Vitamin B12.Nutraceutical: Vitamin B12
Indication: Hip bone loss
Source: Journal of Endocrinology Journal of Endocrinology
This is a journal published by the Society for Endocrinology, which publishes original research articles in the field. It is abbreviated "J Endocrinol".
 & Metabolism, 2004;89(3):1217-1221.
Research: The purpose of this study was to test whether low serum vitamin B12 levels are associated with more rapid bone loss in elderly women. Researchers archived sera and measured calcaneal calcaneal /cal·ca·ne·al/ (kal-ka´ne-al) pertaining to the calcaneus.
arising from or pertaining to the calcaneus. bone mineral density bone mineral density
See bone density.
bone mineral density A measurement of bone mass, expressed as the amount of mineral–in grams divided by the area scanned in cm2. See Bone densitometry. (BMD BMD
In currencies, this is the abbreviation for the Bermudian Dollar.
The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. ) in community-dwelling white women aged 65 and older, who participated in the Study of Osteoporotic Fractures. BMD of the hip and subregions was measured two years later. Repeat measurements of calcaneal and hip BMD were obtained after almost six years and three and a half years of follow-up, respectively. Serum vitamin B12 assays were performed in 83 randomly selected participants with initial and repeat measurements of BMD who were not taking estrogen replacement therapy estrogen replacement therapy
n. Abbr. ERT
The administration of estrogen, especially in postmenopausal women, to relieve symptoms and conditions associated with estrogen deficiency, such as hot flashes and osteoporosis. at baseline.
Results: Women with vitamin B12 levels at or below 280 pg/ml experienced a total change of -1.6% in total hip BMD, compared with -.2% in women with levels above 280 pg/ml. Results were similar when subregions of the hip were analyzed separately. As a result, researchers concluded that while serum vitamin B12 levels were not significantly associated with calcaneal bone loss, low serum vitamin B12 levels were associated with increased rates of hip bone loss in older women.