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A study of split thickness skin graft technique in stable acral vitiligo.

INTRODUCTION

Vitiligo is a common acquired disorder of pigmentation that affects about 1% of the world population and spares almost no racial or ethnic groups. (1,2) It is resistant to conventional medical therapy in non-hairy areas of human body leading to great cosmetic disfigurement. (3) This situation warrants surgical manoeuvre. There are many surgical procedures, among those split thickness skin grafting is a tissue grafting procedure which provides good, cosmetically acceptable results and not time consuming, cost effective procedure. (4) Our present study deals with acral vitiligo, where the disease is very distressing.

AIMS AND OBJECTIVES

To evaluate the cosmetic results obtained with split thickness skin graft technique followed by PUVA sol therapy in stable acral vitiligo.

MATERIALS AND METHODS

The study was conducted in the Department of Dermatology, Alluri Sitaramaraju Academy of Medical Sciences Hospital and College, Eluru, during the period from November 1st 2013 to October 31st 2015. Study group includes patients with acral vitiligo for more than 1 year and resistant to medical therapy. Total eighteen patients between 19-50 yrs. of age were included. Poor immune status of patient, chronic medical illness, bleeding diathesis, infection at the site, age below 12 years were excluded. In all these patients a complete history was taken including details of age at onset, duration of vitiligo, course of disease (Stable/progressive), associated conditions like thyroid disorders, diabetes mellitus, alopecia areata, perniciousanaemia, Addison's disease. Details of any previous treatment were noted. Our study--longitudinal interventional study.

Criteria for Case Selection Inclusion Criteria

* Patches should be stationary for at least 1 year.

* No new lesions since one year.

* Koebner's phenomenon should be absent.

Exclusion Criteria

* Bleeding diathesis.

* Infection at the site.

* Age below 12 years.

* Patients with HIV/HBsAg positivity.

* Keloidal tendency.

Preoperative Evaluation and Counselling

Relevant investigations were done in all these patients like haemogram, fasting blood sugar, serum creatinine, serum TSH and urine examination for sugar, albumin, microscopy, HIV and HBsAg. In each case, the nature of the treatment was explained including benefits and side effects. Prior consent was taken.

Preparation

Both donor and recipient sites were cleaned, draped and infiltrated with local anaesthesia.

Instruments Required

Motor/manual dermabrader.

Straight artery forceps.

Sterilized razor blade.

Sterilized slides.

Tissue adhesive cyanoacrylate.

Tegaderm dressing.

PROCEDURE

Donor Site

A thin even split thin graft is obtained by razor blade held with straight artery forceps and transferred on to a slide, the graft taken should be 5 mm larger than the recipient site to avoid peripigmentary hollow.

Recipient Site

Recipient site is dermabraded with diamond burr attached to motor, till pinpoint bleeding points are seen. Then the graft placed on the dermabraded area. All patients were kept on oral antibiotics.

Followup

All patients were subjected to photochemotherapy from day 7 for a period of 3 months. Regular photographs were taken on every visit.

RESULTS

In present study out of (18) patients, (7) were male and (11) were female. Out of all cases females show significant clinical response as seen in Table 1. All females were cosmetically conscious age group and their compliance and adherence to treatment schedule leads to significant response. Young adults of age between 20-40 years comprise majority of cases and same group also exhibits more than (75%) repigmentation.

The outcome of the surgery was evaluated in terms of percentage of area of repigmentation as seen in Table 2.

Overall clinical response was excellent among 82% patients as shown in Table 2.

Overall after split thickness skin grafting, lip responded better than hand and feet as shown in Table 3, probably it is due to good vascularity on the lip area, facilitate complete acceptance of graft and drug reaches adequate proportions in graft leading to significant clinical response.

Out of 18 patients with split thickness skin grafting, 2 (11%) patients showed hyperpigmentation and 1 (6%) showed hypertrophy.

Graft failure was seen in 1(6%) patient with split thickness skin grafting.

