Two APL trials provide mixed results.Two clinical trials testing altered peptide ligands (APLs) in relapsing-remitting MS were halted ahead of schedule, because of side effects Side effects Effects of a proposed project on other parts of the firm. . In both studies, the APLs produced allergic reactions allergic reaction n. A local or generalized reaction of an organism to internal or external contact with a specific allergen to which the organism has been previously sensitized. , and in one they may have actually triggered exacerbations (or attacks of MS symptoms). The disappointing findings were reported in the October 2000 issue of Nature Medicine. APL (A Programming Language) A high-level mathematical programming language noted for its brevity and matrix generation capabilities. Developed by Kenneth Iverson in the mid-1960s, it runs on micros to mainframes and is often used to develop mathematical models. therapy was thought to be of value because of the possibility that it could change "bad" inflammatory immune responses into "good" anti-inflammatory responses. Both studies confirmed that these bioengineered immune system immune system Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. triggers do induce an immune response in MS. In one study, the APLs seemed to bring about the responses investigators had hoped for. In the other, the response did not appear to have been changed. APL therapy may still have potential as a possible treatment for MS. However, further research is needed to determine how APLs affect immune function Immune function The state in which the body recognizes foreign materials and is able to neutralize them before they can do any harm. Mentioned in: Herbalism, Traditional Chinese, Stress Reduction , and to clarify whether some individuals may be more responsive to them than others. |
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