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Tm Bioscience and MetriGenix Announce Launch of Universal Array.


Business Editors/Health & Medical Writers

BIOWIRE2K

TORONTO & GAITHERSBURG, Md.--(BUSINESS WIRE)--Dec. 17, 2002

Tm Bioscience Corporation (TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
 Venture: TMC TMC Technology Marketing Corporation (Norwalk, Connecticut)
TMC Texas Medical Center (Houston, TX)
TMC Traffic Message Channel
TMC The Movie Channel
TMC Traffic Management Center
) and MetriGenix, Inc. (Gaithersburg, Maryland, U.S.) announced today the launch of the Tm100 Universal Array on MetriGenix's proprietary 4D Assay System(TM).

Today's launch of the Tm100 Universal Array meets a goal of the licensing agreement between the two companies announced earlier this year of launching the Tm100 Universal Array by year-end.

The Universal Array technology is an improvement over standard DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 biochips/microarrays, providing increased accuracy, reliability and flexibility, all at lower cost. Traditional biochips require that each DNA assay be designed and optimized in a single process, with cost savings achieved only through mass production of the final biochip biochip

Small-scale device, analogous to an integrated circuit, constructed of or used to analyze organic molecules associated with living organisms. One type of theoretical biochip is a small device constructed of large organic molecules, such as proteins, and capable of
 product.

With the Universal Array, an open platform array has been created, optimized and manufactured for DNA assay applications. Customers now have the freedom to design, modify and put their DNA assay application onto the Universal Array platform.

The MetriGenix 4D Assay System(TM) utilizes a patented flow-through design that optimizes the surface area-to-volume ratio to provide superior performance in comparison to conventional microarrays. The 4D Assay System(TM) has shorter hybridization hybridization /hy·brid·iza·tion/ (hi?brid-i-za´shun)
1. crossbreeding; the act or process of producing hybrids.

2. molecular hybridization

3.
 times, provides larger binding/signal capacity, and is more readily automated than flat biochips.

The result is a faster, more robust platform that requires smaller amounts of sample and reagents.

"The specificity of the Tm100 Universal Array sequences will accelerate our efforts to produce flexible, economical arrays that can be optimized for gene sequences," said Dr. Andrew O'Beirne, President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of MetriGenix. "We believe that the combination of the Universal Array and our high-performance 4D Assay System(TM) can provide the robust platform that life science researchers have been seeking for years. The Universal Array on the MetriGenix platform should enable researchers to combine sets of 96 specific DNA tests into a single assay."

"The availability of the Tm 100 Universal Array on MetriGenix's 4D Assay System(TM) will allow life science researchers to develop a new generation of highly accurate, high-throughput and low cost genetic tests," said Greg Hines, President and CEO of Tm Bioscience. "The speed with which this product was brought to market demonstrates the robustness and flexibility of the 4D Assay System(TM)."

About Tm Bioscience - Putting the Human Genome The human genome is the genome of Homo sapiens, which is composed of 24 distinct pairs of chromosomes (22 autosomal + X + Y) with a total of approximately 3 billion DNA base pairs containing an estimated 20,000–25,000 genes.  to Work(TM)

Tm Bioscience is a DNA-based diagnostics company developing a suite of genetic tests. Tm Bioscience's product pipeline includes tests for genetic mutations related to hematology, cystic fibrosis cystic fibrosis (sĭs`tĭk fībrō`sĭs), inherited disorder of the exocrine glands (see gland), affecting children and young people; median survival is 25 years in females and 30 years in males. , toxicology and other debilitating de·bil·i·tat·ing
adj.
Causing a loss of strength or energy.


Debilitating
Weakening, or reducing the strength of.

Mentioned in: Stress Reduction
 genetic disorders The following is a list of genetic disorders and their origins. Beside most disorders is a code that indicates the type of fertilization and the chromosome involved.
  • P - Point mutation, or any insertion/deletion entirely inside one gene
. Tm Bioscience has also developed internal expertise in the development and manufacturing of DNA based diagnostics.

Tm Bioscience is an ideal partner for companies, academics or clinical labs with novel gene content who want to capture near term value through the development of marketable tests. Tm Bioscience is located in Toronto, Ontario. Additional information about Tm Bioscience can be found at www.tmbioscience.com.

About MetriGenix

MetriGenix, Inc. is a biotechnology company focused on developing a biochip platform based on the Flow-thru Chip(TM) technology. The Flow-thru Chip(TM) technology is a scaleable, high-performance microarray platform with a microchannel structure that results in a much larger surface area-to-volume ratio than is attained with flat surface platforms.

The unique structure of the Flow-thru Chip(TM) technology yields performance enhancements in capacity, kinetics, and uniformity for biological sensing applications. MetriGenix has combined the Flow-thru Chip(TM) technology, which includes custom and branded chips, and its associated instrumentation, into a complete biomolecular analysis solution--the 4D Assay System(TM).

The 4D Assay System(TM) has been developed for pharmaceutical and biotechnology companies for use in biological discovery programs, pharmaceutical screening, genetic diagnostics and individualized in·di·vid·u·al·ize  
tr.v. in·di·vid·u·al·ized, in·di·vid·u·al·iz·ing, in·di·vid·u·al·iz·es
1. To give individuality to.

2. To consider or treat individually; particularize.

3.
 disease management.

For additional information about MetriGenix, the Flow-thru Chip(TM), the 4D Assay System(TM), and the Universal Array, please call 301/987-1716 or visit the Company Web site at www.metrigenix.com.

The TSX Venture Exchange TSX Venture Exchange

Originally called the Canadian Venture Exchange (CDNX), this was a result of the merger of the Vancouver and Alberta stock exchanges. The goal of TSX Venture Exchange is to provide venture companies with effective access to capital while protecting investors.
 has not reviewed and does not accept responsibility for the adequacy or accuracy of this release.
COPYRIGHT 2002 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1CANA
Date:Dec 17, 2002
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