Tohoku University Sheds Light on Roles of Pathogen Recognition Molecule in Natural Immunity.Tokyo, Japan, June 13, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - Tohoku University's Graduate School of Pharmaceutical Sciences has elucidated the roles of peptidoglycan peptidoglycan /pep·ti·do·gly·can/ (pep?ti-do-gli´kan) a glycan (polysaccharide) attached to short cross-linked peptides; found in bacterial cell walls. pep·ti·do·gly·can n. recognition protein (PGRP (Peer Gatekeeper Routing Protocol) An H.323 IP telephony protocol that is used to exchange call routing information between gatekeepers. See H.323. )-LE in natural immunity in collaboration with the University of Massachusetts Medical School UMMS is ranked fourth in primary care education among the nation’s 125 medical schools in the 2006 U.S.News & World Report annual guide, “America’s Best Graduate Schools”. UMMS is also a major center for research. . The two universities have discovered that PGRP-LE is involved in recognizing pathogen components on the cell surface as well as in the cell. Specifically, on the cell surface, PGRP-LE exerts such effects as a co-receptor of PGRP-LC, one of the PGRP family members. In addition, the universities have found that PGRP-LC and PGRP-LE have a similar structure called RHIM-like motif. The RHIM-like motif plays a role in inducing a natural immune response. Tohoku University has commented that these findings will shed light on immune defense mechanisms. Details of the joint research are available in the online issue of Nature Immunology, which was published on June 11, under the title "PGRP-LC and PGRP-LE play essential yet distinct roles in the drosophila Drosophila: see fruit fly. drosophila Any member of about 1,000 species in the dipteran genus Drosophila, commonly known as fruit flies but also called vinegar flies. Some species, particularly D. immune response to monomeric DAP-type peptidoglycan". Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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