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Ukraine to Develop Biopharmaceuticals in Living Plants for Regional Needs in Pact With USA's Large Scale Biology Corp. and Germany's Icon Genetics AG.


Business Editors/Health & Medical Writers

KIEV, Ukraine--(BUSINESS WIRE)--Dec. 3, 2002

National Strategy for Faster, Less Expensive, Domestic

Pharmaceutical Production

In a move likely to be viewed as extremely progressive by the global pharmaceutical industry, the government of Ukraine is seeking to reduce the overall cost and development time of commercial drug manufacture by aligning the nation's future health planning with new plant-based biopharmaceutical technologies. On November 5, the Vice Prime Minister of Ukraine The Prime Minister of Ukraine (Ukrainian: Прем'єр-міністр України , Dr. Volodymyr Seminozhenko, signed an officially approved letter of intent with two foreign biotechnology companies Top 100 Biotechnology Companies
The following is a list of the top 100 biotechnology companies ranked by revenue. The first nine companies qualify for the list of the top 50 pharmaceutical companies.
 to enable domestic development of plant-derived biopharmaceuticals for eventual sale in the Commonwealth of Independent States Commonwealth of Independent States (CIS), community of independent nations established by a treaty signed at Minsk, Belarus, on Dec. 8, 1991, by the heads of state of Russia, Belarus, and Ukraine. Between Dec. 8 and Dec. . The country's cabinet of ministers has been reorganized since the signing, but the agreement has been reviewed and endorsed again before the public announcement today. Supported by the Ukraine government, Large Scale Biology Corporation (Nasdaq:LSBC LSBC Law Society of British Columbia
LSBC Large Scale Biology Corporation
LSBC Lone Star Bulldog Club
LSBC Lasalle & Bureau County Railroad Company
LSBC Lifesaver for Babies and Children (St John Ambulance, UK)
LSBC Lone Star Bit Company
) of Vacaville, California Vacaville, California is located in Solano County, California, United States, between Sacramento and San Francisco. As of the 2000 census, the city had a total population of 88,625. , USA and Icon Genetics AG of Munich, Germany would work with Ukrainian scientists to produce specific biologics (therapeutic proteins or vaccines) in living plants with the aid of LSBC and Icon proprietary technologies. In the future, participation may be expanded to include one or more Ukrainian pharmaceutical companies.

In announcing this component of the government's biopharmaceutical strategy, Dr. Seminozhenko, the Vice Prime Minister, said, "We are very worried about the high cost of therapeutic medicine and about our dependence on imports in this area. After analysis of all aspects of the problems, the Government intends to address those issues by relying on the most advanced technologies for the production of biopharmaceuticals."

Icon's transgenic plant technology would be used by Ukrainian scientists to develop the plants producing the pharmaceutical proteins, while LSBC's downstream processing Downstream processing refers to the recovery and purification of biosynthetic products, particularly pharmaceuticals, from natural sources such as animal or plant tissue or fermentation broth, including the recycling of salvageable components and the proper treatment and disposal  technology and biomanufacturing expertise would be used for commercial-scale pharmaceutical-grade production. "Icon Genetics will further strengthen our intensive collaboration with LSBC, the world leader in plant-based production of pharmaceutical proteins," said Yuri Gleba gle·ba  
n. pl. gle·bae
The fleshy, spore-bearing inner mass of a puffball.



[Latin glba, clod.
, PhD, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Icon.

For LSBC, an exclusively U.S.-based company with facilities in California, Maryland California is a census-designated place and community in St. Mary's County, Maryland, United States. The population was 9,307 at the 2000 census. California continues to grow with the spread of population out from the older adjacent community of Lexington Park and the growth in  and Kentucky, this international pharmaceutical development deal follows an announcement made in July of a plant-based vaccine development collaboration with South Africa's University of Cape Town Coordinates:
“UCT” redirects here. For other uses, see UCT (disambiguation).
 to address AIDS and cervical cancer Cervical Cancer Definition

Cervical cancer is a disease in which the cells of the cervix become abnormal and start to grow uncontrollably, forming tumors.
. "This joint effort with Ukraine further demonstrates the breadth of international opportunities in biotechnology today and the strength of LSBC in addressing global biopharmaceutical demands," said Robert L. Erwin, CEO of LSBC.

"This deal underscores growing global awareness of LSBC's unique technologies and their commercial applications," said John D. Fowler, president of LSBC. "Faster, cheaper, safe and effective drugs for human beings are our mutual goal."

About Icon Genetics AG

Icon Genetics is an integrated platform technology provider developing proprietary technologies with application to a broad range of agricultural and pharmaceutical biotechnology products. As agricultural biotechnology enters the post-genomic era, Icon is developing enabling tools and platform technologies for rapid introduction of genes into commercial varieties and for genomics applications. Icon's technology is expected to replace current imperfect first-generation products by providing integrated suites of technologies (Transgene transgene

a gene that has been incorporated into the genome of another organism.
 Operating Systems Operating systems can be categorized by technology, ownership, licensing, working state, usage, and by many other characteristics. In practice, many of these groupings may overlap. ) that will bring the speed and efficiency of crop engineering up to that of gene discovery. Corporate offices are headquartered in Munich, Germany and the company's Research divisions are located in Halle, Germany Halle, Germany may refer to:
  • Halle, Saxony-Anhalt (also called Halle an der Saale), home to University of Halle now part of Martin Luther University of Halle-Wittenberg
  • Halle, North Rhine-Westphalia (also called Halle in Westfalen)
; Freising, Germany; and Princeton, New Jersey
See also: Princeton Township, New Jersey

Princeton, New Jersey is located in Mercer County, New Jersey, United States. Princeton University has been sited in the town since 1756.
, USA. For more information about Icon Genetics AG, please visit the Company's website at www.icongenetics.com

About Large Scale Biology Corporation

Large Scale Biology uses its functional genomics Noun 1. functional genomics - the branch of genomics that determines the biological function of the genes and their products
genomics - the branch of genetics that studies organisms in terms of their genomes (their full DNA sequences)
, proteomics, and biomanufacturing technologies to develop and manufacture personalized drugs, vaccines and diagnostics for rapid identification and effective treatment of disease. Corporate offices and the Genomics Division are headquartered in Vacaville, California; the Company's Proteomics Division is located in Germantown, Maryland; and the Company's Biomanufacturing Division is located in Owensboro, Kentucky. For more information about Large Scale Biology Corporation, visit the Company's website at www.lsbc.com.

Some statements contained in this release constitute forward-looking statements that involve substantial risks and uncertainties concerning Large Scale Biology Corporation. Any statements which refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements. These forward-looking statements involve risks, uncertainties and situations that may cause our actual results, level of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements expressed or implied by these statements, including the ability of our collaborators to generate demand for products we make for them, the effectiveness of our and our collaborators' technologies to produce specific therapeutic products and/or in a cost-effective manner, any difficulties or delays in obtaining regulatory approval to test and market such products, political processes abroad concerning funding and product development commitments, and the requirement of substantial funding for us and our customers to expand commercial activities. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this release. For a further list and description of such risks and uncertainties see the reports filed by Large Scale Biology Corporation with the Securities and Exchange Commission, including our reports on Forms 10-K and 10-Q. Except as required by law, we do not undertake to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.

Note to Editors: LSBC(TM) is a trademark of Large Scale Biology Corporation.
COPYRIGHT 2002 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:4EXUR
Date:Dec 3, 2002
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