Wrinkle Reduction Reported in Clinical Study of Solution Containing Human Growth Factors.Business Editors & Health/Medical Writers BIOWIRE2K LA JOLLA, Calif.--(BW HealthWire)--May 14, 2001 Advanced Tissue Sciences, Inc., (NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on : ATIS ATIS - A Tools Integration Standard ) reported a reduction in facial wrinkles in studies of patients treated with a topical solution containing growth factors derived from the company's human tissue-engineered skin. The results of two studies were described at the Society of Investigative Dermatology meeting in Washington, DC on May 12, 2001. The data suggest that such enriched solutions may be beneficial in the remodeling remodeling /re·mod·el·ing/ (re-mod´el-ing) reorganization or renovation of an old structure. bone remodeling and regeneration of skin, thereby reducing the appearance of visible wrinkles. In the first study, 14 patients with moderately wrinkled skin used a daily application of NouriCel(TM), an enriched nutrient solution containing human growth factors derived from Advanced Tissue Sciences' tissue-engineered skin. Nine of 14 patients (64%) had visible improvements in at least one of four areas with an average decrease in wrinkle depth of approximately 27% after treatment for 60 days. An additional study of 16 volunteers analyzed biopsies of treated areas taken at the conclusion of a 30-day NouriCel trial. Results showed a 50-80% increase in Grenz zone grenz zone a zone of relatively normal collagen demarcating the boundary between normal epidermis and a dermal lesion such as a granuloma or a neoplasm. collagen (upper dermal dermal /der·mal/ (der´mal) pertaining to the dermis or to the skin. der·mal or der·mic adj. Of or relating to the skin or dermis. collagen) in two of the three formulations designed to optimize growth factor penetration. Computerized measurement of tissue density and texture showed a 42-53% increase in newly deposited fine matrix fibers. These results are consistent with in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. studies which showed a statistically significant increase in fibroblast fibroblast /fi·bro·blast/ (fi´bro-blast) 1. an immature fiber-producing cell of connective tissue capable of differentiating into chondroblast, collagenoblast, or osteoblast. 2. and keratinocyte keratinocyte /ke·rat·i·no·cyte/ (ker-at´in-o-sit) the epidermal cell that synthesizes keratin, known in its successive stages in the layers of the skin as basal cell, prickle cell, and granular cell. proliferation, collagen deposition, and antioxidant antioxidant, substance that prevents or slows the breakdown of another substance by oxygen. Synthetic and natural antioxidants are used to slow the deterioration of gasoline and rubber, and such antioxidants as vitamin C (ascorbic acid), butylated hydroxytoluene activity after application of NouriCel. "NouriCel is part of our effort to pursue more near-term opportunities such as the large cosmeceuticals market for products to treat aging skin," said Gail Naughton, Ph.D., President of Advanced Tissue Sciences. NouriCel is being evaluated as an additive in cosmetics including skin, hair, and nail products to potentially enhance aesthetic outcomes. NouriCel is derived from the nutrient solutions used to nourish three-dimensional human tissues in the manufacturing process developed by Advanced Tissue Sciences for its line of human tissue-engineered products. As tissues are grown, the nutrient solution collects soluble growth factors, collagens, and antioxidants Antioxidants Substances that reduce the damage of the highly reactive free radicals that are the byproducts of the cells. Mentioned in: Aging, Nutritional Supplements antioxidants, n. produced by neonatal cells. The result is an enriched nutrient solution containing the complex array of factors found in newborn skin but present in lower amounts as skin matures or cells are damaged by chemicals and sunlight (resulting in wrinkles, sagging, and pigmentation pigmentation, name for the coloring matter found in certain plant and animal cells and for the color produced thereby. Pigmentation occurs in nearly all living organisms. changes). Advanced Tissue Sciences is a tissue engineering company utilizing its proprietary core technology to develop and manufacture human-based tissue products for tissue repair and transplantation. For more information on Advanced Tissue Sciences, visit the company web site at: www.advancedtissue.com. Statements in this press release that are not strictly historical may be "forward-looking" statements, which involve risks and uncertainties. No assurances can be given, for example, that the company will successfully implement its business strategy, develop its current products, or any new products it may pursue, complete clinical trials, obtain regulatory approvals (or that any such approvals will be obtained on a timely basis), or be able to manufacture or successfully commercialize such products. Risks and uncertainties that exist in the company's operations, include, without limitation, uncertainties related to the ability to obtain additional financing to continue operations when needed, a history of operating losses and accumulated deficits, market acceptance of products, the company's reliance on collaborative relationships, the company's ability to obtain and retain patent protection, as well as other risks detailed from time to time in publicly available filings with the Securities and Exchange Commission including, without limitation, Advanced Tissue Sciences' Annual Report on Form 10-K for the year ended December 31, 2000. The company undertakes no obligation to release publicly the results of any revision to these forward-looking statements to reflect events or circumstances arising after the date hereof. |
|
||||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion