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ThermoGenesis granted patent for cryopreservation system.


ThermoGenesis thermogenesis /ther·mo·gen·e·sis/ (-jen´e-sis) the production of heat, especially within the animal body.thermogenet´icthermogen´ic

ther·mo·gen·e·sis
n.
 Corporation (Rancho Cordova, CA) announced that the European Patent Office has granted a patent entitled "Method & Apparatus for Cryogenic Storage of Thermolabile thermolabile /ther·mo·la·bile/ (-la´bil) easily affected by heat.

ther·mo·la·bile
adj.
Subject to destruction, decomposition, or great change by moderate heating.
 Products" which contains broad claims covering the technology used in the BioArchive System, an automated cryogenic device used by cord blood stem cell banks in most of the industrialized in·dus·tri·al·ize  
v. in·dus·tri·al·ized, in·dus·tri·al·iz·ing, in·dus·tri·al·iz·es

v.tr.
1. To develop industry in (a country or society, for example).

2.
 countries to obtain precision cryogenic freezing and robotic storage and retrieval of cord blood stem cell units for transplant.

"ThermoGenesis continues to broaden its intellectual property portfolio behind its unique, advanced cord blood stem cell processing and storage technology that ensures the proper preservation of stem cells so they are usable in life saving treatments," said Philip Coelho, Chairman and Chief Executive Officer of ThermoGenesis Corp. "The BioArchive System has become the preferred platform at more than 80 cord blood stem cell banks in 29 countries and we have built a formidable IP estate with ten issued United States, Japanese and European patents covering our BioArchive technology."

The BioArchive System cryopreserves, archives and retrieves samples within liquid nitrogen without exposing the samples to detrimental Transient Warming Events, which can reduce cell viability. The BioArchive System is a computer-driven robotic system to allow users to cryopreserve cry·o·pre·serve  
tr.v. cry·o·pre·served, cry·o·pre·serv·ing, cry·o·pre·serves
To preserve (cells or tissue, for example) by freezing at very low temperatures.
 and archive up to 3,623 units of blood components in -196 degrees C liquid nitrogen.

GE Healthcare is the non-exclusive global distribution partner for the BioArchive System as well as the exclusive distribution partner for ThermoGenesis' AutoXpress System, the first fully closed, automated cord blood stem cell processing system that simplifies the traditional, labor-intensive manual process that often requires an expensive 'clean room'.

Cord blood stem cell banks use the AutoXpress System to separate stem cells from umbilical cord blood umbilical cord blood Transplantation A source of primitive and stem cells that can be used to reconstitute BM destroyed by aplastic anemia or by RT or chemotherapy for CA, lymphoproliferative malignancies. See Bone marrow transplantation, Stem cell therapy.  and then utilize the BioArchive System to cryogenically freeze and store the stem cells. These cells can then be effectively used for patients who require stem cell reconstitution in the treatment of diseases like acute leukemia, lymphoma and numerous genetic diseases.

Unlike embryonic stem cells that have only been used in clinical trial research, cord blood stem cells cord blood stem cells Umbilical cord blood Hematology A therapeutic 'agent' containing concentrated hematopoietic stem cells for Pts with BM depleted–'wiped out' by disease; they are transfused into HLA-identical siblings and used to reconstitute the BM of  have already been used more than 10,000 times to treat patients with life threatening diseases including leukemia, lymphoma and more than 60 different genetic disorders. Further, recent peer-reviewed scientific articles indicate stem cells residing in cord blood can also differentiate into other tissues of the body including the brain, bone, cartilage, and muscle, indicating potential broader application of cord blood stem cells in future clinical use.

ThermoGenesis is a leader in developing and manufacturing automated blood processing systems and disposables that enable the manufacture, preservation and delivery of cell and tissue therapy products.

-- The BioArchive System, an automated cryogenic device, is used by cord blood stem cell banks in more than 25 countries for cryopreserving and archiving cord blood stem cell units for transplant. GE Healthcare is the non-exclusive global distribution partner for the BioArchive System.

-- The AutoXpress System, is a newly developed semi-automated device and companion sterile closed blood processing disposable, to harvest stem cells from cord blood. GE Healthcare is the exclusive global distribution partner for the AXP The brand name Digital gave to its first family of Alpha-based computers. In 1998, Digital was acquired by Compaq. See Alpha.  AutoXpress System.

-- The CryoSeal FS System, an automated device and companion sterile blood processing disposable, is used to prepare fibrin sealants from plasma in about an hour. Enrollment in a 150-patient United States pivotal clinical trial has been completed and a PMA PMA (papillary-marginal-attached),
n a system of epidemiologic scoring of periodontal disease devised by Schour and Massler in which the symbols denote the areas involved in gingival inflammation.

PMA Progressive muscular atrophy
 is being reviewed by the FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
. The CryoSeal FS System has received the CE-Mark. From a marketing perspective, the CE Mark is the European equivalent to an FDA approval, in that it allows sales of the product throughout the European community.

-- The Thrombin thrombin: see blood clotting.  Processing Device is a sterile blood processing disposable that prepares activated thrombin from a small aliquot aliquot (al-ee-kwoh) adj. a definite fractional share, usually applied when dividing and distributing a dead person's estate or trust assets. (See: share)  of plasma in less than 30 minutes.

Thermogenesis Corporation

www.thermogenesis.com
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No portion of this article can be reproduced without the express written permission from the copyright holder.
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Publication:BIOTECH Patent News
Date:Oct 1, 2006
Words:620
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