Whatman Protein Biochip Receives CE Registration for Diagnosis of Autoimmune Diseases.Groundbreaking Diagnostic Chip Allows Research Laboratories To Generate Multiple Quantitative Results From A Single Sample, May Help Scientists Discover Relationships Between Diseases FLORHAM PARK, N.J. -- Whatman plc, a global leader in separations and protein array technology, today announced that its multiplex See multiplexing. protein biochip biochip Small-scale device, analogous to an integrated circuit, constructed of or used to analyze organic molecules associated with living organisms. One type of theoretical biochip is a small device constructed of large organic molecules, such as proteins, and capable of , branded CombiChip(R), has received CE Registration for the detection of autoimmune diseases Autoimmune diseases A group of diseases, like rheumatoid arthritis and systemic lupus erythematosus, in which immune cells turn on the body, attacking various tissues and organs. Mentioned in: Complement Deficiencies, Premature Menopause . This novel assay system was developed in a partnership with Privates Institut fur Immunologie und Molekulargenetik GmbH (IIM IIM Indian Institute of Management (main Management Institutes of India) IIM Individual Indian Money (US Department of Interior) IIM Industrial Information Management ), a premier German laboratory that specializes in autoimmune and other clinical diagnostic assays. Whatman/Schleicher & Schuell plans to make the CombiChip available to reference laboratories as a CE-marked in-vitro diagnostic kit. "Conventional methods of autoimmune diagnosis rely on single ELISAs, Immunoblots or Farr/Crithidia assays for each different analyte," explained Dr. Appelhans, General Manager at IIM. "This protein biochip for autoimmune detection will be a major step forward for our lab and others, because the ability to generate multiple results from a single sample significantly reduces the time, effort and cost of autoimmune analysis. After the promising results of our validation study, we plan to use this assay in our daily routine." The biochip, which only requires a single, low volume serum sample to generate results for 14 different analytes, effectively reduces the time of analysis to two or three hours. Additionally, in contrast to other diagnostic assays that rely on "Yes/No" determinations, the CombiChip uses an IgG concentration calibrator calibrator an instrument for dilating a tubular structure or for determining the caliber of such a structure. to quantitatively measure the presence of autoantibodies for each single patient's sample. Currently, the chip identifies antibodies associated with approximately 10 different collagenosis and vasculitis-related autoimmune diseases, including systemic and neonatal lupus lupus (l  `pəs), noninfectious chronic disease in which antibodies in an individual's immune system attack the body's own substances. and systemic sclerosis Systemic sclerosisA rare disorder that causes thickening and scarring of multiple organ systems. Mentioned in: Scleroderma systemic sclerosis . "The CE registration of our CombiChip is a major breakthrough in the field of diagnostics," said Martin Tricarico, Vice President of Business Development. "By analyzing several diseases at once, this pioneering work offers researchers more than savings - it offers them the ability to investigate interactions and relationships between autoimmune diseases. In this way, researchers may discover disease groupings that they had never considered. We expect that this chip will open up a wealth of further application opportunities in clinical diagnostics." About Whatman A global leader in separations technology, Whatman provides innovative life science products and solutions for the scientific community. Whatman has developed total sample preparation solutions through our robust line of filtration devices and membranes. Our breakthrough protein array technology, coupled with unique innovations in capturing, archiving and purifying pu·ri·fy v. pu·ri·fied, pu·ri·fy·ing, pu·ri·fies v.tr. 1. To rid of impurities; cleanse. 2. To rid of foreign or objectionable elements. 3. DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. at room temperature, enable us to provide novel solutions for the analytical, health care, and bioscience markets. For more information visit us at www.whatman.com. |
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