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...When melded with gene transfer.

For a different twist on gene and antisense therapies, Jack A. Roth at the University of Texas M.D. Anderson Cancer Center in Houston packages antisense in a disabled mouse leukemia virus, much as gene therapists use viruses to transfer genes. In a planned study of 14 people with advanced lung cancer, Roth and his colleagues will administer virus containing either antisense or a functional tumor-suppressor gene, p53. The antisense will block the activity of a tumor-promoting gene in patients whose tumors contain mutations in this oncogene. The other treatment will restore p53 function to those whose tumors lack p53 or contain mutations in that gene, Roth says.
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Title Annotation:use of antisense technology to pass genetic material to suppress tumor activity
Author:Pennisi, Elizabeth
Publication:Science News
Article Type:Brief Article
Date:Jun 5, 1993
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