Understanding the Issues Relating to Chirality in Drug Research.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c43175) has announced the addition of Chirality chirality (kī·ralˑ·i·tē), n the “handedness” property of organic compounds (containing an asymmetrical carbon) that gives rise to structures that in Drug Research to their offering. This practice-oriented handbook highlights all issues relating to relating to relate prep → concernant relating to relate prep → bezüglich +gen, mit Bezug auf +acc chirality of pharmaceuticals, from challenges in the synthesis of these complex molecules to analytical techniques to aspects of pharmacology and drug development. It is highly useful for every medicinal chemist involved in small molecule drug development. Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral chi·ral adj. Of or relating to the structural characteristic of a molecule that makes it impossible to superimpose it on its mirror image. chi·ral drugs from natural sources, their production in enzymatic processes and the resolution of racemic racemic /ra·ce·mic/ (ra-se´mik) optically inactive, being composed of equal amounts of dextrorotatory and levorotatory isomers. ra·ce·mic adj. Abbr. mixtures in preparative pre·par·a·tive adj. Serving or tending to prepare or make ready; preliminary. n. Something that prepares for or acts as a preliminary to something following. chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis Quantitative Analysis A security analysis that uses financial information derived from company annual reports and income statements to evaluate an investment decision. Notes: , enantioselective chromatographic chro·mat·o·graph n. An instrument that produces a chromatogram. tr.v. chro·mat·o·graphed, chro·mat·o·graph·ing, chro·mat·o·graphs To separate and analyze by chromatography. methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists. INTRODUCTION Chiral drugs from a historical point of view (J. Gal) SYNTHESIS Stereoselective synthesis of chiral drugs (H. Federsel) Chiral drugs from natural source (F. Petersen) Biotransformation biotransformation /bio·trans·for·ma·tion/ (-trans?for-ma´shun) the series of chemical alterations of a compound (e.g., a drug) occurring within the body, as by enzymatic activity. methods for preparing chiral drugs and drug intermediates (M. ME-ller, M. Wubbolts) SEPARATIONS Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo) Resolution of chiral drugs by preparative chromatography (E. Francotte) ANALYSIS Stereoselective chromatographic methods for drug analysis (W. Lindner) CE-MS for the quantitative analysis of chiral drugs (J. Veuthey) Spectrosopic methods for chiral drug analysis (N. Harada) Modeling of chiral drug-receptor interactions (G. Folkers) For more information visit http://www.researchandmarkets.com/reports/c43175 |
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