Uterine MRI: a review of technique and diagnosis.
Magnetic resonance imaging magnetic resonance imaging (MRI), noninvasive diagnostic technique that uses nuclear magnetic resonance to produce cross-sectional images of organs and other internal body structures. (MRI 1. (application) MRI - Magnetic Resonance Imaging.
2. MRI - Measurement Requirements and Interface. ) is a commonly used technique in the workup work·up
n. Abbr. w/u
A thorough medical examination for diagnostic purposes. of obstetric and gynecologic gynecologic /gy·ne·co·log·ic/ (gi?ne-) (jin?e-kah-loj´ik) pertaining to the female reproductive tract or to gynecology. abnormalities and in the pre- and postprocedural evaluation for uterine artery embolization Uterine artery embolization (UAE) or Uterine Fibroid Embolization (UFE) is a procedure where an interventional radiologist uses a catheter to deliver small particles that block the blood supply to the fibroids. See also
Optimal MRI of the female pelvis and uterus should be performed on a high-field-strength MRI system that uses local phased-array coils. The increased signaltonoise ratio provided by the surface coils allows for small field-of-view imaging that results in higher spatial resolution. The typical imaging protocol for the uterus uses both T1-weighted (T1W) and T2-weighted (T2W) images. Axial T1W images are obtained to evaluate the uterine contour, lymph nodes, and bone marrow. We perform T2W imaging in 3 orthogonal planes. One of these planes usually shows the endometrial endometrial /en·do·me·tri·al/ (en?do-me´tre-il) pertaining to the endometrium.
n relating to the end-ometrium or cavity of the uterus. complex along with the long and short axis of the the diameter of the sphere which is perpendicular to the plane of the circle.
See also: Axis uterus to good advantage. T2-weighted imaging depicts the zonal anatomy of the uterus. Fat-suppressed T1W imaging is used to differentiate between pelvic masses that contain fat and those that contain protein or hemorrhage. Contrast enhancement is used to document the extent of endometrial carcinoma invasion or to detect the presence of necrosis in uterine leiomyomas. Dynamic contrast injection can be used in women who are considering uterine artery embolization (UAE) in order to evaluate the uterine arteries and the potential collateral gonadal gonadal
pertaining to or arising from a gonad. See also testicular, ovarian.
cords formed by epithelial cells which migrate from the mesonephric tubules in the embryo to the gonadal ridge and establish the indifferent arterial supply. (1) In the evaluation of congenital uterine anomalies, sagittal sagittal /sag·it·tal/ (saj´i-t'l)
1. shaped like an arrow.
2. situated in the direction of the sagittal suture; said of an anteroposterior plane or section parallel to the median plane of the body. T2W images should be acquired first to determine the long-axis orientation of the uterus. Subsequently, images should then be obtained parallel to the long axis of the uterus in order to show the outer uterine contour. (2)
Normal uterine anatomy
T1-weighted images show poor contrast distinction between the endo metrium and myometrium myometrium /myo·me·tri·um/ (-me´tre-um) the tunica muscularis of the uterus.myome´trial
The muscular wall of the uterus. . The zonal anatomy of the uterus has a trilaminar appearance on T2W images (Figure 1). (3) The central endometrium endometrium /en·do·me·tri·um/ (-me´tre-um) pl. endome´tria the mucous membrane lining the uterus.
n. pl. has high signal intensity secondary to mucinous mucinous /mu·ci·nous/ (mu´si-nus) resembling, or marked by formation of, mucin.
relating to, resembling or containing mucin. rich endometrial glands and stroma stroma /stro·ma/ (stro´mah) pl. stro´mata [Gr.] the matrix or supporting tissue of an organ.stro´malstromat´ic
n. pl. stro·ma·ta
1. . The endometrium varies in thickness with the menstrual cycle and meno pausal status. The endometrium may measure up to 14 mm during the secretory phase in menstruating men·stru·ate
intr.v. men·stru·at·ed, men·stru·at·ing, men·stru·ates
To undergo menstruation.
[Late Latin m women but is thinned during the follicular phase. (4) Postmenopausal women should have a homogeneous endo metrium with a width of <5 mm. (5)
The myometrium can be separated into the inner myometrium, also known as the junctional zone, and the outer myometrium (Figure 1). The junctional zone contains compact smooth muscle with a paucity of intercellular intercellular /in·ter·cel·lu·lar/ (-sel´u-lar) between or among cells.
