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Aastrom Biosciences, Loyola University perform first ever transplants of ex vivo produced stem cells in cancer patients.

Aastrom Biosciences, Inc., Ann Arbor, MI, and Loyola University Medical Center, Maywood, IL, announced they have performed the first ever-successful transplants of ex vivo-produced human stem cells in breast cancer patients. Aastrom says the human stem cells for transplantation used in the Phase II clinical trial were produced using the AastromReplicell Cell Production System and SC-1 Therapy Kit.

The study included 19 patients with Stage II-IV (12 of whom had Stage II/IIIa) breast cancer who have undergone ablative chemotherapy to treat their cancer. Aastrom and Loyola said patients received transplants of stem cells produced from a small volume of autologous bone marrow in the AastromReplicell System using the SC-1 Therapy Kit. The study was intended to evaluate whether stem cells produced ex vivo could be used by themselves to restore blood and immune system function following aggressive chemotherapy and evaluated the time to engraftment of the patients' key infection fighting white blood cells and blood-clotting cells to control bleeding.

Aastrom has developed two therapy kits, the SC-1 Therapy Kit for the production of bone marrow-derived stem cells and the CB-1 Kit for the production of cord blood cells. The company has initiated a Phase III-pivotal clinical trial evaluating the SC-1 Therapy Kit in breast cancer patients and plans to initiate a Phase III-pivotal trial of the CB-1 Therapy Kit.

Contact: Todd Simpson - (734) 930-5777
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Comment:Aastrom Biosciences, Loyola University perform first ever transplants of ex vivo produced stem cells in cancer patients.
Publication:Transplant News
Article Type:Brief Article
Geographic Code:1USA
Date:Mar 27, 2000
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