United States : Hutchinson Center researcher secures $7.9 million NCI grant for esophageal cancer research.Byline: pinto03 Thomas Vaughan Thomas Vaughan may refer to:
n. Chronic peptic ulcer of the lower esophagus due to the presence of columnar epithelium resembling the mucosa of the gastric cardia. and esophageal adenocarcinoma adenocarcinoma: see neoplasm. , a rapidly fatal cancer whose incidence has increased more than 500 percent in the past 30 years, faster than any other cancer in the United States. Vaughan and David Whiteman, Ph.D., a senior research fellow at Queensland Institute of Medical Research The Queensland Institute of Medical Research (QIMR) is one of the largest medical research institutes in the southern hemisphere, and is recognised worldwide for the quality of its research. QIMR was established in 1945 by the State Government in Queensland. in Brisbane, Australia, will execute a large-scale genome-wide association study A genome-wide association study (GWAS) is an examination of genetic variation across the human genome, designed to identify genetic associations with observable traits, such as blood pressure or weight, or why some people get a disease or condition. using pooled data and DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. from 18 epidemiological studies of more than 7,000 individuals making up the Barrett's and Esophageal Adenocarcinoma Consortium to determine how genetic factors interplay with key environmental and personal risk factors for these conditions, including obesity, heartburn heartburn, burning sensation beneath the breastbone, also called pyrosis. Heartburn does not indicate heart malfunction but results from nervous tension or overindulgence in food or drink. and smoking. "The results will aid us in identifying the biological pathways that contribute to this cancer," Vaughan said. "The information also will help direct our screening, prevention and surveillance efforts to those at highest risk." The Hutchinson Center's Genomics Resource will do the genotyping for the study, their largest project to date. Bruce Weir, Ph.D., professor and chairman of the Department of Biostatistics at the University of Washington School of Public Health will lead the statistical analysis team. Genome-wide association studies involve a scan of hundreds of thousands of genetic markers across the genome in large numbers of individuals to find genetic variations associated with a particular disease. Early genome-wide scans have demonstrated considerable success in identifying genetic variants associated with common diseases. Copyright : Euclid Infotech Pvt. Ltd. Provided by Syndigate.info an Albawaba.com company |
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