Located among or between cells. matrix and has relatively low T2 signal intensity. The normal junctional zone measures <12 mm. (6) The outer myometrium has less compact smooth muscle and increased intercellular matrix and vessels compared with the junctional zone, which results in a higher T2 signal intensity. This zonal anatomy is best visualized during the reproductive years and may be poorly depicted or absent in prepubertal prepubertal /pre·pu·ber·tal/ (-pu´ber-tal) before puberty; pertaining to the period of accelerated growth preceding gonadal maturity. and postmenopausal women. In women taking birth control pills, the junctional zone and endo metrium are thinner than in other women and the outer myometrium is higher in signal intensity. (4)
Uterine leiomyomas are neoplasms derived from the smooth muscle cells of the myometrium. Uterine leiomyomas are common, occurring in >20% in women over 30 years of age. Most patients with uterine leiomyomas are asymptomatic. Among symptomatic patients, dysmenorrhea dysmenorrhea
Pain or cramps before or during menstruation. In primary dysmenorrhea, caused by endocrine imbalances, severity varies widely. Irritability, fatigue, backache, or nausea may also occur. and irregular menstrual bleeding are the most common complaints. Leiomyomas may be intramural, subserosal, or submucosal submucosal /sub·mu·co·sal/ (-mu-ko´sal)
1. pertaining to the submucosa.
2. beneath a mucous membrane. in location. Intramural leiomyomas are centered in the uterine wall and are the most common subtype.
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A submucosal leiomyoma has a component in the endometrial canal. An intracavitary leiomyoma is almost entirely within the endometrial canal (Figure 2). Subserosal leiomyomas are centered external to the uterus (Figure 3). Nondegenerated uterine leiomyomas have lower T2 signal intensity than the outer myometrium; in addition, they are well circumscribed circumscribed /cir·cum·scribed/ (serk´um-skribd) bounded or limited; confined to a limited space.
Bounded by a line; limited or confined. and can exhibit mass effect. On postcontrast imaging, nondegenerated uterine leiomyomas enhance homogeneously. Uterine leiomyomas can appear heterogeneous in signal intensity on T2W images and show decreased enhancement when they undergo degeneration. Some subsets of degeneration include hemorrhagic Hemorrhagic
A condition resulting in massive, difficult-to-control bleeding.
Mentioned in: Hantavirus Infections
pertaining to or characterized by hemorrhage. , fatty (lipoleiomyoma) (Figure 4), myxoid myxoid /myx·oid/ (mik´soid) mucoid.
Containing or resembling mucus; mucoid.
myxoid adjective 1. , hyaline hyaline /hy·a·line/ (hi´ah-lin) glassy and translucent.
Resembling glass, as in translucence or transparency; glassy.
1. , and cystic. (7) Leio myosarcoma may have an appearance similar to a degenerated leiomyoma, but, fortunately, leiomyosarcoma is rare. It is difficult to establish a prospective diagnosis of leiomyosarcoma in the absence of metastatic disease. In our experience, degenerated atypical leiomyomas are much more common than leiomyosarcomas.
Subserosal leiomyomas can simulate fibrous or smoothmuscle ovarian masses, such as ovarian fibromas, fibrothecomas, or Brenner tumors. Subserosal leiomyomas can be differentiated from ovarian lesions since they show a normal ipsilateral ipsilateral /ip·si·lat·er·al/ (ip?si-lat´er-al) situated on or affecting the same side.
Located on or affecting the same side of the body. ovary or a bridging vessel from the uterus to the fibroid fibroid /fi·broid/ (fi´broid)
1. having a fibrous structure; resembling a fibroma.
4. in the plural, a colloquial term for leiomyoma of the uterus. . (8) Subserosal fibroids Fibroids
Benign tumors of muscle and connective tissue that develop within or are attached to the uterine wall.
Mentioned in: Menstrual Disorders on a stalk <2 cm in width are considered a relative contraindication contraindication /con·tra·in·di·ca·tion/ (-in?di-ka´shun) any condition which renders a particular line of treatment improper or undesirable.
n. for UAE, as they may lose their connection to the adjacent uterus. (9) Submucosal fibroids can simulate endometrial masses such as endometrial polyps. Leiomyomas can be separated from polyps by evaluating their signal intensity on T2W images. Leiomyomas usually have low T2 signal intensity and have a stalk that originates within the myometrium, while polyps have heterogeneous T2 signal intensity. Submucosal and intracavitary fibroids are a common cause of infertility or miscarriages by creating an adverse environment for implantation or prohibiting sufficient blood flow to support a developing embryo.
