Warning against Tenofovir+ddI+3TC, and "Triple Nuke" combinations.On October 14, 2003 Gilead Sciences warned health care professionals against a using ddI plus 3TC plus tenofovir combination, after many patients on that regimen failed to control the virus and developed mutations to the drugs. The "dear doctor" letter, "High Rate of Virologic Failure in Patients with HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. Infection Treated with a Once-Daily Triple NRTI Noun 1. NRTI - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs Regimen containing Didanosine didanosine /di·dan·o·sine/ (-dan´o-sen) 2, an analogue of dideoxyadenosine; an antiretroviral agent used for the treatment of advanced HIV-1 infection and acquired immunodeficiency syndrome, administered orally. , Lamivudine, and Tenofovir" is on the FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. Website, http://www.fda.gov/medwatch/SAFETY/2OO3/viread_deardoc.pdf The letter also cautioned against all-NRTI regimens in general, as three other such regimens showed disappointing antiviral results in clinical trials. |
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