The influence of large-scale airborne particle decline and traffic-related exposure on children's lung function.Between 1991 and 2000, ambient Surrounding. For example, ambient temperature and humidity are atmospheric conditions that exist at the moment. See ambient lighting. air pollution in East Germany East Germany: see Germany. changed to resemble West German pollution levels: The concentration of total suspended particles (TSPs) decreased on a broad scale while traffic increased. During that time, we analyzed an·a·lyze tr.v. an·a·lyzed, an·a·lyz·ing, an·a·lyz·es 1. To examine methodically by separating into parts and studying their interrelations. 2. Chemistry To make a chemical analysis of. 3. total lung capacity total lung capacity n. Abbr. TLC The volume of gas that is contained in the lungs at the end of maximal inspiration. total lung capacity, n the maximum volume of air the lungs can hold. (TLC TLC total lung capacity; thin-layer chromatography. TLC abbr. 1. thin-layer chromatography 2. ) and airway resistance airway resistance Lung physiology A measure of the resistance–in cm H2O to the flow–in L/min of air in upper airways, the result of natural recoil–resiliency of anatomic structures–oro- and nasopharynx, larynx, and nonrespiratory ([R.sub.aw]) of East and West German children. We tested children 5-7 years of age (n = 2,574) with cooperatiun-independent body plethysmography The introduction to this article provides insufficient context for those unfamiliar with the subject matter. Please help [ improve the introduction] to meet Wikipedia's layout standards. You can discuss the issue on the talk page. in repeated cross sections. We used random-effect models to determine the mutually adjusted association between lung function and short-term and chronic particle exposure and its interaction with living near a busy road. Annual averages of TSPs declined from 77 to 44 [micro]g/[m.sup.3]; averages on the day of investigation declined from 133 to 30 [micro]g/[m.sup.3]. Differences in lung function between East and West German children vanished during the investigation time. The association of TSPs with [R.sub.aw] and TLC was stronger in children living > 50 m away from busy roads. East German children from this group had an Raw 2.5% higher [95% confidence interval confidence interval, n a statistical device used to determine the range within which an acceptable datum would fall. Confidence intervals are usually expressed in percentages, typically 95% or 99%. (CI), 0.0-5.1%] per 40-pg/m3 increase of daily TSP TSP - travelling salesman problem averages. TLC decreased by 6.2% (95% CI, 0.04-11.6%) per 40-[micro]g/[m.sup.3] increase in annual mean TSPs, and this effect was equally pronounced in East and West Germany West Germany: see Germany. . TSP exposure decreased on a broad scale between 1991 and 2000. Lower concentrations of TSPs were associated with better measures of lung function in 6-year-old children. For children riving near busy roads, this effect was diminished. Key words: air pollution, children, German reunification This article is about the 1990 German reunification. For the 1871 German Empire, see Unification of Germany. German reunification (German: Deutsche Wiedervereinigung , lung function, particulate matter particulate matter n. Abbr. PM Material suspended in the air in the form of minute solid particles or liquid droplets, especially when considered as an atmospheric pollutant. Noun 1. , repeated cross sections, traffic. (2006). doi:10.1289/ehp.8180 available via http://dx.doi.org/[Online 20 September 2005] ********** Before the reunification re·u·ni·fy tr.v. re·u·ni·fied, re·u·ni·fy·ing, re·u·ni·fies To cause (a group, party, state, or sect) to become unified again after being divided. of Germany in 1989, outdoor mass concentration of total suspended particles (TSPs) was higher in East Germany than in West Germany because of emissions from industry and domestic sources, but traffic-related air pollution was higher in West Germany than in East Germany. During the first years after reunification, TSP levels declined considerably in East Germany and reached the West German levels, but emissions from traffic increased. The size distribution of airborne particles exhibited a shift toward finer particles (Ebelt et al. 2001; Kreyling et al. 2003). The effect of this changing pattern on lung function in 6-year-old children has not been investigated so far. To date, evidence for an effect of ambient air pollution exposure on lung function in children comes from studies investigating school children at least 8 years of age. All these studies used spirometric measures [forced vital expiratory ex·pi·ra·to·ry adj. Of, relating to, or involving the expiration of air from the lungs. expiratory relating to or employed in the expiration of air from the lungs. capacity (FVC FVC forced vital capacity. FVC abbr. forced vital capacity FVC, n See forced vital capacity. FVC forced vital capacity. ), forced expiratory volume forced expiratory volume n. Abbr. FEV The maximum volume of air that can be expired from the lungs in a specific time interval when starting from maximum inspiration. in 1 sec (FE[V.sub.1]), and peak expiratory flow peak expiratory flow n. The maximum flow of air at the outset of forced expiration, which is reduced in proportion to the severity of airway obstruction, as in asthma. (PEF PEF peak expiratory flow. )], which depends on cooperation of the children and thus is more difficult to manage in children of a younger age. Most studies, with one exception (Dockery et al. 1989), found an adverse association with chronic exposure to air pollution (Islam and Schlipkoter 1993; Peters et al. 1999; Pope and Arden 2000; Schindl 1993; Schwartz 1989). Elevated levels of urban ambient air pollution were found to retard development of children's lung function (He et al. 1993; Gauderman et al. 2000, 2002, 2004). Decline of long-term exposure to air pollution was associated with an increase of FVC (Frye et al. 2003). Lung function of children has been associated with traffic-related exposure in a number of epidemiologic studies epidemiologic study A study that compares 2 groups of people who are alike except for one factor, such as exposure to a chemical or the presence of a health effect; the investigators try to determine if any factor is associated with the health effect (Brunekreef et al. 1997; Fritz fritz n. Informal A condition in which something does not work properly: Our television is on the fritz. [Perhaps from German Fritz and Herbarth 2001; Wjst et al. 1993). Acute effects were mostly investigated independently from long-term effects. Short-term ambient exposure of children to fine particles Fine particles are an air pollutant mainly produced by cars running on diesel. Other sources are the combustion of fossil fuels in power plants and various industrial processes. (Hoek et al. 1998) or winter air pollution (Peacock peacock or peafowl, large bird of the genus Pavo, in the pheasant family, native to E Asia. There are two main species, the common (Pavo cristatus), and the Javanese (P. et al. 2003) resulted in PEF decrement To subtract a number from another number. Decrementing a counter means to subtract 1 or some other number from its current value. and small but statistically significant decline in forced expiratory volume in 0.75 sec and FE[V.sub.1] (Pope and Arden 2000). Adults also showed decreased forced expiratory volumes and flows (Schindler et al. 2001). In this study we added four new aspects to the body of evidence concerning the association between outdoor air pollution and lung function in children. First, in 6-year-old children, younger than in most previous studies, we investigated the association of lung function with TSPs and traffic-related pollution. Young children are a susceptible subgroup sub·group n. 1. A distinct group within a group; a subdivision of a group. 2. A subordinate group. 