Clinical Photographs and Outcome of Surgery Patient 1

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DISCUSSION

Vitiligo that is stabledefined as no progression of lesions already present, no fresh lesions and no evidence of Koebner phenomenon over at least 1 year. (5) It is present on non-hairy areas, does not respond to medical lines of treatment, can be managed by surgical modalities only. Surgical modalities broadly classified into tissue grafts and cellular grafts. Tissue grafts carry dermis and subcutaneous fat in addition to epidermis. The differentiation and development of the epidermal cells is regulated by the dermis. As far as tissue grafting procedures are concerned, there is a wide choice in the form of miniature punch grafting, suction blister grafting, split-thickness skin grafting and even follicular skin grafting. (6) Each of these surgical techniques has its own advantages as well as disadvantages. In surgical technique like split thickness skin grafting, wherein a thin sheet of epidermis and part of papillary dermis is taken from an appropriate donor area and then transplanted on the dermabraded vitiligo lesion. This surgical treatment offers certain advantages over other tissue grafting procedures like mini punch grafting and suction blister grafting. (7)

The cosmetic outcome achieved after split thickness skin grafting at the recipient as well as the donor site depend mostly on the quality of grafts taken. (8) With ultrathin grafts having no accompanying dermal tissue, the quality of pigmentation achieved at the recipient site is usually excellent. (9,10)

Most of the patients in our study were between 20-30 years of age, which is the most productive age group, wherein the cosmetic disfigurement of vitiligo lesions play a major role. In this study, the most favourable response was also noticed in this age group. In present study, out of (18) patients (7) were male and (11) patients were female. As a level of awareness of cosmetic disfigurement, among females it is much higher. This study showed that it is true.

It was noticed that patient of the young age group, especially females who underwent treatment for patches on the exposed parts of the body responded better than others. Lesions on the lip which was treated showed good response in (94%) of cases. Similarly, other exposed parts of the body that is hands, which were treated with split thickness skin grafting showed response in (84%) of cases. These two areas which were grafted more frequently in the young age group patients showed better response than in other age group patients. Lesions on feet showed response in (79%) cases, this was much lower than the first two areas mentioned above.

These were patients who responded better with treatment due to better compliance and regular followup.

Grafting procedures are supplemented with photochemotherapy to increase the chances of repigmentation as well as to achieve quicker results. PUVAsol is thought to have a proliferative as well as a stimulatory effect on the melanocytes donated through the grafting procedure. (11,12) Thus one can achieve a rapid repigmentation when it is used as a supplementary therapy along with grafting procedure.Clinical studies have shown that in case of split thickness skin grafting, supplemental NBUVB not only causes a rapid repigmentation, but also minimizes the chances of perigraft depigmentation. (13)

In our study, 15 (82%) out of 18 patients developed >75% pigmentation with split thickness skin grafting. Over a period from November 1st 2013 to October 31st 2015.

Khandpur et al. study, 25 (83.3%) out of 32 cases developed >75% pigmentation with split thickness grafting. Duration of study is over a period of one year. But this study is not specific for acral vitiligo;(18) cases were females and (14) cases were males; (2) cases showing hypertrophy and (1) case showed hyperpigmentation.

Imbran Majid et al. of study 20 (90%) out of 22 cases developed >75% pigmentation with split thickness grafting. Duration of study is over a period of one year; (12) cases were males and (10) cases were females; (1) case showed hyperpigmentation.

In our study, earliest response with split thickness skin grafting and PUVA sol therapy was noticed as early as one and a half month after grafting. One case only there was no significant response to split thickness skin grafting and PUVA sol therapy even after 9 months of completion of treatment.

Factors Influencing Outcome of Vitiligo Surgery

Thickness/Depth of the graft.

Graft margin area.

CONCLUSION

In a nut shell, surgical modality is the only option in managing resistant cases of vitiligo and can be recommended in the cosmetically conscious group between 20-40 years' age group and discourage in people beyond 50 years to undergo this manoeuvre. Split-thickness skin grafting is claimed to be the most successful tissue-grafting procedure in acral vitiligo along with photochemotherapy.

It induces faster onset of repigmentation and it is technically more demanding and gives excellent colour match in terms of texture and cosmetic appearance, area of repigmentation in both donor and recipient sites with minimal complications. It can be done in any kind of setup with minimal equipment.

REFERENCES

(1.) Mattoo SK, Handa S, Kaur I, et al. Psychiatric morbidity in vitiligo: prevalence and correlates in India. J Eur Acad Dermatol Venereol 2002;16(6):573-8.

