Two genes for Joseph disease.Two genes, located on different chromosomes Chromosomes Spaghetti-like structures located within the nucleus (or central portion) of each cell. Chromosomes contain the genetic information necessary to direct the development and functioning of all cells and systems in the body. , are associated with Joseph disease, a fatal genetic disorder in which loss of specific brain cell leads to paralysis paralysis or palsy (pôl`zē), complete loss or impairment of the ability to use voluntary muscles, usually as the result of a disorder of the nervous system. . The first gene, found on human chromosome 1, appears to cause the disease, which is inherited inherited received by inheritance. inherited achondroplastic dwarfism see achondroplastic dwarfism. inherited combined immunodeficiency see combined immune deficiency syndrome (disease). as a dominant disorder. A second gene, called the modifier gene Noun 1. modifier gene - a gene that modifies the effect produced by another gene modifier cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as , reduces the severity of, or even eliminates, Joseph disease in persons who are expected to develop the disease. Abraham I. Grossman of the University of Texas Health Sciences Center at Dallas and his colleagues have located the modifier gene on human chromosome 2. |
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