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ULTASOUND RADIOFREQUENCY USED TO TREAT HEPATIC CYSTS.


Following extensive patient studies that began in 1999, researchers at Tang Du Hospital, Fourth Military Medical University in Xian, China, have concluded that ultrasound-guided radiofrequency ablation Radiofrequency ablation (RFA)
A technique for removing a tumor by heating it with a radiofrequency current passed through a needle electrode.

Mentioned in: Liver Cancer, Prenatal Surgery
 (RFA RFA right frontoanterior (position of the fetus).
Radiofrequency ablation (RFA)
A procedure in which radiofrequency waves are used to destroy blood vessels and tissues.

Mentioned in: Prenatal Surgery
) can be an efficient and safe method for the treatment of hepatic primary cysts.

According to Dr. Du Xi-Lin, compared with other methods, ultrasound-guided RFA has many merits. "All procedures are under local anesthesia. A laparotomy laparotomy /lap·a·rot·o·my/ (-rot´ah-me) incision through the flank or, more generally, through any part of the abdominal wall.

lap·a·rot·o·my
n.
1.
 is not needed so there is minimal injury and pain," he said, adding that in most patients, one year after the procedure there was no significant recurrence. "RFA gives doctors and patients a new choice to cure hepatic cysts. It is an outstanding therapy that induces localized coagulation coagulation (kōăg'ylā`shən), the collecting into a mass of minute particles of a solid dispersed throughout a liquid (a sol), usually followed by the precipitation or  of the tumor by creating resistive resistive /re·sis·tive/ (re-zis´tiv) pertaining to or characterized by resistance.  ionic heating through the electrode." Dr. Du notes that RFA is a relatively new procedure for treatment of hepatic tumors not amenable to removal.

The Study

B-ultrasound-guided RFA [using RF-2000 System (Radio Therapeutic - USA) expandable by 10 hooks, 450 ultrasound scanning system (Hitachi - Japan)] was performed on 29 patients: 12 males, 17 females. The mean age was 47.2. Patients were diagnosed using computed tomography (CT) or magnetic resonance imaging magnetic resonance imaging (MRI), noninvasive diagnostic technique that uses nuclear magnetic resonance to produce cross-sectional images of organs and other internal body structures.  (MRI 1. (application) MRI - Magnetic Resonance Imaging.
2. MRI - Measurement Requirements and Interface.
). Tumors were single or multiple: 8 patients had a single tumor, 21 had multiple tumors. Eleven were in the left lobe; 37 on the right lobe. The longest lesions ranged from 4 cm to 21 cm. The mean diameter was 9.3 cm. Eight patients had cysts over 10 cm in diameter. Twelve patients had renal cysts with no abnormal renal function.

Patient Reaction

During the RFA procedure, patients had no significant discomfort. For those with tumors larger than 10 cm or multiple tumors, there was some sweating, local distending and fever, but no significant changes of liver function. In 3 cases, serum bilirubin Bilirubin

The predominant orange pigment of bile. It is the major metabolic breakdown product of heme, the prosthetic group of hemoglobin in red blood cells, and other chromoproteins such as myoglobin, cytochrome, and catalase.
 increase occurred but became normal after a week.

Result Assessment

For 34 cysts with <5 cm diameter, the tumors were ablated completely, with no recurrence after 3 months. For 21 cysts 5-10 cm, the decrease of tumor volume was >70% than the subsequent minification and fibering. For 8 cysts with >10 cm diameter, the decrease of tumor volume was >60%. Six cysts had minification to 80% and fibering. Two cysts had a smaller increase at one month after the RF. In subsequent checks 6 and 12 months after RFA, tumors less than 10 cm in diameter were fully ablated.

For a copy of the complete report of research findings, contact Dr. Du Xi-Lin at dxlin@fmmu.edu.cn.
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Publication:Worldwide Biotech
Date:Oct 1, 2006
Words:410
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