Vitamin relative may aid stroke repair. (Biomedicine).
Vitamin C vitamin C
or ascorbic acid
Water-soluble organic compound important in animal metabolism. Most animals produce it in their bodies, but humans, other primates, and guinea pigs need it in the diet to prevent scurvy. can't pass through the so-called blood-brain barrier blood-brain barrier
n. Abbr. BBB
A physiological mechanism that alters the permeability of brain capillaries so that some substances, such as certain drugs, are prevented from entering brain tissue, while other substances are allowed to to gain entry into the brain, but its precursor, dehydroascorbic acid (DHA DHA docosahexaenoic acid.
n.pr See acid, docosahexaenoic. ), can. Thanks to this trait, DHA might help stroke patients retain the use of endangered parts of their brains, a new study finds.
When a clot shuts off blood flow to part of the brain, patients sometimes receive powerful clot-busting drugs to reopen the blocked vessel. In other people, blood finds alternate routes to threatened areas. This resurgence of blood can't save brain cells that are dead, but it can salvage nearby tissue that faces a dwindling blood supply.
Meanwhile, blood flow shut-off and restoration both unleash free radicals--highly reactive molecules that disrupt cells and complicate the capability of the smallest blood vessels, called capillaries, to nourish tissue and keep it alive.
Substances that reduce the damage of the highly reactive free radicals that are the byproducts of the cells.
Mentioned in: Aging, Nutritional Supplements
n. such as DHA and vitamin C neutralize free radicals. To assess their value in limiting stroke damage, David W. Golde of Memorial Sloan-Kettering Cancer Center The Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City is a cancer treatment and research institution founded in 1884 as the New York Cancer Hospital. The main campus is located at 1275 York Avenue, between 67th and 68th Streets, with other locations in New in New York, and his colleagues experimented with mice. The researchers modeled strokes in people by shutting off blood flow to parts of the animals' brains and then restoring it in some mice.
The mice getting DHA infusions as much as 3 hours after an induced stroke preserved function in more of the brain than did mice getting vitamin C or an inert substance, the scientists report in the Sept. 25 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES The Proceedings of the National Academy of Sciences of the United States of America, usually referred to as PNAS, is the official journal of the United States National Academy of Sciences. . Further testing is needed, but the work suggests that DHA might limit the brain area damaged by stroke, Golde says. --N.S.