3. Mathematics A group that is a subset of a group. tr.v. for air pollution health effects (Kim 2004; Mathieu-Nolf 2002). We targeted 6-year-old children because the adolescent spurt spurt Vox populi A surge or abrupt ↑ in the size or speed of a thing. See Fat spurt, Growth spurt. has not started yet (Wang et al. 1993a, 1993b). Because of the young age of the subjects, we used measures of lung function that require little collaboration [airway resistance ([R.sub.aw]) and total lung capacity (TLC)]. Second, we simultaneously considered the influence of short-term and chronic TSP exposure on lung function. [R.sub.aw] reacts rapidly to short-term exposure by means of bronchoconstriction and/or hypersecretion and might therefore preferentially pref·er·en·tial adj. 1. Of, relating to, or giving advantage or preference: preferential treatment. 2. show acute effects, whereas TLC changes slowly and might show long-term effects. Third, we compared effects of TSP exposure on lung function in children from East and West Germany, thereby adjusting for many additional changes in lifestyle that occurred between 1991 and 1997 in East Germany after reunification. Fourth, the effects of traffic-related exposure were included in our study. We expected the effects of living near a busy road to increase between 1991 and 1997 in East Germany, thereby diminishing the effects of the broad-scale decrease in TSPs. Materials and Methods Study subjects and sites. This study is part of a large study in East and West Germany investigating the health effects of the changing environmental and socioeconomic so·ci·o·ec·o·nom·ic adj. Of or involving both social and economic factors. socioeconomic Adjective of or involving economic and social factors Adj. 1. conditions after reunification in school beginners (6 years of age) between 1991 and 2000 (Kreimer et al. 1999, 2002). Every school beginner from preselected geographical areas was invited to participate in a questionnaire investigation, and every second child was asked to do lung function measurements. Rural areas without heaW industrial impact were Salzwedel and Osterburg in East Germany and Borken in West Germany; urban areas with industrial impact were Halle-Centre, Leipzig-Southwest, and Magdeburg-Centre in East Germany and Duisburg-North and Duisburg-South in West Germany. Essen-Centre and Cologne-Centre in West Germany were urban areas with strong traffic burden. Lung function was recorded in East Germany in 1991, 1994, and 1997 and in West Germany in 1991, 1994, 1997, and 2000. Study design. Consecutive cross-sections of school beginners were investigated to estimate the effect of outdoor pollution with TSPs and living near a road with heavy traffic on lung function. Measurements of lung function were Raw and TLC. Covariates were age, sex, height, body mass index (BMI BMI body mass index. BMI abbr. body mass index Body mass index (BMI) A measurement that has replaced weight as the preferred determinant of obesity. ) > 18.4 kg/[m.sup.2] (95th percentile percentile, n the number in a frequency distribution below which a certain percentage of fees will fall. E.g., the ninetieth percentile is the number that divides the distribution of fees into the lower 90% and the upper 10%, or that fee level of BMI of study children from East German urban areas in 1991), birth weight < 2,400 g (5th percentile of birth weights of study children from East German urban areas in 1991), parental education [highest achieved grade of schooling of either parent; we distinguished two grades, [less than or equal to] 10th grade (American grade "high school") and > 10 years of schooling (American grade "college and higher degrees")], bedroom sharing (one or more people share the child's bedroom), single room heating with fossil fuels fossil fuel: see energy, sources of; fuel. fossil fuel Any of a class of materials of biologic origin occurring within the Earth's crust that can be used as a source of energy. Fossil fuels include coal, petroleum, and natural gas. , cooking with gas, tobacco smoke exposure considering passive smoking at home and/or maternal smoking in pregnancy, and outdoor temperature < 0[degrees]C at the day of investigation. Lung function. We tested lung function with a constant volume body plethysmograph Noun 1. body plethysmograph - plethysmograph consisting of a chamber surrounding the entire body; used in studies of respiration plethysmograph - a measuring instrument for measuring changes in volume of a part or organ or whole body (usually resulting from apparatus from Jaeger jaeger (yā`gər), common name for several members of the family Stercorariidae, member of a family of hawklike sea birds closely related to the gull and the tern. The skua is also a member of this family. (Wurzburg, Germany). Principles of this technique were summarized by Ulmer et al. (1991). Testing was done with the same mobile body plethysmograph and the same experienced team of examiners in all regions and over all the years of study. The lung function of children suffering from acute airway airway /air·way/ (-wa) 1. the passage by which air enters and leaves the lungs. 2. a device for securing unobstructed respiration. infection was not recorded because this could confound con·found tr.v. con·found·ed, con·found·ing, con·founds 1. To cause to become confused or perplexed. See Synonyms at puzzle. 2. the results. The investigations were conducted in early spring in East Germany and in late spring in West Germany. Several tests on a child were performed for each respiratory maneuver. Registering began with normal respiration respiration, process by which an organism exchanges gases with its environment. The term now refers to the overall process by which oxygen is abstracted from air and is transported to the cells for the oxidation of organic molecules while carbon dioxide (CO for determining [R.sub.aw], followed by maximal max·i·mal adj. 1. Of, relating to, or consisting of a maximum. 2. Being the greatest or highest possible. expiration EXPIRATION. Cessation; end. As, the expiration of, a lease, of a contract, or statute. 2. In general, the expiration of a contract puts an end to all the engagements of the parties, except to those which arise from the non- fulfillment of obligations created and maximal slow inspiration for determining TLC. This method of measurement is precisely described by Coates et al. (1997). We used the child's mean values for [R.sub.aw] for analysis; however, only observations of those children where the measured values of [R.sub.aw] varied < 0.3 kPa-sec/L were included. The chosen value of TLC was the maximum of valid single measurements. Valid measurements of TLC were those where the simultaneously registered inspiratory capacity inspiratory capacity n. The volume of air that can be inhaled after normal inspiration. Also called complementary air. lung volumes was within 80-140% of the child's averaged intrathoracic gas volume. Exposure. Daily and annual mean values of TSPs and sulfur dioxide sulfur dioxide, chemical compound, SO2, a colorless gas with a pungent, suffocating odor. It is readily soluble in cold water, sparingly soluble in hot water, and soluble in alcohol, acetic acid, and sulfuric acid. were determined by the regional authorities of Northrhine Westfalia (West German study sites) [Landesamt for Immissionsschutz des Landes Nordrhein-Westfalen (LUA LUA Landesumweltamt LUA Limited User Account LUA Least-privileged User Account (Microsoft) LUA Logical Unit Application (Microsoft) LUA Launch Under Attack LUA Lukla, Nepal - Lukla ) 1990], Saxony Saxony (săk`sənē), Ger. Sachsen, Fr. Saxe, state (1994 pop. 4,901,000), 7,078 sq mi (18,337 sq km), E central Germany. Dresden is the capital. (Leipzig) (Bezirkshygieneinstitut Leipzig 1990), and Saxony-Anhalt (East German study sites except Leipzig) (Bezirkshygieneinstitut Magdeburg 1990) by the same methods: radiometric technique ([beta]-ray absorption monitor) for determination of TSPs and ultraviolet An invisible band of radiation at the upper end of the visible light spectrum. With wavelengths from 10 to 400 nm, ultraviolet starts at the end of visible light and ends at the beginning of X-rays. The primary source of ultraviolet light is the sun. fluorescence fluorescence (fl  rĕs`əns), luminescence in which light of a visible color is emitted from a substance under stimulation or excitation by light or other forms of electromagnetic method for
