Treatment for resistant depression.
Some patients with resistant depression respond to orbitomedial frontal surgical lesions with significant improvement or complete remission, but there have been no reliable indicators of success--and research should address this gap, reported Dr. Per-minder S. Sachdev and Jagdeep Sachdev of the Neuropsychiatric Institute, Prince of Wales Hospital
Seventy-six consecutive patients at the Prince Henry Hospital were treated with bilateral stereotactic stereotactic /ster·eo·tac·tic/ (-tak´tik)
1. characterized by precise positioning in space; said especially of discrete areas of the brain that control specific functions.
2. pertaining to stereotactic surgery. orbitomedial lesions for resistant severe depression between 1973 and 1995. After these patients were followed for a mean of 14 years, nearly 32% (24) of the subjects were dead, with 6 having committed suicide (J. Neuropsychiatry neuropsychiatry /neu·ro·psy·chi·a·try/ (noor?o-si-ki´ah-tre) the combined specialties of neurology and psychiatry.
n. Clin. Neurosci. 2005;17:478-85).
Of the 52 surviving patients, whose mean age was 63 years, 23 underwent in-depth interviews, and lesions were verified in 18 of them by MRI 1. (application) MRI - Magnetic Resonance Imaging.
2. MRI - Measurement Requirements and Interface. . With a 6-point global outcome rating scale, rated by consensus between two independent psychiatrists, 23% of the subjects were judged to be in remission, and half were judged to be in remission, and half were judged significantly improved, the investigators reported.
The improvement was noted within days or weeks or the surgery, although full recovery could take many months, according to the investigators.
Cognitive impairment was mild; other adverse effects included epilepsy in two subjects, marked personality change in one subject, weight gain in two subjects, and mild personality change in five subjects, the investigators said.