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AIST and PharmaDesign Discovers a Prediction Method for Protein Disorder Area.

Tokyo, Japan, Aug 14, 2006 - (JCN) - Advanced Industrial Science & Technology in collaboration with PharmaDesign Inc. have succeeded in finding a prediction method for Protein Disorder areas. Through this technique, improved efficiency of various experiments starting with conformation analysis of proteins and X ray crystallography and NMR will be possible.

Having a conformation structure, Proteins function by interacting with other molecules based on its unique structure. The number of conformation analysis of proteins reached 30,000 up till now, and have consumed enormous energy and time. Recent study shows that disorder areas (areas where there is no specific conformation) are seen in transcription controlled proteins and proteins with DNA.

In addition, the disorder area is not prone to crystallization and spectral assignment, therefore, analysis is easily done. PharmaDesign plans on using this prediction method for new drug discovery for its peptide library.

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Publication:JCNN News Summaries
Date:Aug 14, 2006
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