determination of S[O.sub.2]. Children's exposure to outdoor TSPs
and S[O.sub.2] was characterized char·ac·ter·ize tr.v. character·ized, character·iz·ing, character·iz·es 1. To describe the qualities or peculiarities of: characterized the warden as ruthless. 2. by the mean of the values gained at the monitoring station(s) (1-3) in the investigation areas. These were either mean values of the year before the study (chronic) or the mean values of the investigation day (short-term). The measurement stations for TSPs and S[O.sub.2] were built to represent urban or rural large-scale background exposures. Therefore, they are situated far from industrial sources or roads with heavy traffic. These stations may not adequately describe exposure of children who live near roads. Parents were asked "How far away is your address (beeline bee·line n. A direct, straight course. intr.v. bee·lined, bee·lin·ing, bee·lines To move swiftly in a direct, straight course. ) from a busy street (rush hour traffic/through traffic)," and answer categories were predefined as "< 50 m" and "> 50 m." We used this information to define two categories (high and low) of traffic exposure. This assessment was validated in the group of children from West Germany in 2000 where geocoded addresses and a road network with traffic density data were available. We calculated daily traffic flow within a circular neighborhood of 50 m radius around a child's address as the sum of all products of number of cars per day times the length of its street section for all segments of this network located within the circle. These traffic densities data were compared for children with high and with low traffic exposure as determined by questionnaire assessment. The outdoor temperature was measured during the day of investigation at the place of the mobile body plethysmograph and included in the analysis as daily mean temperature. Questionnaire. We derived covariates from a questionnaire, which was sent to the parents along with the invitation to the school entrance examination, which is compulsory in Germany. On the day of investigation, the questionnaire was checked by physicians from the local health authorities and subsequently completed by the parents. Height and weight of the children were measured using standardized standardized pertaining to data that have been submitted to standardization procedures. standardized morbidity rate see morbidity rate. standardized mortality rate see mortality rate. procedures by the assistants of the local health authorities. The ethical committee of the Medical Association of Saxony Anhalt approved the study. Written informed consent was obtained from the parents. Statistical analyses. Only children with German nationality nationality, in political theory, the quality of belonging to a nation, in the sense of a group united by various strong ties. Among the usual ties are membership in the same general community, common customs, culture, tradition, history, and language. living > 2 years at their residence were included. Furthermore, asthmatic children were excluded to evade e·vade v. e·vad·ed, e·vad·ing, e·vades v.tr. 1. To escape or avoid by cleverness or deceit: evade arrest. 2. a. effects of broncholytic medication. All analyses were done by linear regression Linear regression A statistical technique for fitting a straight line to a set of data points. on logarithmically log·a·rithm n. Mathematics The power to which a base, such as 10, must be raised to produce a given number. If nx = a, the logarithm of a, with n as the base, is x; symbolically, logn a = x. transformed lung function measurements. All covariates mentioned above were included in the regression models. We tested homogeneity Homogeneity The degree to which items are similar. of TSP effects on children from East and West Germany as well as on children living in proximity to and at a distance from busy streets by including product terms. We also tested the TSP effects on TLC and [R.sub.aw] by including a linear term for trend (study year). The estimated parameters of the regression models were expressed as geometric means (mathematics) geometric mean - The Nth root of the product of N numbers. If each number in a list of numbers was replaced with their geometric mean, then multiplying them all together would still give the same result. ratios (MRs) of the respective lung function variable for an increment To add a number to another number. Incrementing a counter means adding 1 to its current value. of one unit of continuous variables or for 1 versus 0 of binary variables, adjusted for the remaining covariates. The unit for TSPs was 40 [micro]g/[m.sup.3], which is the span between the 5th and 95th percentile of occurring annual mean values. Possible clustering by area was accounted for by random effect modeling. All statistical analyses were done with SAS (1) (SAS Institute Inc., Cary, NC, www.sas.com) A software company that specializes in data warehousing and decision support software based on the SAS System. Founded in 1976, SAS is one of the world's largest privately held software companies. See SAS System. (version 8.2 for Windows NT (Windows New Technology) A 32-bit operating system from Microsoft for Intel x86 CPUs. NT is the core technology in Windows 2000 and Windows XP (see Windows). Available in separate client and server versions, it includes built-in networking and preemptive multitasking. ; SAS Institute SAS Institute Inc., headquartered in Cary, North Carolina, USA, has been a major producer of software since it was founded in 1976 by Anthony Barr, James Goodnight, John Sall and Jane Helwig. Inc., Cary, NC, USA). Regression models were computed with the procedure GENMOD (SAS Institute Inc.). Results Response. Lung function data were available for 3,540 children (response, 69% in West and 73% in East Germany). Children of non-German nationality (n = 596), children living < 2 years at their place of residence (n = 401), and children suffering from asthma (n = 64) were excluded from the analysis. This resulted in 2,574 children with valid data for Raw and 2,066 children with valid data for TLC. Three percent of the children had no valid measurement for [R.sub.aw], and 22% had no valid measurement of TLC. No lung function differences were found between children with and without valid TLC measurement. Both groups showed identical mean Raw of 0.63 kPa x sec/L. The lower rate of valid values for TLC compared with [R.sub.aw] is plausible, because TLC measurement requires some motivation for a respiratory maneuver, whereas [R.sub.aw] is virtually independent from collaboration. The final group for analysis consisted of 2,275 children where information on all covariates was available. Exposure. Table 1 shows that TSP and S[O.sub.2] concentrations in outdoor air decreased mainly in East Germany; however, a slight decrease was also found in West Germany. When the study started in 1991, the annual mean TSP concentrations in East Germany exceeded West German concentrations by a factor up to 1.5, and the daily mean concentrations were up to three times higher in East than in West Germany. Already in 1994, annual TSP levels were similar in East and West Germany. The annual and daily mean TSP concentrations were moderately correlated cor·re·late v. cor·re·lat·ed, cor·re·lat·ing, cor·re·lates v.tr. 1. To put or bring into causal, complementary, parallel, or reciprocal relation. 