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ABI Prism[R] 7900HT Sequence Detection System.

Applied Biosystems have introduced the ABI Prism [R] 7900HT Sequence Detection System. This real-time PCR instrument has been launched to speed customers' drug discovery process. The 7900HT performs gene expression quantification and detection of single nucleotide polymorphisms (SNP's) at high throughputs by taking a higher plate-density than previous generation instruments, without compromising speed, resolution or reducibility.

Identifying promising targets is the first step in developing new compounds, traditionally a slow, tedious, and expensive process. The 7900HT Sequence Detector offers a choice of assay chemistries to speed this up. The sensitive probe-based, fluorogenic 5' nuclease assay allows multiplex reactions for real-time quantification and SNP genotyping, and the Sybr[R] Breen 1 double-stranded DNA-binding dye assay is ideal for target identification in screening assays. Laser light is distributed to each well in the reaction plate, exciting the fluorescent dyes present. The fluorescent light generated is then directed through a spectrograph to a charge-coupled device (CCD) camera, giving spectrally resolved fluoresence data from each sample.

An exciting feature of the 7900HT is the automation accessory that loads up to eighty-four 384-well plated, for 24-hour hands-free operation and optimal throughput. The system also takes both 96- and 384-well plates for enhanced flexibility.

Cost-effective, high throughput gene expression studies are possible, as the sequence detector performs both absolute and relative quantification of target in unknown samples, and quantifies both target and endogenous control in multiplex reactions.
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Title Annotation:Applied Biosystems
Publication:Food Trade Review
Article Type:Brief Article
Geographic Code:1USA
Date:Feb 1, 2001
Words:231
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