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MRI can be used in the evaluation of patients who undergo UAE for treatment of symptomatic leiomyomas. Preoperatively, MRI can aide in selecting patients who may benefit from UAE. MRI documents the size, location, and vascularity of the fibroids. Leiomyomas that have high signal intensity on T1W images and no enhancement have a poor response to UAE. (10) Detection of a large intracavitary fibroid is a relative contraindication to UAE. Submucosal fibroids may be expelled from the uterus. (11) These women may benefit from hysteroscopic resection rather than UAE. (12) Leiomyomas that show high signal intensity on T2W imaging and homogeneous enhancement have the best response to UAE. (13) Magnetic resonance angiography Magnetic resonance angiography
A noninvasive diagnostic technique that uses radio waves to map the internal anatomy of the blood vessels.
Mentioned in: Cerebral Aneurysm
magnetic resonance angiography (MRA MRA Medical Record Administrator.
MRA Magnetic resonance angiography, see MR angiography ) can evaluate the uterine arteries and identify potential collateral arterial supply from the gonadal vessels that may need to be embolized as well. (1) MR can also identify other potential causes for a woman's signs or symptoms, such as adenomyosis adenomyosis /ad·e·no·my·o·sis/ (-mi-o´sis) benign ingrowth of the endometrium into the uterine musculature, sometimes with hypertrophy of the latter; if the lesion forms a circumscribed tumorlike nodule, it is called adenomyoma. or endometriosis.
MR findings of successful UAE include a decrease in size and enhancement of fibroids, preserved enhancement of the remainder of the uterus, and lack of visualization of the uterine arteries (Figure 5). (14) Treated fibroids have increased T1 signal and do not enhance, in keeping with hemorrhagic necrosis (Figure 5). Fibroids that continue to enhance are viable and usually grow in time and may result in recurrent symptoms. (15,16) The angiographic images should be carefully inspected for a possible cause of failure such as uterine artery revascularization or collateral arterial supply from the ovarian arteries (Figure 6).
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Adenomyosis is the presence of ectopic ectopic /ec·top·ic/ (ek-top´ik)
1. pertaining to ectopia.
2. located away from normal position.
3. arising from an abnormal site or tissue.
adj. endometrial tissue in the uterine myometrium with smooth muscle hyperplasia. Adenomyosis may be focal or diffuse, with the latter being more common. On T2W images, adenomyosis appears as a thickening of the low-signalintensity junctional zone corresponding to the smooth muscle hyperplasia (Figure 7). (17) Thickening of the junctional zone >12 mm is specific for the diagnosis, while a measurement of 8 to 12 mm is indeterminate and a measurement <8 mm excludes the diagnosis with high specificity. (18) One- to 4-mm hyperintense T2 foci within the junctional zone represent the ectopic foci of endometrial tissue and, when present, add specificity to the MR diagnosis (Figure 8). (19) MR can usually differentiate between focal adenomyosis and a leiomyoma. (20) Adenomyosis has poorly defined margins, is often oriented parallel to the endometrial stripe, contains 1- to 5-mm foci of ectopic endometrial glands, and has minimal mass effect on the endometrial canal. Leiomyomas have well-defined margins and mass effect. Adenomyosis can be treated with uterine artery embolization with the expectation that >50% of women will have significant decrease in symptoms after 2 years. (21) Successfully treated adenomyosis shows a decrease in the width of the junctional zone on MRI. (22)
Endometrial carcinoma is the most common gynecologic malignancy. Roughly 75% of endometrial carcinomas occur in postmenopausal women. Excessive estrogen stimulation is the most recognized association with endometrial cancer. Women taking tamoxifen tamoxifen (təmŏk`sĭfĕn'), synthetic hormone used in the treatment of breast cancer. Introduced in 1978, tamoxifen is used to prevent recurrences of cancer in women who have already undergone surgery to remove their tumors. are also at increased risk of endometrial cancer. The most common symptom of endometrial cancer is postmenopausal bleeding. The initial procedure of choice in the evaluation of a woman with suspected endometrial carcinoma is transvaginal sonography sonography: see ultrasound or hysteroscopy with biopsy. MR is not used to screen women for endometrial carcinoma. However, in women with biopsy-proven endometrial carcinoma, MRI can be used to determine the depth of myometrial invasion. (23) On dynamic contrastenhanced MRI, endometrial carcinoma enhances less than the subjacent subjacent /sub·ja·cent/ (sub-ja´sent) located beneath.