2. (r = 0.68). Autocorrelation Autocorrelation The correlation of a variable with itself over successive time intervals. Sometimes called serial correlation. of TSP concentration values at the day of investigation compared with the day before was r = 0.83. Differences in S[O.sub.2] between East and West Germany and the decrease of S[O.sub.2] in East Germany were much stronger than for TSPs: The annual mean S[O.sub.2] concentrations in East Germany exceeded West German concentrations by a factor up to 5, and the daily mean concentrations were > 10 times higher in East than in West Germany. S[O.sub.2] and TSPs were highly correlated. Annual means showed a correlation coefficient Correlation Coefficient A measure that determines the degree to which two variable's movements are associated. The correlation coefficient is calculated as: of 0.82 and daily means of 0.82. Since 1997, annual S[O.sub.2] levels were similar in East and West. The annual and daily mean S[O.sub.2] concentrations were more strongly correlated (r = 0.91) than TSP concentrations. Autocorrelation of S[O.sub.2] concentration values at the day of investigation compared with the day before was r = 0.91. Parent's judgment about distance to a busy street (Table 2) was tested by comparing the two exposure groups with respect to objective measure of traffic density in the subsample sub·sam·ple n. A sample drawn from a larger sample. tr.v. sub·sam·pled, sub·sam·pling, sub·sam·ples To take a subsample from (a larger sample). of children in West Germany 2000, where geocoded residential addresses and data of traffic density were available. Mean traffic density within 50 m radius around the children's addresses of those claiming high traffic exposure was 216 traveled km/day [no significant differences between the rural Borken (241 km/day) and the urban Duisburg (204 km/day)], and for those claiming low traffic exposure it was 34 traveled km/day (26 in Borken and 41 in Duisburg). The difference between means of traffic exposure groups was highly significant (Wilcoxon test Wilcoxon test a test used in statistics to compare paired data. Has the advantage of incorporating the size of the difference between the two sets of data in the comparison. , p < 0.000001). Covariates. A description of covariates and traffic exposure is given in Table 2. School beginners were slightly younger in East than in West Germany because of the earlier examination phase in East Germany. The prevalence of the adverse lifestyle factors: heating with fossil fuels, gas for cooking, and environmental tobacco smoke environmental tobacco smoke (ETS/passive smoke), n the gaseous by-product of burning tobacco products, including but not limited to commercially manufactured cigarettes and cigars; contains toxic elements harmful to the health of adults and children , respectively, decreased strongly in East and slightly in West Germany since 1991. Low birth weight decreased and BMI increased in East as well as in West Germany. In West Germany, parental educational level seemed to be lower in 2000 than in 1991, perhaps because of the selection of different study subareas in the West German study areas. Some East German school beginners in 1991 and 1994 were investigated while outdoor temperatures were < 0[degrees]C, which can elevate el·e·vate tr.v. ele·vat·ed, ele·vat·ing, ele·vates 1. To move (something) to a higher place or position from a lower one; lift. 2. To increase the amplitude, intensity, or volume of. 3. [R.sub.aw]. Association of TSPs and distance to a busy road with lung function. Table 3 shows mean crude lung function parameters grouped by study year and part of Germany. The results of the regression analysis In statistics, a mathematical method of modeling the relationships among three or more variables. It is used to predict the value of one variable given the values of the others. For example, a model might estimate sales based on age and gender. are presented in Table 4. The interaction between annual mean TSPs and traffic exposure on TLC was significant (MR = 1.02 for TSP effect living near a busy road/TSP effect living far from a busy road, p = 0.0004), indicating that the decrease of TLC per unit TSPs was smaller for children living near a busy road than for those living far away from it. The interaction between daily mean TSPs and traffic exposure on [R.sub.aw] was also significant (MR = 0.98, p < 0.0001). The interaction between TSPs and region (East/West) on TLC was not significant, indicating that the TSP effect on TLC was the same in East and in West Germany. This interaction, however, was significant for [R.sub.aw]. To facilitate interpretation, the results are also presented stratified stratified /strat·i·fied/ (strat´i-fid) formed or arranged in layers. strat·i·fied adj. Arranged in the form of layers or strata. by region (East/West) and distance from a busy road in Table 5. In children living farther away from a busy road, [R.sub.aw] showed a positive association with short-term TSP exposure (mean on the day of investigation) for children from East Germany but no association for children from West Germany. Mutual adjusting of annual TSPs with annual S[O.sub.2] and daily TSPs with daily S[O.sub.2] resulted in loss of significance and a paradoxical direction of short-term TSP effect on [R.sub.aw] in East Germany (data not shown). TLC was about 3% smaller for children living in residential areas where TSP annual means were increased by 40 [micro]g/[m.sub.3] when they additionally lived near a busy street. This result was not significant. However, children dwelling far from busy roads had a TLC reading > 6% lower when their home was located in a region where TSP annual means were increased by 40 [micro]g/[m.sub.3]. Figure 1 represents this result graphically. Comparing Figure 1A and 1B shows that the effect of broad-scale TSPs on TLC is stronger when only considering children living far from a busy road. The regression coefficients Regression coefficient Term yielded by regression analysis that indicates the sensitivity of the dependent variable to a particular independent variable. See: Parameter. regression coefficient (Table 5) were similar in East and West Germany. The effects did not change when not mutually adjusting for short-term TSPs. An additional effect of short-term exposure on TLC could not be detected. The chronic TSP effect on TLC scarcely differed when adjusting for annual S[O.sub.2] (data not shown). [FIGURE 1 OMITTED] An overall effect of living near a busy road on [R.sub.aw] and TLC could be detected in West Germany. In East Germany, this effect emerged only when restricting the analysis to children investigated from 1994 onward on·ward adj. Moving or tending forward. adv. also on·wards In a direction or toward a position that is ahead in space or time; forward. (Table 6). Sensitivity analysis. We excluded asthmatics because medication use could confound both the individual observations and the changing trends over time. On the other hand, children with asthma might be more susceptible to air pollution exposures. We therefore repeated the analysis without excluding asthmatic children. As found by Gauderman et al. (2004), effects in the total group and in the group excluding children with asthma did not differ substantially. All effects in the total group, however, were less pronounced: the means ratio for the association between TLC and TSPs in East Germany was 0.962 instead of 0.961, and in West Germany was 0.956 instead of 0.953. Big differences as well as massive changes in indoor combustion sources existed between East and West Germany. In our analyses we adjusted for indoor combustion sources. Additionally, we stratified the data by indoor sources and repeated the analysis for the group without special sources. The results did not change, and all associations between TSPs and lung function stayed significant, when excluding children heating their home with fossil fuels; for example, the long-term effect on TLC only differed by about 1% with respect to the means ratio. To account for unknown factors changing over time, we additionally adjusted for trend. The effect estimates for TLC and annual mean TSPs in children living > 50 m from a busy road changed from 0.938 to 0.957 but was still significant. The effect estimate for [R.sub.aw] and daily TSPs for East German children living > 50 m from a busy road changed from 1.025 to 1.027 and remained significant. There is evidence to suggest that short-term effects of particulate matter (PM) may be strongest 2-5 days after the exposure (Delfino et al. 2004). Therefore, we considered modeling different lags of TSP exposure and included in the analysis TSP values from the day before the investigation or the means from the week before the investigation instead of the values on the day of investigation. All these measures were highly correlated (TSPs on the