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A Case of Thrombus Formation in a Patient with Preserved Left Ventricle Ejection Fraction and Development of Peripheral Embolization.

Echocardiography is a substantial imaging modality for evaluating intracardiac masses. Thrombi and primary or metastatic cardiac tumors should be considered in the differential diagnosis of left ventricle (LV) masses. Thrombus formation in the LV generally occurs because of diseases that cause LV systolic dysfunction. Some cases have been reported to be related to thrombus formation in patients with a normal LV ejection fraction. Physicians should consider that a thrombus might develop in patients with a normal ejection fraction.

Keywords: Thrombus, embolization, echocardiography


Thrombus formation in the left ventricle (LV) generally occurs because of diseases that cause LV systolic dysfunction such as dilated cardiomyopathy, myocardial infarction, and aneurysm. Here we present the case of a patient with an LV thrombus and peripheral embolization and who had a normal LV systolic function.


A 63-year-old male patient with severe pain in the left leg was admitted to the emergency department. He underwent embolectomy of the right femoral artery 2 weeks ago at another hospital. The patient's physical examination was quite normal, except for the absence of left popliteal and distal pulses. His blood pressure was 113/67 mmHg, with a pulse rate of 67 beats/min. Electrocardiogram revealed a normal sinus rhythm. The ejection fraction of LV was 65%, and a mobile, pedunculated heterogeneous mass originating from the interventricular septum and measuring 1.3x1.1 cm in diameter was observed on echocardiography (Figure 1). It was primarily considered to be a myxoma rather than a thrombus. Peripheral angiography was performed, and acute 100% obstruction was detected at the left femoral artery on an angiogram. Therefore, emergency left femoral embolectomy was performed by cardiovascular surgeons. Histopathology of the embolectomy specimen was relevant with a thrombus. Thus, echocardiography was repeated, and a 4-mm-sized residual mass was detected 3 days after the surgery (Figure 2). Factor V Leiden and prothrombin 20210 mutation tests were negative, and protein C and S and antithrombin 3 levels and eosinophil counts were all normal. Moreover, tests for Antinuclear anticore level and lupus anticoagulants were negative. The patient was anticoagulated with warfarin, with a target INR of 2-3. The patient's consent was obtained.


Echocardiography is a substantial imaging modality for evaluating intracardiac masses. Thrombi and primary or metastatic cardiac tumors should be considered in the differential diagnosis of LV masses (l-6). Myxoma was primarily considered to be the diagnosis because of a mobile, pedunculated mass in a normal functioning LV, although, with a low probability, our differential diagnosis included a thrombus (7).

Protein C and S deficiency, antiphospolipid syndrome, myeloproliferative disorders, idiopathic hypereosinophilic syndrome, pheochromocytoma, and Takatsubo cardiomyopathy were reported to be related with thrombus formation in patients with a normal LV ejection fraction (8-10).

Clinical and laboratory findings of our case were all normal. LV thrombus formation and peripheral embolization are extremely rare in patients with a normal ejection fraction and without any etiologic cause, as in our case (7).

Physicians should be careful regarding LV thrombus or mass formation in patients with a history of systemic embolus. Furthermore, it should be considered that a thrombus might develop in patients with a normal ejection fraction.

Informed Consent: Informed consent was obtained from the patient who participated in this study.

Peer-review: Externally peer-reviewed.

Author contributions: Concept - Z.E.; Design - Z.E., N.B.; Supervision - N.B., S.A; Resource - N.B.; Materials - Z.E.; Data Collection and/or Processing - Z.E., S.A.; Analysis and/or Interpretation - S.A.; Literature Search - Z.E., N.B.; Writing - Z.E., N.B.; Critical Reviews - S.A.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.


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(9.) Matitiau A, Tabachnik E, Sthoeger D, Birk E. Thrombus in the left ventricle of a child with systemic emboli: an usual presentation of hereditary protein C deficiency. Pediatrics 2001; 107: 421-2. [CrossRef]

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Zehra Erkal, Nermin Bayar, Sakir Arslan

Department of Cardiology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey

Corresponding Author: Zehra Erkal


Cite this article as: Erkal Z, Bayar N, Arslan S. A case of thrombus formation in a patient with preserved left ventricle ejection fraction and development of peripheral embolization. Cyprus J Med Sci 2017; 2: 38-9

Received: 16.10.2016

Accepted: 15.05.2017
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Title Annotation:Case Report
Author:Erkal, Zehra; Bayar, Nermin; Arslan, Sakir
Publication:Cyprus Journal of Medical Sciences
Article Type:Case study
Date:Aug 1, 2017
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