(2.) Aghaei S, Sodaifi M, Jafari P, et al. DLQI scores in vitiligo: reliability and validity of the persian version. BMC Dermatol 2004;4:8.

(3.) Kovacs SO. Vitiligo. J Am Acad Dermatol 1998;38(5Pt1):647-66.

(4.) Falabella R.Epidermal grafting: an original technique and its original application in achronic and granulating areas. Arch dermatol 1971;104(6):592-600.

(5.) Parsad D, Gupta S. Standard guidelines of care for vitiligo surgery. Indian J Dermatol Venereol Leprol 2008;74:S37-45.

(6.) Na GY, Seo SK, Choi SK. Single hair grafting for the treatment of vitiligo. J Am Acad Dermatol 1998;38(4):580-4.

(7.) Agrawal K, Agrawal A. Vitiligo: repigmentation with dermabrasion and thin split-thickness skin graft. Dermatol Surg 1995;21(4):295-300.

(8.) Suvanprakom P, Sompong DA, Pongsomboon C, et al. Melanocyte autologous grafting for treatment of leucoderma. J Am Acad Dermatol 1985;13(6):968-74.

(9.) Kahn AM, Cohen MJ. Repigmentation in vitiligo patientsmelancocytes transfer via ultra-thin grafts. Dermatol Surg 1998;24(3):365-7.

(10.) Achauer BM, Le Y, Vander Kam VM. Treatment of vitiligo with melanocytic grafting. Ann Plast Surg 1994;33(6):644-6.

(11.) Hann SK, Im S, Bong HW, et al. Treatment of stable vitiligo with autologous epidermal grafting and PUVA. J Am Acad Dermatol 1995;32(6):943-8.

(12.) Savant SS. Surgical therapy of vitiligo: current status. Indian J Dermatol Venereol Leprol 2005;71(5):307-10.

(13.) Khunger N, Kathuria SD, Ramesh V. Tissue grafts in vitiligo surgery-past, present, and future. Indian J Dermatol 2009;54(2):150-8.

Sankara Rao K [1], D. Subba Rao [2], B. V. Ramachandra [3], G. Srinivasulu [4], N. B. Lakshmi [5]

[1] Post Graduate Final Year, Department of Dermatology, Venereology & Leprosy, Asram.

[2] Professor, Department of Dermatology, Venereology & Leprosy, Asram.

[3] Professor & HOD, Department of Dermatology, Venereology & Leprosy, Asram.

[4] Associate Professor, Department of Dermatology, Venereology & Leprosy, Asram.

[5] Assistant Professor, Department of Dermatology, Venereology & Leprosy, Asram.

Financial or Other, Competing Interest: None.

Submission 25-02-2016, Peer Review 20-03-2016, Acceptance 26-03-2016, Published 14-04-2016.

Corresponding Author:

Dr. Sankara Rao K, Bharat Pet 3rd Lane, Door.No. 4/16/17 Amaravathi Road, Guntur-522002. Guntur Dist., Andhra Pradesh.

E-mail: shankarkunchala693b@gmail.com

DOI: 10.14260/jemds/2016/372
Table 1: Sex wise Response

Sex             No. of         No. of Patients Achieving
           Patients Treated       >75% Repigmentation

Males              7                       4
Females           11                       11

Table 2: Grading of Repigmentation

Degree of Repigmentation       Number of Patients
                            Achieving Repigmentation

EXCELLENT                           15 (82%)
GOOD                                 2 (12%)
FAIR                                   --
POOR                                 1 (6%)

Table 3: Distribution of Lesions and Number of Patients and Lesions
Treated

Sl. No.      Site      Number of       Number of
           Involved     Patients    Lesions Treated

1            Lips          7               17
2            Hands         4               36
3            Feet          7               38
TOTAL                      18              91

Sl. No.      Lesions Achieving      Patients Achieving
            >75% Repigmentation     >75% Repigmentation

1                 16(94%)                 6 (86%)
2                 31(84%)                 4(100%)
3                 30(79%)                 5 (72%)
TOTAL             77(85%)                15 (84%)
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Article Details
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Author:Rao K., Sankara; Rao, D. Subba; Ramachandra, B.V.; Srinivasulu, G.; Lakshmi, N.B.
Publication:Journal of Evolution of Medical and Dental Sciences
Article Type:Report
Date:Apr 14, 2016
Words:2014
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