day of investigation with TSPs the day before, r = 0.83; TSPs on the day of investigation with the of the week before, r = 0.82), and the effect estimates did not change; that is, all relative differences of means ratios between models of different lags were < 1%. Discussion In 1991, 6-year-old children in East Germany had poorer lung function values than did children in West Germany: [R.sub.aw] was higher and TLC lower in East than in West German children. East/West differences in lung function diminished between 1991 and 1997. At the same time, the East/West differences in TSP concentrations (daily and annual) also diminished. Lower concentrations of TSPs were associated with better measure of lung function in 6-year-old children. TLC was mostly affected by chronic exposure and [R.sub.aw] by short-term exposure. Traffic-related exposure had a negative impact on lung function, and for children living near roads with heavy traffic, the positive effect of lower TSP concentrations was smaller. Although young children might be especially vulnerable to air pollution health effects (Kim 2004; Mathieu-Nolf 2002), data on lung function for this group of children are rarely presented because lung function measurements using the usual spirometric device depend on children's cooperation. We therefore used a mobile body plethysmographic device. The TLC measurements, however, require a small amount of cooperation, which might explain the 22% nonvalid TLC measurements. We have no indication that the observed TLC results were in any way distorted by the lower number of valid measurements. [R.sub.aw] in children with and without valid TLC measurements was found to be equal. The overall response rate to our study was reasonable (72%). We assume that our results are not biased by any changes in measuring lung function, because one team examined all the children using the same equipment, same method of measuring, and the same calculations throughout the study period. However, these restrictions had the disadvantage that the investigations in East Germany could not be done simultaneously with those in West Germany; they always preceded them. Because climate and pollen exposure differed between February/March (investigations in East Germany) and April/May (investigations in West Germany), a possible distortion of the East/West German comparison had to be considered. The convergence of mean lung function parameters between 1991 and 1997 is probably not caused by the timing of the studies because in all years the investigations were done in the same months in East and West Germany. Differences in seasonal factors could influence East/West comparisons in lung function over time if they influence lung function and change differently over the investigation years in East and West Germany. Among factors that might have introduced seasonal variation in lung function are outdoor temperature, acute infections, and pollen exposure. Temperature was adjusted for in the present analysis. No additional effects on lung function of outdoor temperature > 0[degrees]C could be detected, and the temperature differences between the East and West German investigation times did not change in a systematic way (7.4[degrees]C in 1991, 8.9[degrees]C in 1995, and 4.7[degrees]C in 1997). Children with acute respiratory infections Noun 1. respiratory infection - any infection of the respiratory tract respiratory tract infection infection - the pathological state resulting from the invasion of the body by pathogenic microorganisms were excluded from the analysis. The birch birch, common name for some members of the Betulaceae, a family of deciduous trees or shrubs bearing male and female flowers on separate plants, widely distributed in the Northern Hemisphere. pollen season was always included in the investigation time in West Germany but never in East Germany. There was a trend to earlier birch pollen seasons; however, the seasonal mean pollen concentration showed no trend (p = 0.3), and we could detect no effect of pollen exposure on lung function in nonasthmatic children ([R.sub.aw]: MR = 0.998, p = 0.291; TLC: MR = 0.999, p = 0.346). The stronger effect of short-term TSP exposure on [R.sub.aw] in East Germany compared with West Germany, however, could be partially because short-term TSP concentrations were higher in early spring (investigation in East Germany) than in late spring (investigation in West Germany). Measurements of P[M.sub.10] (PM with aerodynamic diameter Drug particles for pulmonary delivery are typically characterized by aerodynamic diameter rather than geometric diameter. The velocity at which the drug settles is proportional to the aerodynamic diameter, da. < 10 lam) or finer particle fractions were not available during the observation period. In Germany, low-volume samplers were used for measuring TSPs. An oren used conversion factor (P[M.sub.10]/TSPs) is 0.86 (Gehrig and Hofer 2000), which seems to be quite constant even during 1991-2000 in East Germany (Heinrich J, personal communication). When using this factor, our result of 3.9% (East combined) and 4.7% (West combined) lower TLC in children exposed to 40 [micro]g/[m.sup.3] higher TSPs would transform to 4.6 and 5.4% per 40 [micro]g/[m.sup.3] higher P[M.sub.10]. Other air pollutants pollutants see environmental pollution. such as S[O.sub.2], nitrogen dioxide nitrogen dioxide n. A poisonous brown gas, NO2, often found in smog and automobile exhaust fumes and synthesized for use as a nitrating agent, a catalyst, and an oxidizing agent. Noun 1. , or ozone might have caused effects similar to those we ascribed to TSPs. N[O.sub.2] or [O.sub.3] measurements were available only from 1992 onward. Short-term S[O.sub.2] concentration changed from 242 to 10 [micro]g/[m.sup.3] during the observation period, and annual means changed from 127 to 20 [micro]g/[m.sup.3]. The TSP effects on TLC remained unchanged, whereas the short-term TSP effect on [R.sub.aw] lost significance when additionally adjusting for S[O.sub.2]. Therefore, short-term TSP effects might be due to a combined action of TSPs and S[O.sub.2]. The TSP effect was significant after adjusting for the covariates as presented in Table 2. However, we may have missed some covariates that changed over time. Therefore, in a sensitivity analysis, we additionally adjusted for trend. The long-term effects on TLC and the short-term effects on [R.sub.aw] were statistically significant even after adjusting for trend. Another aspect that adds to the possible causality causality, in philosophy, the relationship between cause and effect. A distinction is often made between a cause that produces something new (e.g., a moth from a caterpillar) and one that produces a change in an existing substance (e.g. of TSPs is that the long-term effects on TLC were nearly equally pronounced in East Germany and in West Germany, where lifestyle was different and changes during 1991-2000 were much less pronounced than they were in East Germany. We found that living next to a busy road had an adverse effect on [R.sub.aw] and TLC. This effect emerged in East Germany only after 1991, indicating strengthening over time. We found that the TSP effects were stronger for children living away from roads with heavy traffic. In this group, [R.sub.aw] was positively associated with short-term TSP concentrations and TLC with long-term concentrations. After reunification, in East Germany the number of automobiles increased: in Saxony (East Germany), from 1.2 million to 2.1 million [Statistisches Landesamt des Freistaates Sachsen (SLFS SLFS Sächsisches Landesamt für Familie und Soziales (Germany) ) 2000]; in Saxony Anhalt (East Germany), from 0.8 million to 1.2 million [Landesamt fur Umweltschutz Sachsen-Anhalt (LAU LAU - Langage a Assignation Unique. A single assignment language for the LAU dataflow machine, Toulouse. ["Pipelining, Parallelism and Asynchronism in the LAU System", J.C. Syre et al, Proc 1977 Intl Conf Parallel Proc, pp. 87-92]. ) 2004]. However, in Northrhine Westphalia (West Germany) the number increased only from 8 million to 9 million [Ministerium fur Verkehr, Energie und Landesplanung des Landes Nordrhein-Westfalen (MVEL MVEL Motor Vehicle Emissions Laboratory ) 2004]. The number of cars per 1,000 inhabitants