Below or beneath another part. myometrium. 23 Malignant adenopathy is associated with muscle-invasive endometrial carcinomas. Some surgeons use the information provided by preoperative MRI to determine the need to perform lymphadenectomy. As opposed to evaluating secondary findings of nodepositive disease (muscle invasion), it would be ideal to develop MRI techniques to both detect and characterize lymph nodes as benign or malignant in order to guide therapy. (24)
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When abnormal signal within the endometrial canal invades the junctional zone on T2W or contrast-enhanced images, then endometrial carcinoma is the likely diagnosis. The differential diagnosis of a thickened endometrial stripe without myometrial extension is superficial endometrial carcinoma, endometrial polyps, and endometrial hyperplasia. Polyps may depict a zonal phenomenon with a low T2-signal-intensity fibrous core and outer high-signal-intensity glands. Endometrial hyperplasia often has a "Swiss cheese" configuration on T2W and enhanced imaging, with internal nonenhancing cysts surrounded by enhancing glandular tissue.
Tamoxifen is used in the treatment of breast cancer. While tamoxifen exhibits antiestrogenic effects within the breast, it can also show proestrogenic activity within the endometrium. Thus, tamoxifen can produce endometrial thickening on MRI (Figure 8). Pathologically, the endometrial abnormalities associated with tamoxifen use include endometrial atrophy, hyperplasia, polypoid glandular-cystic proliferation, polyps, and endometrial cancer. (25) Endometrial sampling is often needed in these women, especially those with abnormal uterine bleeding.
Mullerian duct anomalies
The incidence of mullerian duct anomalies is approximately 1% but varies by population. In patients with infertility, it is estimated to be 3%. Most mullerian duct anomalies are thought to be sporadic or multifactorial multifactorial /mul·ti·fac·to·ri·al/ (mul?te-fak-tor´e-al)
1. of or pertaining to, or arising through the action of many factors.
2. in nature. The most widely quoted classification scheme for mullerian duct anomalies is the American Fertility Society classification that has 7 classes (Table 1). (26) A simplified framework for the discussion of mullerian duct defects consists of 3 categories: duct agenesis agenesis
Failure of all or part of an organ to develop during embryonic growth. Many forms of agenesis are lethal, such as absence of the entire brain (anencephaly), but agenesis of one organ of a pair may cause little problem. and hypoplasia hypoplasia /hy·po·pla·sia/ (-pla´zhah) incomplete development or underdevelopment of an organ or tissue.hypoplas´tic
enamel hypoplasia , defects of vertical fusion of the ducts with the ascending urogenital sinus, and defects of lateral duct fusion. (27)
Patients with mullerian duct anomalies may manifest with primary amenorrhea in the adolescent age group. MRI can evaluate for the presence or absence of the vagina, cervix, or uterus and also depicts any associated renal anomalies (Figure 9). MRI can show the level of obstruction of antegrade menstrual flow in women with functioning endometrium as well as depict findings of retrograde menstruation such as hematosalpinx or endometriosis. In the reproductive years, women with uterine anomalies may present with spontaneous abortion, premature delivery, and abnormal fetal lie.
[FIGURE 9 OMITTED]
Absence of the mullerian ducts (agenesis and hypoplasia)
Mayer-Rokitansky-Kuster-Hauser syndrome represents failure of vaginal development with varying degrees of cervical and uterine agenesis/hypo plasia. In 90% of cases, there is complete uterine agenesis. In the remaining 10% of cases, there may be an ob structed or small rudimentary uterus. The ovaries are usually normal. Mayer-Rokitansky-Kuster-Hauser syndrome is the most common cause of amenorrhea amenorrhea (āmĕn'ərē`a, əmĕn'–), cessation of menstruation. Primary amenorrhea is a delay in or a failure to start menstruation; secondary amenorrhea is an unexpected stop to the menstrual cycle. in women with breast development, reflecting the normal ovarian development with this condition. A rudimentary uterus may contain functioning endometrial tissue. MRI can be used to detect associated abnormalities such as endometriosis, renal anomalies, and collecting system abnormalities (Figure 9). (28) The differential diagnosis of primary amenorrhea with normal breast development and an absent uterus includes androgen insensitivity syndrome Androgen insensitivity syndrome (AIS, or "Androgen resistance syndrome") is a set of disorders of sexual differentiation that results from mutations of the gene encoding the androgen receptor. It has also been called androgen resistance in the medical literature. ; affected individuals have rudimentary testes and absent ovaries on MR.
Unicornuate uterus is a type of uterine hypoplasia in which there is incomplete or absent development of 1 mullerian duct and represents 20% of mullerian duct anomalies. The abnormal uterine horn can be completely absent (one third of cases) or rudimentary (two thirds of cases). Of those patients with a rudimentary horn, 50% do not contain an endometrial canal and 50% have an endometrial-lined cavity. The endometrial lined cavity within a rudimentary horn communicates with the contralateral horn in approximately one third of women. (27) A unicornuate uterus is usually an incidental finding unless a cavitary rudimentary horn is present. These women can present with nonviable nonviable /non·vi·a·ble/ (-vi´ah-b'l) not capable of living.
Not capable of living or developing independently. Used especially of an embryo or fetus. pregnancy, endometriosis, or ectopic pregnancy. Therefore, rudimentary horns that contain endometrium, whether they are communicating or noncommunicating, are usually removed. Among all of the mullerian duct anomalies, unicornuate uteri have the highest association of renal abnormalities, present in up to 40% of these women. The renal anomaly is ipsilateral to the abnormal horn. MRI shows a banana-shaped uterus. (29) When the endometrium is absent, the horn is of low T2 signal intensity, with loss of normal zonal anatomy. When the endometrium is present, zonal anatomy may be preserved.
Disorders of vertical fusion (vaginal septum septum /sep·tum/ (sep´tum) pl. sep´ta [L.] a dividing wall or partition.
alveolar septum interalveolar s. )
A transverse vaginal septum consists of a band of fibrous connective tissue Fibrous connective tissue
Dense tissue found in various parts of the body containing very few living cells.
Mentioned in: Corneal Transplantation with vascular and muscular components. It is the most common disorder of vertical fusion. A transverse vaginal septum can occur anywhere along the vagina, but most commonly occurs at the junction of the upper and middle third. Patients typically present with primary amenorrhea. In patients with a uterus and functioning endometrium, hemato colpos can be depicted with MR with less severe dilation of the endometrial cavity. (27) This finding is secondary to the decreased compliance of the more muscular myometrium. A transverse vaginal septum can be present in conjunction with other mullerian duct anomalies. The most common association is a uterus didelphys and complex duplication anomalies. The differential diagnosis for primary amenorrhea with a present uterus includes an imperforate hymen, which can also cause hematocolpos. Imperforate hymen is not a mullerian anomaly, and distinction from a transverse vaginal septum can be difficult--although the treatment is similar.
Disorders of lateral fusion
Disorders of lateral fusions result in varying degrees of duplication of the uterus and cervix. Possibilities include didelphys, septate uterus, and bicornuate uterus. With a septate uterus (Figure 10), a fibromuscular central septum is incompletely resorbed after mullerian duct fusion. The septate uterus represents approximately 55% of mullerian duct anomalies. Septate septate /sep·tate/ (sep´tat) divided by a septum.
Divided by a septum or septa.
divided by a septum or septa. uteri may result in first trimester miscarriages caused by implantation on the septum. Reproductive outcome improves after hysteroscopic resection of the septum. In uterine didelphys (Figure 11), there is complete separation of distinct left and right uteri and accounts for 5% of mullerian duct anomalies. The cervix is usually duplicated as well. Women with uterine didelphys have normal or nearly normal fertility. The bicornuate uterus is caused by incomplete fusion of the uterovaginal horns at the level of the fundus fundus /fun·dus/ (fun´dus) pl. fun´di [L.] the bottom or base of anything; the bottom or base of an organ, or the part of a hollow organ farthest from its mouth. and represents approximately 10% of mullerian duct anomalies.
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Differentiating between the lateral fusion anomalies has important implications for treatment decisions. For instance, a septate uterus is often treated with hysteroscopic resection of the septum, while women with bicornuate bicornuate /bi·cor·nu·ate/ (-kor´nu-at) having two horns or cornua.
1. Having two horns or horn-shaped parts.
2. Shaped like a crescent. uteri are treated with a transabdominal metroplasty if they have a history of repeated pregnancy loss. The key in imaging lateral fusion anomalies is the evaluation of the external uterine fundal contour. The best imaging plane for evaluation of the fundal contour is one that passes through the long axis of the uterus. In a normal or septate uterus, the outer contour is convex, flat, or <10 mm of concavity con·cav·i·ty
A hollow or depression that is curved like the inner surface of a sphere.
n 1. the condition of being concave.
n 2. . The myometrial fundal indentation in·den·ta·tion
A notch, a pit, or a depression. is smooth and broad, and the signal intensity of this region is isointense to normal myometrium. The outer contour concavity of a bicornuate uterus or uterine didelphys, to the contrary, should be >10 mm. Two measurements that may be helpful include the intercornual distance and the intercornual angle. In a septate uterus, the intercornual distance is <4 cm and the intercornual angle is <60[degrees], as compared with the bicornuate uterus, in which these values are >4 cm and >60[degrees], respectively. (30,31) Lateral fusion anomalies may also result in vaginal duplication. Vertical vaginal septa septa /sep·ta/ (sep´tah) [L.] plural of septum.
Septum (plural, septa)
The dividing partition in the nose that separates the two nostrils. It is composed of bone and cartilage. are present in 75% of women with didelphys, 25% with bicornuate, and 5% with septate uteri.
Because of its superb soft tissue contrast and direct multiplanar capabilities, MRI can detect and characterize normal uterine anatomy and focal and diffuse uterine conditions. In patients with primary amenorrhea, MRI can be used to confirm the absence or presence of the uterus as well as evaluate for any associated urogenital urogenital /uro·gen·i·tal/ (-jen´i-tal) genitourinary.
u·ro·gen·i·tal or u·ri·no·gen·i·tal
Genitourinary. abnormalities such as renal agenesis. In patients with infertility, MRI can confirm the presence and extent of a septate uterus and define the fibrous and muscular components. In patients with pelvic pain, MRI is more sensitive and specific than ultrasound for the findings of adenomyosis. In patients with known leiomyomas, MRI is used in the preoperative evaluation for uterine artery embolization. In oncology, MRI can be used to stage women with known endometrial carcinoma. Understanding the appearance of the common pathologic entities involving the uterus along with the strengths and limitations of MRI will help radiologists be more confident in their approach to pelvic MR interpretation.
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(15.) Pelage pelage /pel·age/ (pel´ahj) [Fr.]
1. the hairy coat of mammals.
2. hairs of the body, limbs, and head collectively.
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(16.) Marret H, Alonso AM, Cottier Cot´ti`er
n. 1. In Great Britain and Ireland, a person who hires a small cottage, with or without a plot of land. Cottiers commonly aid in the work of the landlord's farm.
Noun 1. JP, et al. Leiomyoma recurrence after uterine artery embolization. J Vasc Interv Radiol. 2003;14:1395-1399.
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(26.) The American Fertility Society classifications of adnexal adnexal /ad·nex·al/ (ad-nek´sal) pertaining to adnexa.
pertaining to, or emanating from, the adnexa.
adnexal tumors adhesions, distal tubal Tubal (t`bəl), in the Bible, son of Japheth. obstruction, tubal occlusion secondary to tubal ligation, tubal pregnancies, mullerian anomalies and intrauterine adhesions. Fertil Steril. 1988;49:944-955. Comment in: Fertil Steril. 1989;51:199-201.
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Dr. Sydow is a Radiologist, Northside Radiology Associates, Atlanta, GA. At the time this article was written, Dr. Sydow was a radiology Resident at the Hospital of the University of Pennsylvania (body, education) University of Pennsylvania - The home of ENIAC and Machiavelli.
Address: Philadelphia, PA, USA. . Dr. Seigelman is an Associate Professor, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA.
Brian D. Sydow, MD, and Evan S. Seigelman, MD
Table 1. American Fertility Society classification scheme (26) Class I Segmental agenesis and variable degrees of uterovaginal hypoplasia Class II Unicornuate uteri Class III Uterus didelphys Class IV Bicornuate uterus Class V Septate uterus Class VI Arcuate uteri Class VII Sequela of in uteri DES exposure DES = diethylstilbestrol