1. Advances in structure elucidation of mistletoe constituents.
Recently, structure biology studies and X-ray crystallography of the various isoforms of mistletoe lectins, which belong to the type II ribosome-inactivating proteins (RIPII), have led to new insights into substrate preferences and substrate binding. For example, the complete primary structure of the A chain of mistletoe lectin III has been elucidated and the structures of mistletoe lectin I complexed with lactose and galactose have been determined. This knowledge will give further information about the mechanisms of lectin-standardized mistletoe therapy. Recent advances in the particular field of structure elucidation of lectins will be reviewed in some detail.
Keywords: Viscum album; X-ray; Crystal structure; Lectins; Flavonoids; Structure biology; Galactose; Lactose; Structure elucidation
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|Publication:||Phytomedicine: International Journal of Phytotherapy & Phytopharmacology|
|Article Type:||Brief article|
|Date:||Oct 1, 2007|
|Next Article:||2. Effects of mistletoe extracts on immunocompetent cells in vitro and in vivo.|