The game is based loosely on the concepts from SameGame. changed in East Germany from 245 to 488 between the years 1989 and 1997, resulting in a number nearly equal to that found in West Germany (517). Became of propagation The transmission (spreading) of signals from one place to another. of catalytic converters catalytic converter: see internal-combustion engine. catalytic converter In automobiles, a component of emission control systems used to reduce the discharge of noxious gases from the internal-combustion engine. , PM and nitrogen oxide Noun 1. nitrogen oxide - any of several oxides of nitrogen formed by the action of nitric acid on oxidizable materials; present in car exhausts pollutant - waste matter that contaminates the water or air or soil (N[O.sub.x]) emissions from traffic-related sources in East Germany did not increase proportionally to the increase in automobile numbers, but peaked in 1993 (PM) and 1995 (N[O.sub.x]) and has since declined in the years thereafter [Landesamt fur Umwelt und Geologie, Freistaat Sachsen (LfUG) 1997]. The relative contribution of traffic-related sources to all emissions increased between 1989 and 1997 for PM from 2 to 22% and for N[O.sub.x] from 30 to 48%. A measurement station with traffic exposure in Leipzig, one of our study areas, showed a steady increase of N[O.sub.2] annual means from 39 [micro]g/[m.sup.3] in 1991 to 53 [micro]g/[m.sup.3] in 1996 (LfUG 1997). The number concentration of ultrafine particles (aerodynamic diameter 0.01-0.02 [micro]m) in East Germany increased after 1991 despite decreasing TSP concentrations and decreasing concentrations of fine PM (aerodynamic diameter < 2.5 [micro]m) (Ebelt et al. 2001; Kreyling et al. 2003). Ultrafine particles from automobile emissions vary on a small spatial scale; they disappear exponentially ex·po·nen·tial adj. 1. Of or relating to an exponent. 2. Mathematics a. Containing, involving, or expressed as an exponent. b. with the distance from a major road and reach background levels at a distance of 300 m (Zhu et al. 2002). Similar effects can be observed for other traffic-related air pollutants. In East Germany, overall background TSP concentrations decreased whereas concentrations of certain traffic-related substances near roads with heavy traffic actually increased. Therefore, it seems plausible that the effects of decreasing TSP concentrations in outdoor air are more pronounced in areas that are farther away from roads with heavy traffic, whereas the effects are possibly counteracted by the increasing concentrations of traffic-related pollutants. We did not measure traffic-related substances, but relied on questionnaires. We were able to show in a small validation study that the questionnaire information about a busy road in 50 m distance seems to be a good indicator for traffic in a 50-m radius around the child's address. Lung function of children has been found to be associated with traffic-related exposure in a number of other epidemiologic studies (Brunekreef et al. 1997; Fritz and Herbarth 2001; Wjst et al. 1993). Nevertheless, the counteracting effect of living near a busy road might be caused by factors other than air pollution; for example, proximity to a busy street would result in less ability to play outdoors because of high volumes of traffic in front of the home. We are not aware of any other major epidemiologic study having measured TLC or [R.sub.aw] in 6-year-old children. Therefore, direct comparisons with results of other groups are difficult. However, FVC can act as a surrogate surrogate n. 1) a person acting on behalf of another or a substitute, including a woman who gives birth to a baby of a mother who is unable to carry the child. 2) a judge in some states (notably New York) responsible only for probates, estates, and adoptions. of TLC because 80% of TLC is respirable respirable /res·pir·a·ble/ (re-spir´ah-b'l) 1. suitable for respiration. 2. small enough to be inhaled. res·pi·ra·ble adj. 1. Fit for breathing, as air. and changes of TLC are reflected in changes of FVC in persons without severe respiratory illnesses Noun 1. respiratory illness - a disease affecting the respiratory system respiratory disease, respiratory disorder adult respiratory distress syndrome, ARDS, wet lung, white lung - acute lung injury characterized by coughing and rales; inflammation of the such as emphysema emphysema (ĕmfĭsē`mə), pathological or physiological enlargement or overdistention of the air sacs of the lungs. A major cause of pulmonary insufficiency in chronic cigarette smokers, emphysema is a progressive disease that commonly . Therefore, qualitative and quantitative comparisons are possible. PEF and, to a smaller extent, FE[V.sub.1] are dependent on resistance, and comparisons of effects on [R.sub.aw] with effects on those lung function measures from other studies are possible in a restricted manner. The association of annual TSPs and TLC found in our study shows similarity to the results of the Bitterfeld study in East Germany with repeated cross sections between 1992 and 1999 (Frye et al. 2003). A significant increase of 4.7% of adjusted FVC, but no effect on FE[V.sub.1], was reported in schoolchildren schoolchildren school npl → écoliers mpl; (at secondary school) → collégiens mpl; lycéens mpl schoolchildren school 11-14 years of age, when annual TSPs decreased about 50 [micro]g/[m.sup.3]. Transforming our results to this change of exposure resulted in an increase of 4.9% of TLC. The lack of a long-term TSP effect on [R.sub.aw] in our study agreed with the lack of an effect for FE[V.sub.1] in the Bitterfeld study. Furthermore, the TSP-associated changes in TLC observed in our study can be compared with changes of FVC in southern California Southern California, also colloquially known as SoCal, is the southern portion of the U.S. state of California. Centered on the cities of Los Angeles and San Diego, Southern California is home to nearly 24 million people and is the nation's second most populated region, communities (Peters et al. 1999). The decrease we observed was twice the decrease in southern California: We observed a 76.7-mL decrease of TLC (corresponding to a 61.3-mL decrease of FVC) associated with a TSP change from 40 to 80 [micro]g/[m.sup.3], whereas for the pupils from southern California a 34.3 and 36.9 mL decrease of FVC per increase of 40 [micro]g/[m.sup.3] TSPs (calculated from P[M.sub.10]) was observed. This comparison is affected by different conditions such as age of children and presence of other copollutants, but exposure of PM was in a similar range of concentration, suggesting that our results and the results of the Bitterfeld study (Frye et al. 2003) might overestimate o·ver·es·ti·mate tr.v. o·ver·es·ti·mat·ed, o·ver·es·ti·mat·ing, o·ver·es·ti·mates 1. To estimate too highly. 2. To esteem too greatly. the effect of TSPs. It is likely that trend of air pollution and trend of other factors is not separable sep·a·ra·ble adj. Possible to separate: separable sheets of paper. sep during the period of German reunification. However, the regression coefficients for the independent variable TSPs with respect to the dependent variable TLC were nearly identical for both parts of Germany. This hints at a causal effect of TSPs not confounded by trend. Conclusions This study compares lung function in 6-year-old children in East and West Germany during a time of decreasing concentrations of outdoor TSPs in East Germany. The children investigated were of ethnic homogeneity but differed in lifestyle and air pollution exposure. These differences diminished during the time of observation. No other study is available comparing results from East and West Germany during this critical time of changes. TLC showed a clear association with long-term concentrations of TSPs; [R.sub.aw] was affected by short-term outdoor concentrations in East Germany. Thus, the reduction in TSPs was associated with better lung function when comparing repeated cross sections in 6-year-old children. However, there was an increasing effect of traffic-related pollution in East Germany, and the favorable fa·vor·a·ble adj. 1. Advantageous; helpful: favorable winds. 