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AIST, University of Tsukuba Jointly Discover New Protein Quality Control Mechanism.

Tokyo, Japan, Dec 1, 2005 - (JCN) - The National Institute of Advanced Industrial Science and Technology (AIST) announced on November 30 that its Research Center for Glycoscience has discovered a quality control mechanism of biosynthetic protein in the cell, in collaboration with the University of Tsukuba.

Specifically, the joint research group generated abnormal proteins in the GPI anchor, a group of proteins with glycolipid found in the cell. Then, they identified an elimination mechanism in which proteasome, a protease complex, degrades and eliminates abnormal proteins. This is the third protein quality control mechanism that has been discovered.

Since the GPI anchor is a protein related to several diseases including BSE and hypophosphatasia, this achievement is expected to elucidate the mechanisms of developing those diseases, promoting the development of various drugs including antfungal, antimalarial and antiprotozoal agents.

Details of the research are available in the November 30 online version of US magazine Molecular Biology of the Cell.

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Publication:JCNN News Summaries
Date:Dec 2, 2005
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