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AEterna's Neovastat shows ability to increase the angiostatin level in mice with implanted human brain cancer cells.

Data on this additional mechanism of action presented at ASCO meeting in

San Francisco

SAN FRANCISCO, California, May 14 /PRNewswire/

- Today, AEterna Laboratories Inc. (NASDAQ: AELA, TSE: AEL) presented new data showing that Neovastat/AE-941 is able to increase the level of angiostatin in mice with implanted human glioblastoma, a form of brain cancer. Results on this additional mechanism of action of Neovastat were presented in San Francisco at the American Society of Clinical Oncology (ASCO) Annual Meeting on "New Drugs in Cancer Therapy" by Professor Francois Berger, MD, PhD, neuro-oncologist and investigator of this study at the Institut national de la sante et de la recherche medicale (INSERM), in Grenoble, France.

The study consisted in injecting human glioblastoma cells (cancer cells) into the brain of nude mice. The mice were then given Neovastat in order to test its antitumoral activity. Not only did results show an antitumoral activity in Neovastat, but it also uncovered a new element of its activity which increases tissue type Plasminogen activator (tPA), an enzyme involved in the production of angiostatin. This increased tPA activity resulted in an increase in endogenous (produced by the body) angiostatin at the tumor site.

"These results are significant since this model is very aggressive and few agents are capable of improving survival time," declared Dr. Berger. "Neovastat's activation of tPA translates into a multifunctional impact including inhibition of angiogenesis and tumor infiltration. These two effects might have an important contribution in improving survival in this model."

"Glioblastomas are one of the most vascularized tumor and are VEGF- dependent. The use of an antiangiogenic agent containing several mechanisms of action, such as Neovastat, may prove effective in increasing survival time in glioblastoma patients," added Dr. Berger.

"Neovastat does not contain angiostatin, but rather agents which induce the production of endogenous angiostatin at the tumor site," said Dr. Pierre Falardeau, AEterna's Vice President of Scientific Affairs. "This particular mechanism of action further strengthens Neovastat's position as a unique angiogenesis inhibitor with multiple mechanisms of action since it has been previously shown to block the VEGF (Vascular Endothelial Growth Factor) signaling pathway, selectively inhibit matrix metalloproteinases (MMPs 2, 9 and 12) and induce endothelial cell apoptosis (programmed cell death). Therefore, instead of blocking only one of the multistep process of angiogenesis, Neovastat's several mechanisms of action could act together in a synergistic fashion to induce a more complete inhibition of angiogenesis," concluded Dr. Falardeau.


AEterna Laboratories Inc. is a Canadian biopharmaceutical company and a frontrunner in the field of antiangiogenesis. Its lead product, Neovastat/AE- 941, is being investigated in three major therapeutic areas: oncology, dermatology and ophthalmology.

Neovastat is a novel antiangiogenic product with multiple mechanisms of action that block angiogenesis - the process involved in the formation of new blood vessels which are needed in order for cancer tumors and other pathological conditions to develop.

Neovastat is currently used in two Phase III pivotal clinical trials for the treatment of lung and kidney cancer as well as in a Phase II pivotal trial for the treatment of multiple myeloma, a form of blood cancer. These trials are currently held in more than 125 clinical institutions in Canada, the U.S. and in several European countries. For more information, please call 1-888-349- 3232 (North America).

AEterna is listed on the Toronto Stock Exchange under the symbol AEL and on Nasdaq under the symbol AELA.

AEterna's news releases and additional information are available on its Web site at


This press release contains forward-looking statements, which are made pursuant to the safe harbor provisions of the U.S. Securities Litigation Reform Act of 1995. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company's actual results to differ materially from those in the forward-looking statements. Such risks and uncertainties include, among others, the availability of funds and resources to pursue R&D projects, the successful and timely completion of clinical studies, the ability of the Company to take advantage of the business opportunities in the pharmaceutical industry, uncertainties related to the regulatory process and general changes in economic conditions. Investors should consult the Company's ongoing quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned not to rely on these forward-looking statements. The Company does not undertake to update these forward-looking statements.
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Publication:PR Newswire
Date:May 14, 2001
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