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Wrinkles and Retin-A.



Wrinkles and Retin-A

Tretinoin tretinoin /tret·i·noin/ (tret´i-noin?) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute  (brand name Retin-A) -- the prescription anti-acne ointment ointment /oint·ment/ (oint´ment) a semisolid preparation for external application to the skin or mucous membranes, usually containing a medicinal substance.

oint·ment
n.
 that appears to reverse signs of skin aging -- reduces wrinkles, softens skin and lightens pigment spots for at least 16 months in patients who continue using the cream, researchers report.

"What we find in general is that the longer we go, the more improvement we get," says John Voorhees, chairman of the department of dermatology at the University of Michigan (body, education) University of Michigan - A large cosmopolitan university in the Midwest USA. Over 50000 students are enrolled at the University of Michigan's three campuses. The students come from 50 states and over 100 foreign countries.  Medical Center in Ann Arbor. Voorhees coauthored the original, widely reported, four-month study in the Jan. 22 JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION JAMA: The Journal of the American Medical Association is an international peer-reviewed general medical journal, published 48 times per year by the American Medical Association. JAMA is the most widely circulated medical journal in the world. , in which Retin-A use was associated with "significant improvement" in sun-damaged or "photoaged" skin (SN: 1/30/88, p.71). He and other researchers presented new data last week in Philadelphia at a conference on skin aging at Jefferson Medical College.

So far, Voorhees says, the most serious side effect is transient skin irritation skin irritation,
n reaction to a particular irritant that results in inflammation of the skin and itchiness.
, which usually subsides "after a couple of weeks." Long-term toxicity, however, has yet to be determined. Also unknown: how the cream works, what the minimum effective dose is, how long the benefits may last after treatment stops and whether the drug helps prevent skin cancer.
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Title Annotation:anti-acne ointment
Publication:Science News
Date:May 28, 1988
Words:193
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