2. Encouraging; propitious: a favorable diagnosis. 3. effects were presumably pre·sum·a·ble adj. 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LfUG. 1997. Jahresberichte zur Immissionssituation 1991-1997. Dresden, Germany:Landesamt fur Umwelt und Geologie, Freistaat Sachsen. LUA. 1990. Temes-Monatsberichte uber die Luftqualitat in Nordrhein-Westfalen. Essen, Germany:Landesanstalt fur Immissionsschutz des Landes Nordrhain-Westfalen. Mathieu-Nolf M. 2002. Poisons in the air: a cause of chronic disease in children. J Toxicol Clin Toxicol 40:483-491. MVEL. 2004. Mobilitat in NRW NRW Nordrhein-Westfalen (German Federal State; Capital Düsseldorf) NRW Non-Revenue Water NRW Northern Right Whale NRW Nicolson-Ross-Weir (measurement technique) NRW Nonradioactive Waste , Daten und Fakten 2004. Dusseldorf, Germany:Ministerium fur Verkehr, Energie und Landesplanung des Landes Nordrhein-Westfalen. Peacock JL, Symonds P, Jackson P, Bremner SA, Scarlett JF, Strachan DP, et al. 2003. Acute effects of winter air pollution on respiratory function in schoolchildren in southern England Southern England is an imprecise term used to refer to the southern counties of England. Differing usages apply the term with varying geographic extents. In most definitions Southern England includes all the counties on the English Channel; from west to east these are: Peters JM, Avol E, Gauderman WJ, Linn linn n. Scots 1. A waterfall. 2. A steep ravine. [Scottish Gaelic linne, pool, waterfall.] WS, Navidi W, London SJ, et al. 1999. A study of twelve southern California communities with differing levels and types of air pollution. Am J Respir Crit Care Med 159:768-778. Pope CA III CA III Challenge Athena version III (Navy SATCOM link) . 2000. Epidemiology of fine particulate par·tic·u·late adj. Of or occurring in the form of fine particles. n. A particulate substance. particulate composed of separate particles. air pollution and human health: biologic mechanisms and who's at risk? Environ Health Perspect 108(suppl 4):713-723. Schindl R. 1983. Einfluss der Umweltfaktoren suf die Lungenfunktion. Screeninguntersuchung mit Flow-Volumen bei Schulkindern in Stadt und Land. Z Erkr Atmungsorgane 161:199-203. Schindler C, Kunzli N, Bongard JP, Leuenberger P, Karrer W, Repp R, et al. 2001. Short-term variation in air pollution and in average lung function among never-smokers. Am J Respir Crit Care Med 163:355-361. Schwartz J. 1989. Lung function and chronic exposure to air pollution: a cross-sectional analysis Cross-sectional analysis Assessment of relationships among a cross-section of firms, countries, or some other variable at one particular time. of NHANES NHANES National Health and Nutrition Examination Survey (US CDC) II. Environ Res 50:309-321. SLFS. 2000. Sachsen im Uberblick 10 Jahre deutsche Einheit. Ksmenz, Dermany:StaLa Sachsen. Ulmer WT, Reichel G, Nolte D, Islam MS, eds. 1991. Die Lungenfunktion. Physiologie und Pathuphysiologie, Methodik. Stuttgart:Georg Thieme Verlag. Wang X, Dockery DW, Wypij D, Fay ME, Ferris BG Jr. 1993a. Pulmonary function between 6 and 18 years of age. Pediatr Pulmonul 15:75-88. Wang X, Dockery DW, Wypij D, Gold DR, Speizer FE, Ware JH, et al. 1993b. Pulmonary function growth velocity in children 6 to 18 years of age. Am Rev Respir Dis 148:1502-1508. Wjst M, Reitmeir P, Dold S. 1993. Road traffic and adverse effects on respiratory health in children. BMJ BMJ n abbr (= British Medical Journal) → vom BMA herausgegebene Zeitschrift 307:596-600. Zhu Y, Hinds Hinds may refer to: People with the surname Hinds:
Address correspondence to D. Sugiri, Institut fur umweltmedizinische Forschung an der Heinrich-Heine-Universitat Dusseldorf, 40225 Dusseldorf, Germany. Telephone: 49-211-3389-299. Fax: 49-211-3389-283. E-mail: sugiri@uni-duesseldoff.de We thank M.S. Islam and his team for their excellent body plethymographic measurements: E. Muller Mul·ler , Hermann Joseph 1890-1967. American geneticist. He won a 1946 Nobel Prize for the study of the hereditary effect of x-rays on genes. Mül·ler , Johannes Peter 1801-1858. , S. Wolczyk, V. Jaeger, and G. Seimer-Sorge. We thank the local health departments in Borken, Cologne Cologne (kəlōn`), Ger. Köln, city (1994 pop. 962,500), North Rhine–Westphalia, W Germany, on the Rhine River. It is a commercial, financial, and industrial center, a rail and road junction, and a river port. , Duisburg, Essen, Halle, Leipzig, Magdeburg, Osterburg, and Salzwedel for their assistance and permission to couple our investigations with the official school entrance examinations. Thanks also to H. Wilier and H. Oppermann, who enabled the fieldwork field·work n. 1. A temporary military fortification erected in the field. 2. Work done or firsthand observations made in the field as opposed to that done or observed in a controlled environment. 3. in East Germany, and R. Dolgner, who organized the study in West Germany. We also thank J. Edmonds (Environmental Health Officer in Stonnington, Victoria, Australia). The study was partly financed by the Ministry of the Environment of North-Rhine Westphalia and the Ministry of Social Affairs in Sachsen-Anhalt. The authors declare they have no competing financial interests. Received 6 April 2005; accepted 19 September 2005. Institut fur umweltmedizinische Forschung an der Heinrich-Heine-Unviversitat Dusseldorf, Dusseldorf, Germany
Table 1. Distribution of TSPs and S[O.sub.2] exposure
([micro]g/[m.sup.3]) from the previous year and from the day of
investigation for the children, and regression analysis of the
logarithmic transformed TSPs and S[O.sub.2] exposure for trend
(10 years), region (East vs. West), and their interaction (trend East
vs. trend West).
West Germany
1991 1994 1997 2000
TSPs from the previous year
No. 196 282 148 307
Mean 54.35 52.22 56.11 44.20
SD 2.69 3.07 2.45 4.73
Min 50.00 48.00 53.00 40.00
Max 56.00 55.00 59.00 50.00
TSPs on day of examination
No. 196 282 148 287
Mean 51.01 53.87 45.65 49.75
SD 21.81 17.69 15.88 20.20
Min 13.00 19.60 24.60 20.00
Max 83.00 110.3 102.9 96.00
S[O.sub.2] from the previous year
No. 196 282 148 307
Mean 27.25 19.73 18.27 10.07
SD 6.94 3.80 2.90 3.40
Min 18.00 17.00 14.00 6.00
Max 34.00 26.00 21.00 14.00
S[O.sub.2] on day of examination
No. 196 261 139 301
Mean 19.81 13.15 12.21 8.75
SD 13.61 6.42 5.88 6.15
Min 5.00 5.00 5.00 5.00
Max 57.00 30.70 30.90 38.00
East Germany
1991 1994 1997
TSPs from the previous year
No. 903 493 322
Mean 74.45 55.68 51.29
SD 5.37 3.44 10.80
Min 66.00 50.00 44.00
Max 81.00 59.00 73.00
TSPs on day of examination
No. 903 456 322
Mean 127.90 68.79 49.65
SD 35.33 37.68 29.61
Min 46.00 23.40 20.00
Max 208.0 182.2 122.0
S[O.sub.2] from the previous year
No. 903 493 322
Mean 126.90 57.65 20.19
SD 53.23 21.23 4.63
Min 64.00 37.00 16.00
Max 178.00 93.00 26.00
S[O.sub.2] on day of examination
No. 903 429 322
Mean 241.50 79.05 10.24
SD 136.90 62.73 6.01
Min 35.13 15.06 3.00
Max 576.0 261.3 31.00
MR (95% CI) (a)
Trend East/West
TSPs from the previous year
No.
Mean 0.80 * 1.37 *
SD (0.67-0.96) (1.24-1.52)
Min
Max
TSPs on day of examination
No.
Mean 0.96 2.98 *
SD (0.74-1.23) (2.39-3.71)
Min
Max
S[O.sub.2] from the previous year
No.
Mean 0.33 * 5.06 *
SD (0.26-0.43) (3.08-8.30)
Min
Max
S[O.sub.2] on day of examination
No.
Mean 0.46 * 20.8 *
SD (0.33-0.63) (14.3-30.3)
Min
Max
MR (95% CI)
(a)
Trend East/
trend West
TSPs from the previous year
No.
Mean 0.62 *
SD (0.48-0.80)
Min
Max
TSPs on day of examination
No.
Mean 0.16 *
SD (0.10-0.26)
Min
Max
S[O.sub.2] from the previous year
No.
Mean 0.17 *
SD (0.10-0.31)
Min
Max
S[O.sub.2] on day of examination
No.
Mean 0.02 *
SD (0.01-0.03)
Min
Max
Abbreviations: CI, confidence interval; Max, maximum; Min, minimum.
(a) MR and 95% CI for trend (10 years), region (East/West), interaction
(trend East/trend West), results of linear mixed model analysis, area
(exposure from the previous year), or date (exposure from the day of
investigation) treated as marginal effect. * Significant effects
(p < 0.05).
Table 2. Characteristics of the study group nonasthmatic German
children living at least 2 years at their place of residence.
