflammatory and immunological disorders and cancer.

At the closing, Aclaris paid approximately USD 10m in cash and issued approximately 350,000 shares of its common stock, with a value of approximately USD 10m on the closing date, to the former equityholders of Confluence.

Confluence also stand to receive around USD 80m following the close of the deal, in royalty payments and payments for achieving certain milestones.

This strategic acquisition expands Aclaris' inflammation and immunology pipeline with the addition of Confluence's lead product candidates: CDD-450, a novel MK-2 pathway inhibitor, topical Janus kinase inhibitors, and IL2-inducible T-cell kinase inhibitor programmes.

JAK inhibitors may be useful for treating inflammatory and autoimmune disorders such as alopecia areata, vitiligo, atopic dermatitis and others.

ITK inhibitors are non-receptor tyrosine kinase inhibitors of the activity of IL2-inducible T-cell kinase, thereby interfering with the development and effector function of immune system T-cells. ITK is a key signaling component of all T-cell receptors and is also key for regulating IL-17 expression.

The combination of inhibiting TCRs (inhibiting T-cell maturation and activation) as well as IL-17 means an ITK inhibitor can be thought of as a "small molecule anti-IL-17," but with broader immunomodulatory activity.

ITK inhibitors have potential therapeutic applications in autoimmune and inflammatory diseases such as psoriasis and atopic dermatitis.

Aclaris plans to retain all current talent and will continue to support its existing drug development plans with expected revenue from the contract research business.

Aclaris Therapeutics is a dermatologist-led biopharmaceutical company focused on identifying, developing and commercialising innovative and differentiated therapies to address significant unmet needs in medical and aesthetic dermatology.

The company is focused on large, underserved market segments with no FDA-approved medications or where treatment gaps exist. Aclaris is based in Malvern, Pennsylvania.

((Comments on this story may be sent to

COPYRIGHT 2017 Normans Media Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2017 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:M2 EquityBites (EQB)
Date:Aug 11, 2017
Previous Article:Carvana Acquires US Auto Marketplace Carlypso.
Next Article:Ultra Lithium Acquires Three More Lithium Brine Properties in Catamarca, Argentina.

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |