Transgene Presents Positive Phase I/II Data on Its Adeno-Interferon Gamma Product in Cutaneous Lymphoma at the American Society of Gene Therapy Meeting.Transgene (Nouveau Marche Nouveau Marche
An equity market unit of the Paris Bourse that deals solely in innovative, high-growth companies. : TRANSGENE or 6274 - Nasdaq: TRGNY) announced today further encouraging results from its Phase I/II clinical trial of its immunotherapy product candidate Ad-IFN gamma in patients with primary cutaneous cutaneous /cu·ta·ne·ous/ (ku-ta´ne-us) pertaining to the skin.
Of, relating to, or affecting the skin.
Pertaining to the skin. lymphoma. The data from the on-going clinical trial were presented on Saturday, June 7 at the cancer clinical trials session of the 6th Annual Meeting of the American Society of Gene Therapy in Washington D.C., by Dr. Mirjana Urosevic, M.D., of the Dermatology Unit at the University Hospital in Zurich, Switzerland (Pr. R. Dummer, principal investigator Noun 1. principal investigator - the scientist in charge of an experiment or research project
scientist - a person with advanced knowledge of one or more sciences ).
The study was initiated as a standard dose-escalation Phase I clinical trial Noun 1. phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained
phase I in nine patients with advanced primary cutaneous T-cell lymphomas or multilesional cutaneous B-cell lymphomas and has been extended as a Phase I/II trial targeting a larger patient population in different cutaneous lymphomas subtypes, with the possibility for multi-tumor injections.
"We see these results as a confirmation of the potential for our adenoviral vector for the delivery of cytokines," said Jean-Francois Carmier, Chief Executive Officer of Transgene. "The use of cytokines as a cancer treatment has suffered serious limitations due to their toxicity when administered systemically and significant efforts have been put into overcoming these limitations. We believe that with its ability to express the cytokine Cytokine
Any of a group of soluble proteins that are released by a cell to send messages which are delivered to the same cell (autocrine), an adjacent cell (paracrine), or a distant cell (endocrine). locally and to generate a therapeutic effect at distant lesions, without any serious side effects Side effects
Effects of a proposed project on other parts of the firm. , our adenoviral vector shows promise as an important cytokine delivery system."
The results from 13 patients have been analysed to date. The analyzed results showed:
- Ad-IFN gamma was well tolerated up to the highest dose level (3.10(11) viral particules). Only two transient Serious Adverse Events (diarrhea and nausea/vomiting) were reported. All other adverse events were mild or moderate with injection site reactions, transient fever and headache as the most commonly observed adverse events. - Clinical responses observed both locally (5 complete and 2 partial responses out of 11 evaluable patients ) and at distant sites (3 complete responses out of 9 evaluable patients), leading to an overall response rate of 60 percent ( 4 complete and 2 partial responses out of 10 evaluable patients). - Gene transfer and expression of the IFN gamma gene on both protein and messenger RNA levels. - Pronounced changes in infiltrate histological pattern, with signs of vasculitis and increases in cytotoxic immune effector cells. - An up-regulation of genes involved in immune responses by gene expression profiling of tissue samples, as well as of peripheral blood mononuclear cells, performed before and after treatment.
"I am delighted by the promising responses observed in this trial," stated Patrick Squiban, M.D., Transgene Vice-President for Medical and Regulatory Affairs. "These data are very encouraging for supporting further development of the product as well as for our cytokine gene-based immunotherapy projects."
About Cutaneous Lymphoma:
Primary cutaneous lymphoma (PCL (Printer Command Language) The page description language for HP LaserJet printers. It has become a de facto standard used in many printers and typesetters. PCL Level 5, introduced with the LaserJet III in 1990, also supports Compugraphic's Intellifont scalable fonts. ) encompasses a spectrum of diseases defined by a malignant clonal proliferation of cutaneous lymphocytes. With a prevalence of 6 patients per 100,000 inhabitants in European countries, PCL ranks second to melanoma as the most frequent dermatologic life-threatening diagnoses. PCL is characterized by its heterogeneity of clinical presentations, prognostic and therapeutic options.
* Cutaneous T-cell lymphoma (CTCL) is a lymphoproliferative disorder of epidermotropic, neoplastic T-cells with a wide range of clinical manifestations: mycosis fungoides, Sezary syndrome, pleomorphic small/intermediate-cell CTCL and large-cell CTCL. * Cutaneous B-cell lymphomas (CBCL) is a rare group of lymphoproliferative disorders, a distinct form of non-Hodgkin's lymphoma (NHL), the most common forms being follicular lymphoma, immunocytoma (including marginal zone B-cell lymphoma), and large-cell B-cell lymphoma of the leg.
Due to their heterogeneity, there are no universally applicable guidelines available for the treatment of cutaneous lymphomas. In contrast with the excellent chance of cure at early stage, advanced disease is marked by burdensome, debilitating de·bil·i·tat·ing
Causing a loss of strength or energy.
Weakening, or reducing the strength of.
Mentioned in: Stress Reduction tumors and a fatal outcome fatal outcome,
n a consequence that results in death. The course of a disease that results in the death of the patient. despite the use of very aggressive and often poorly-tolerated therapy.
About Ad-IFN gamma:
Ad-IFN gamma uses an improved version of Transgene's adenovirus adenovirus
Any of a group of spheroidal viruses, made up of DNA wrapped in a protein coat, that cause sore throat and fever in humans, hepatitis in dogs, and several diseases in fowl, mice, cattle, pigs, and monkeys. vector carrying the Interferon gamma interferon gamma IFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, gene. Results from pre-clinical work demonstrated good cytokine expression, both in continuous cell lines and in primary human tumor models. Ad-IFN gamma has been designed for intratumoral administration in the treatment of various cancers, potentially in conjunction with other forms of treatments.
Transgene, based in Strasbourg, France, is a biopharmaceutical company dedicated to the discovery and development of therapeutic vaccines, gene therapy products, and delivery technologies for the treatment of diseases for which there is no cure or adequate treatment at present, with a focus on the treatment of cancer. Transgene has five products in clinical development, two of which are in Phase II clinical trials and three of which have completed Phase I clinical trials. Transgene's proprietary vector technology platform consists of multiple vector families with an emphasis on adenovirus, poxvirus poxvirus
Any of a group of viruses responsible for a wide range of pox diseases in humans and other animals. Poxvirus was the cause of smallpox. (Human chickenpox is caused by varicella-zoster virus. and non-viral vectors.
This press release contains forward-looking statements, including statements regarding the efficiency and safety of and potential market for Transgene's product candidates and prospects. Statements that are not historical facts are based on Transgene's current expectations, beliefs, estimates, forecasts and assumptions. The statements contained in this release are not guarantees of future performance and involve certain risks, uncertainties and assumptions which are difficult to predict. Accordingly, actual outcomes and results may differ materially from what is expressed in those forward-looking statements. Important factors which may affect Transgene's future operating results include the following: Transgene's product candidates may not demonstrate therapeutic efficacy after initial promising results, Transgene may be unable to obtain regulatory approval for its product candidates, Transgene may be unable to conduct its clinical trials as quickly as it has predicted, Transgene may not have sufficient resources to complete the research and commercialization of any of its product candidates, competitors may develop technologies or products superior to Transgene's technologies or products, and other important factors described in Transgene's Annual Report on Form 20-F for the year ended December 31, 2001 filed with the U.S. Securities and Exchange Commission, including those factors described in the section entitled "Risk Factors."
CONTACT: Patrick Squiban, M.D., V.P., Medical & Regulatory Affairs of Transgene, +33-3-88-27-92-08; Julio Cantre of Cohn & Wolfe, +1-212-798-9779; Marie-Carole de Groc of Euro RSCG Omnium, +33-1-58-47-95-07, both of Transgene