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"Phthalates": Kelley et al. respond.

We appreciate Carter's review of our article (Kelley et al. 2012) and his further clarification of the chemistry across this class of compounds. In the "Results" of our article, we specifically noted the use of ortho-phthalates (DBP and DEP), which were often found to be used in combination with the phthalate polymers he discussed in his letter [cellulose acetate phthalate (CAP), hypromellose phthalate (HMP), and polyvinyl acetate phthalate (PVAP)]. We believe that we appropriately distinguished the difference between the ortho-phthalates and the polymers, specifically noting that the polymers have "no known toxicity."

K.E.K and A.A.M. are employed by and E.L.C. was previously associated with the Slone Epidemiology Center, which receives funding for unrelated research from various pharmaceutical companies. S.H.D. and A.A.M. have received unrestricted research and training grants from pharmaceutical companies, some of which manufacture drugs discussed in this article. The remaining author declares he has no actual or potential competing financial interests.


Kelley KE, Hernandez-Diaz S, Chaplin EL, Hauser R, Mitchell AA. 2012. Identification of phthalates in medications and dietary supplement formulations in the United States and Canada. Environ Health Perspect 120:379-384.

Katherine E. Kelley Erica L. Chaplin Allen A. Mitchell

Slone Epidemiology Center at Boston University Boston, Massachusetts E-mail:

Sonia Hernandez-Diaz

Department of Epidemiology Harvard School of Public Health Boston, Massachusetts

Russ Hauser

Department of Environmental Health Occupational and Environmental Medicine and Epidemiology Program Harvard School of Public Health Boston, Massachusetts

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Title Annotation:Correspondence
Author:Kelley, Katherine E.; Chaplin, Erica L.; Mitchell, Allen A.; Hernandez-Diaz, Sonia; Hauser, Russ
Publication:Environmental Health Perspectives
Article Type:Viewpoint essay
Date:Nov 1, 2012
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