We Each Live in Our Own Little World -- Smellwise.
A pair of studies appearing online on August 1 in the journal Current Biology, a Cell Press publication, now identifies the genetic differences that underpin the differences in smell sensitivity and perception in different individuals. The researchers tested nearly 200 people for their sensitivity for ten different chemical compounds that are commonly found in foods. They then searched through the subjects' genomes for areas of the DNA DNA: see nucleic acid.
or deoxyribonucleic acid
One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. that differed between people who could smell a given compound and those who could not. This approach -- known as a genome-wide association study -- is widely used to identify genetic differences. The researchers, led by Sara Jaeger jaeger (yā`gər), common name for several members of the family Stercorariidae, member of a family of hawklike sea birds closely related to the gull and the tern. The skua is also a member of this family. , Jeremy McRae, and Richard Newcomb of Plant and Food Research in New Zealand New Zealand (zē`lənd), island country (2005 est. pop. 4,035,000), 104,454 sq mi (270,534 sq km), in the S Pacific Ocean, over 1,000 mi (1,600 km) SE of Australia. The capital is Wellington; the largest city and leading port is Auckland. , found that for four of the ten odors tested, there was indeed a genetic association, suggesting that differences in the genetic make-up determine whether a person can or cannot smell these compounds. The smells of these four odorants are familiar, for those who can smell them (though their names may not be): malt (isobutyraldehyde), apple (EAA-damascenone), blue cheese (2-heptanone), and EAA-ionone, which smells floral to some people and is particularly abundant in violets. "We were surprised how many odors had genes associated with them. If this extends to other odors, then we might expect everyone to have their own unique set of smells that they are sensitive to. These smells are found in foods and drinks that people encounter every day, such as tomatoes and apples. This might mean that when people sit down to eat a meal, they each experience it in their own personalized way," says Jeremy McRae. When McRae and colleagues compared the differences in sensitivities between human populations in different parts of the world, they found no sign of regional differentiation. This means that, for instance, a person in Asia is just as likely to be able to smell one of these compounds as someone in Europe or Africa. What's more, the ability to smell one of the compounds doesn't predict the ability to smell the other. So, if you are good at smelling blue cheese, it doesn't mean you're necessarily good at smelling the apple next to it. So, which are the genes that determine our ability to perceive certain odors? McRae and colleagues found that the genetic variants associated all lie in or near genes that encode so-called odorant odorant /odor·ant/ (o´der-int) any substance capable of stimulating the sense of smell.
odorant or olfactory olfactory /ol·fac·to·ry/ (ol-fak´ter-e) pertaining to the sense of smell.
Of, relating to, or contributing to the sense of smell. receptors. The odorant receptor molecules sit on the surface of sensory nerve sensory nerve
An afferent nerve conveying impulses that are processed by the central nervous system to become part of the organism's perception of itself and of its environment. cells in our nose. When they bind a chemical compound drifting through the air, the nerve cell sends an impulse to the brain, leading ultimately to the perception of a smell. In the case of EAA-ionone, the smell associated with violets, McRae and colleagues managed to pinpoint the exact mutation (a change in the DNA sequence) in the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note -- people who are less good at smelling EAA-ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasant. "Knowing the compounds that people can sense in foods, as well as other products, will have an influence on the development of future products. Companies may wish to design foods that better target people based on their sensitivity, essentially developing foods and other products personalized for their taste and smell," says Richard Newcomb. So, next time you are buying violets for your sweetheart, you can see if he or she can smell them and perform your own ad hoc genetic test.
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