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AIST Develops Multistage-Collision Microreactor.

Tokyo, Japan, Feb 21, 2006 - (JCN) - The National Institute of Advanced Industrial Science and Technology (AIST) and Osaka Organic Chemical Industry Ltd. have jointly developed a multistage-collision type microreactor which can effectively produce intermediates of curative medicines.

This microreactor has many micro-channels of 200 mm in width and depth, in which reaction solutions can undergo multistage collisions with one another. Thus, the microreactor enables the reaction solutions to be sufficiently mixed and to complete chemical reactions. Moreover, the microreactor enables reactions which had only been below -70 C to be at -30 C, thereby reducing the cooling cost and the environmental load.

In fact, using isobutyl aluminum hydride, we have succeeded in the rapid, highly selective, low environmental load production of various kinds of aldehydes as intermediate materials for curative medicines from various kinds of esters.

This technique uses a flow-system for chemical reactions, instead of reaction vessels (flasks), and this new tool is expected to greatly cut the lead-time from research and development to production in the synthesis of curative intermediates and materials for electronics, which need a fine control of chemical reactions.

Details of this work were presented at "The Fourth International Workshop on Micro Chemical Plants" held at Kyoto from January 26 to 27, 2006.

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Publication:JCNN News Summaries
Date:Feb 23, 2006
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