This Book Addresses all the Current, Up-to-Date Developments in Hepatotoxicity From Genomics to In Vitro and In Vivo Models.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c82971) has announced the addition of "Hepatotoxicity hepatotoxicity (hepˑ·  ·tō·t : From Genomics to In Vitro and In Vivo
Models" to their offering.
This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action. This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science. Contributors. Preface. Acknowledgements. SECTION 1: MODELS FOR HEPATOTOXICITY TESTING. 1 Current in vitro Models to Study Drug-Induced Liver Injury (Julio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O'Brien and Stephen C. Storm). 2 Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery (Ikuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa). 3 Use of Hepatocytes for Characterizing a Candidate Drug's Metabolism and Drug Interaction Potential (Srikanth C. Nallani, John M. Strong and Shiew Mei Huang). 4 Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety (Albert P. Li). 5 Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity (Saura C. Sahu). 6 Some Experimental Models of Liver Damage (Pablo Muriel). SECTION 2: HEPATOCYTE hepatocyte /hep·a·to·cyte/ (hep´ah-to-sit?) a hepatic cell. hep·a·to·cyte n. A parenchymal liver cell. Hepatocyte A liver cell. CULTURES. 7 Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities (Gregor Tuschl, Jens Hrach, Philip G. Hewitt and Stefan O. Mueller). SECTION 3: BIOMARKERS OF HEPATOTOXICITY. 8 Biomarkers of Mycotoxin mycotoxin Toxin produced by a fungus. Numerous and varied, mycotoxins can cause hallucinations, skin inflammation, liver damage, hemorrhages, miscarriage, convulsions, neurological disturbances, and/or death in livestock and humans. Exposure in Liver Toxicity (Angela J. Harris). SECTION 4: MECHANISMS OF HEPATOTOXICITY. 9 Mechanisms of Toxic Liver Injury (Nora Anderson and Jurgen Borlak). 10 A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity (Yasuhiro Ishihara and Norio Shimamoto). 11 A Mechanistic View of Troglitazone troglitazone a thiazolidinedione compound that enhances peripheral insulin resistance in the management of diabetes mellitus. Hepatotoxicity (Rawiwan Maniratanachote and Tsuyoshi Yokoi). 12 Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis (James E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip). 13 Sinusoidal sinusoidal /si·nus·oi·dal/ (si?nu-soi´dal) 1. located in a sinusoid or affecting the circulation in the region of a sinusoid. 2. shaped like or pertaining to a sine wave. Cells in Liver Injury and Repair (Carol R. Gardner and Debra L. Laskin). 14 Cytokines Cytokines Chemicals made by the cells that act on other cells to stimulate or inhibit their function. Cytokines that stimulate growth are called "growth factors. in Liver Diseases (Pablo Muriel). 15 Bile Acids as Modulators of Apoptosis (Rui E. Castro, Susana Sola, Clifford J. Steer and Cecilia M.P. Rodrigues). 16 Drug-Induced Intrahepatic Cholestasis Cholestasis Definition Cholestasis is a condition caused by rapidly developing (acute) or long-term (chronic) interruption in the excretion of bile (a digestive fluid that helps the body process fat). by Interaction with the Hepatic Bile Salt Export Pump (BSEP BSEP Bile Salt Export Pump BSEP Basic Skills Education Program BSEP Black Sea Environmental Program ) (Christoph Funk, Johannes Noe, Renee Portmann, Ruben Alvarez-Sanchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze). SECTION 5: GENOMICS OF HEPATOTOXICITY. 17 Application of Toxicogenomics in Predicting Hepatotoxicity - Potentials and Challenges (Wen Lin, Guoxiang Shen Shen, in the Bible, place, perhaps close to Bethel, near which Samuel set up the stone Ebenezer. , Tin Oo Khor and Ah-Ng Tony Kong). 18 Genomic Profiling of Liver Injury (Kevin Gerrish and David E. Malarkey ma·lar·key also ma·lar·ky n. Slang Exaggerated or foolish talk, usually intended to deceive: "snookered by a lot of malarkey" New Republic. ). 19 Use of DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. Arrays in Understanding Hepatic Test Systems (Angela J. Harris and Daniel A. Casciano). 20 Prediction of Hepatotoxicity Based on the Toxicogenomics Database (Tetsuro Urushidani). 21 Relationship between N-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity (Yasuo Shimizu, Kunio Dobashi and Masatomo Mori). SECTION 6: GENDER DIFFERENCES IN HEPATOTOXICITY. 22 Human and Animal-Based Differences in Hepatic Xenobiotic xen·o·bi·ot·ic adj. Foreign to the body or to living organisms. Used of chemical compounds. n. A xenobiotic chemical. xenobiotic any substance, harmful or not, that is foreign to the animal's biological system. Metabolism and Toxicity (Peter J. O'Brien, Katie Chan and Raymond J. Poon poon n. Any of several trees of the genus Calophyllum, of southern Asia, having light hard wood used for masts and spars. [Sinhalese p ). SECTION 7: HEPATOTOXICITY AND HEPATOCARCINOGENICITY. 23 Hepatotoxicity in Oncology Drug Development (Wei Chen, Kenneth Hastings and John K. Leighton). 24 The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology (Daniel A. Casciano). SECTION 8: HEPATOTOXICITY AND BOTANICAL SUPPLEMENTS. 25 Botanical Supplements and Hepatotoxicity (Shabana Khan, Ikhlas Khan and Larry Walker). SECTION 9: RISK ANALYSIS OF HEPATOTOXINS. 26 Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants (Kannan Krishnan). Index. For more information visit http://www.researchandmarkets.com/reports/c82971. |
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