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VOLUNTEERS LINE UP TO RISK LIVES FOR HIV VACCINE TEST.



Byline: Brigid Schulte Knight-Ridder Tribune News Wire

It is a terrifying ter·ri·fy  
tr.v. ter·ri·fied, ter·ri·fy·ing, ter·ri·fies
1. To fill with terror; make deeply afraid. See Synonyms at frighten.

2. To menace or threaten; intimidate.
 proposition: inject yourself with a weakened AIDS virus AIDS virus
n.
See HIV.
 in the hope it will become, not the deadly disease, but the vaccine for it.

Yet at least 50 doctors and activists this week offered themselves up as human guinea pigs, largely to protest the glacial pace of vaccine research.

The risks are enormous. The science is unclear. And, should the government approve such a trial, it is almost certain that some of the volunteers will become ill with the AIDS virus, suffer and die.

But, with 8,000 people a day becoming infected with the human immunodeficiency virus human immunodeficiency virus
n.
HIV.


Human immunodeficiency virus (HIV)
A transmissible retrovirus that causes AIDS in humans.
 - most of them in developing countries with no access to life-saving drugs and little education - and no way to stop the global AIDS pandemic Acquired Immune Deficiency Syndrome (AIDS) has led to the deaths of more than 25 million people since it was first recognized in 1981, making it one of the most destructive epidemics in recorded history.  without a vaccine, that's a risk many volunteers say they are willing to take.

@ They are meeting today with hesitant government officials and scientists to try to persuade them to approve the trial.

Among the volunteers, there are the big names: Dr. Bernard Hirschel, chairman of the 12th World AIDS Conference in Geneva Geneva, canton and city, Switzerland
Geneva (jənē`və), Fr. Genève, canton (1990 pop. 373,019), 109 sq mi (282 sq km), SW Switzerland, surrounding the southwest tip of the Lake of Geneva.
, and Jose Zuniga, who was drummed out of the Army for acknowledging he is gay.

And then there is Helen Miramonter, a nurse at the University of California, San Francisco Coordinates:  . Mother of six, two of whom are gay, and grandmother of 10, she is willing to put her life on the line.

``I'm 66, and a widow, so the decision was mine alone. I have lived a full and happy life. I hope to live a lot longer because I have a lot more work to do. But we've got young people, 15-year-olds, being infected every day,'' she said. ``We're talking about wiping out whole societies of young people just beginning their productive life. I don't think people understand the profound effect of this epidemic.''

The decision to volunteer came quickly. Miramonter worked in the civil rights and peace movements in the 1960s. She has fought for migrant workers' rights. And, in the early, fearful days of AIDS, when people were unwilling to touch AIDS patients or breathe the same air, she volunteered to nurse them in intensive care units. Now, she sits on the president's advisory council on HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.  and AIDS.

That doesn't mean she is not without fear. She has spilled infected blood on herself. And she was one of the first to volunteer to test a then-unknown vaccine for hepatitis B Hepatitis B Definition

Hepatitis B is a potentially serious form of liver inflammation due to infection by the hepatitis B virus (HBV). It occurs in both rapidly developing (acute) and long-lasting (chronic) forms, and is one of the most common chronic
, often a complication of the AIDS virus.

``It is terrifying for people, but this is just part of my responsibility, my role as a nurse,'' Miramonter said. ``Maybe that sounds Pollyanna or Mother Teresa. I'm not. I just feel that committed. And I'm part of an older generation, one that believes it's your duty to turn around and take care of the next.''

And the only way to do that with AIDS is to risk human lives in a vaccine trial. ``Even trial failures give us answers,'' she said. Even if she is that failure. ``I'll have no regrets.''

Although President Clinton in May called for a new ``Manhattan Project'' to develop an AIDS vaccine AIDS vaccine A hypothetical vaccine intended to either prevent HIV infection or ensure that those infected will not fall victim to AIDS; the most promising vaccine is that using a naked DNA plasmid, reported by Letwin et al in 20/10/00 Science; as of early 2001,  within 10 years, only a few companies are involved in developing one. And the AIDS virus is so complicated that most vaccine research only raises more questions.

``We're like a mouse on a treadmill,'' said Dr. William Heyward of the CDC See Control Data, century date change and Back Orifice.

CDC - Control Data Corporation
. ``We're running like hell, and we're going nowhere.''

Still, Heyward and other researchers say it is simply too soon to start injecting people with a weakened HIV virus.

``While we all laud the altruistic motives of the people who want to volunteer, from the perspective of the substantial safety issue raised, this is premature,'' said Dr. Anthony Fauci, who heads the National Institutes of Health's AIDS section. ``Ultimately, we may be at a point where we want to do that. But in September 1997, we're just not there.''

But Dr. Charles Farthing, 44, a Los Angeles doctor who has cared for HIV and AIDS patients with increasing frustration, disagrees. It was he who began calling for human volunteers last month - and volunteered himself - to spotlight what he calls ``timidity'' in the scientific community.

``I do not think I'm falling on my sword. I do not see myself as a martyr,'' Farthing said. ``But the other vaccines look so useless that we are morally obligated ob·li·gate  
tr.v. ob·li·gat·ed, ob·li·gat·ing, ob·li·gates
1. To bind, compel, or constrain by a social, legal, or moral tie. See Synonyms at force.

2. To cause to be grateful or indebted; oblige.
 to pursue this.

``In the worst situation, I'd be taking the same medications I give to my patients.''
COPYRIGHT 1997 Daily News
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1997, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Daily News (Los Angeles, CA)
Date:Sep 25, 1997
Words:747
Previous Article:OUTDOORS FOLK HAVE THEIR DAY; VARIETY OF ACTIVITIES SET TO CELEBRATE HUNTING AND FISHING.
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