"Supermice" run faster, live longer.
This remarkable transformation is all the more amazing given that it's due to a modification to a single metabolism gene shared with humans. The modification causes the mice to express in skeletal muscle an enzyme called phosphoenolpyruvate carboxykinase (PEPCK-C), which is normally found in liver and adipose tissue and is involved in energy metabolism. This "overexpression" promotes an unusually high concentration of mitochondria and triglycerides, which crowd within muscle cells, providing extraordinary muscular performance.
"Overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity," researchers concluded.
* Hakimi P, Yang J, Casadesus G, et al. Over-expression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007 Nov 9;282(45):32844-55.
|Printer friendly Cite/link Email Feedback|
|Title Annotation:||IN THE NEWS|
|Date:||Apr 1, 2008|
|Previous Article:||Supplement users tend to weigh less, experience less hunger.|
|Next Article:||Lower vitamin D levels linked to greater knee arthritis pain.|
|Growth-gene mickey makes mice mini.|
|Media Consistently Misses Decline in Number of Abortions.|
|ROI for CI--one firm's perspective: real results for competitive intelligence.|