West Germany
Characteristic 1991 1994 1997 2000
No. 196 282 148 307
Age [mean (years)] 6.4 6.4 6.4 6.4
Height [mean (cm)] 120.9 121.1 120.5 120.5
Male sex (%) 50.5 47.9 43.2 46.9
Birth weight < 2,400 g (%) 7.2 4.3 4.1 5.6
BMI > 18.4 kg/[m.sup.2] (%) 7.7 8.5 10.8 12.4
Temperature < 0[degrees]C at day of
examination (%) 0.0 0.0 0.0 0.0
Fossil-fuel heating at home (%) 13.1 24.3 16.4 6.8
Gas cooking at home (%) 8.3 8.9 4.8 3.9
Parental education school years
[greater than or equal to] 10 (%) 53.9 50.2 67.6 70.8
Bedroom sharing (%) 58.8 53.0 41.5 52.8
Tobacco smoke exposure (a) (%) 59.3 55.6 50.7 35.9
Traffic exposure (b) (%) 45.9 63.1 59.5 46.4
East Germany
Characteristic 1991 1994 1997
No. 903 498 322
Age [mean (years)] 6.3 6.1 6.2
Height [mean (cm)] 119.3 119.8 120.8
Male sex (%) 52.0 50.0 57.3
Birth weight < 2,400 g (%) 5.2 3.9 4.1
BMI > 18.4 kg/[m.sup.2] (%) 6.0 7.9 9.0
Temperature < 0[degrees]C at day of
examination (%) 41.0 15.4 0.0
Fossil-fuel heating at home (%) 69.4 44.5 26.1
Gas cooking at home (%) 73.0 56.7 33.5
Parental education school years
[greater than or equal to] 10 (%) 49.1 55.6 49.2
Bedroom sharing (%) 64.8 57.5 42.7
Tobacco smoke exposure (a) (%) 52.9 49.5 37.6
Traffic exposure (b) (%) 63.0 69.8 56.9
(a) Smoking of mother during pregnancy and/or smoking at child's home.
(b) Living < 50 m from a traffic road.
Table 3. Lung function of nonasthmatic German children living at least
2 years at their place of residence.
West Germany
1991 1994 1997 2000
[R.sub.aw] (kPa x sec/L)
No. 188 275 148 307
Minimum 0.247 0.261 0.427 0.352
25th Percentile 0.467 0.519 0.594 0.546
Median 0.554 0.594 0.673 0.626
75th Percentile 0.678 0.715 0.763 0.704
Maximum 1.008 1.465 1.352 1.015
Arithmetic mean 0.579 0.620 0.698 0.634
TLC (L)
No. 156 188 137 257
Minimum 1.49 1.31 1.50 1.41
25th Percentile 1.95 2.01 1.99 2.02
Median 2.13 2.16 2.11 2.18
75th Percentile 2.35 2.39 2.30 2.38
Maximum 2.71 3.33 2.92 3.08
Arithmetic mean 2.14 2.21 2.15 2.20
East Germany
1991 1994 1997
[R.sub.aw] (kPa x sec/L)
No. 883 451 322
Minimum 0.255 0.309 0.300
25th Percentile 0.553 0.553 0.562
Median 0.651 0.634 0.641
75th Percentile 0.773 0.725 0.749
Maximum 1.710 1.286 1.267
Arithmetic mean 0.672 0.650 0.665
TLC (L)
No. 664 373 291
Minimum 1.22 1.35 1.39
25th Percentile 1.85 1.94 2.00
Median 2.06 2.13 2.19
75th Percentile 2.24 2.36 2.39
Maximum 3.34 2.97 3.50
Arithmetic mean 2.05 2.15 2.20
Table 4. Influence of long-term and short-term TSP concentrations on
lung function of German nonasthmatic children living at least 2 years
at their residence, nonstratified analysis but with interaction terms.
MR (95% CI) (a)
TSPs
No. Annual mean
[R.sub.aw] (kPa x
sec/L) 2,216 0.994 (0.957-1.033)
TLC (L) 1,763 0.938 * (0.884-0.996)
MR (95% CI) (a)
Interaction with TSP
TSPs daily mean
Daily mean Traffic
[R.sub.aw] (kPa x
sec/L) 0.969 * (0.936-1.004) 0.973 * (0.965-0.981)
TLC (L) 0.996 (0.988-1.004) 1.020 * (1.006-1.034)
MR (95% CI) (a)
Interaction with TSP
daily mean
Region Traffic
[R.sub.aw] (kPa x
sec/L) 1.053 * (1.012-1.097) 1.072 * (1.056-1.089)
TLC (L) 1.012 (0.951-1.076) 0.973 * (0.955-0.991)
MR (95% CI) (a)
Region
[R.sub.aw] (kPa x
sec/L) 0.984 (0.925-1.046)
TLC (L) 0.996 (0.909-1.092)
(a) Adjusted MR and 95% CI for 40-[micro]g/[m.sup.3] increase of TSPs,
traffic (living < vs. [greater than or equal to] 50 m from a busy
road), region (East vs. West German sites), and their interactions with
TSPs: Results of linear mixed model analysis adjusted for education,
bedroom sharing, sex, age, height, BMI, birth weight, heating with
fossil fuels, cooking with gas, passive smoking and/or maternal smoking
during pregnancy, outdoor temperature on the day of investigation; area
treated as marginal effect. * Significant effects (p < 0.1).
Table 5. Influence of long-term and short-term TSP concentrations on
lung function of German nonasthmatic children living at least 2 years
at their residence, stratified analysis [MR (95% CI) TSPs]. (a)
West
No. Annual mean Daily mean
[R.sub.aw] (kPa
x sec/L)
Traffic 416 1.111 (0.922-1.338) 0.942 * (0.918-0.967)
Nontraffic 343 1.096 (0.966-1.243) 0.982 (0.938-1.028)
TLC (L)
Traffic 328 0.973 (0.913-1.038) 0.981 * (0.971-0.992)
Nontraffic 278 0.930 * (0.875-0.988) 1.007 (0.976-1.040)
East
No. Annual mean Daily mean
[R.sub.aw] (kPa
x sec/L)
Traffic 927 0.984 (0.945-1.014) 0.996 (0.976-1.016)
Nontraffic 530 0.967 (0.901-1.038) 1.025 * (0.999-1.051)
TLC (L)
Traffic 724 0.969 (0.930-1.009) 0.998 (0.993-1.003)
Nontraffic 433 0.938 * (0.910-0.967) 0.999 (0.985-1.012)
(a) Adjusted MR and 95% CI for 40-[micro]g/[m.sup.3] increase of TSPs:
Results of linear mixed model analysis, adjusted for education, bedroom
sharing, sex, age, height, BMI, birth weight, heating with fossil
fuels, cooking with gas, passive smoking and/or maternal smoking during
pregnancy, outdoor temperature on the day of investigation; area
treated as marginal effect. * Significant effects (p < 0.1).
Table 6. Influence of living near a busy road on lung function of
German nonasthmatic children living at least 2 years attheir residence.
(a)
West
No. MR (95% CI)
[R.sub.aw] (kPa x sec/L) 770 1.019 * (1.003-1.035)
TLC (L) 617 0.994 * (0.991-0.998)
East
No. MR (95% CI)
[R.sub.aw] (kPa x sec/L) 1,488 1.007 (0.989-1.025)
TLC (L) 1,182 1.006 (0.998-1.014)
East 1994/1997
No. MR (95% CI)
[R.sub.aw] (kPa x sec/L) 363 1.021 * (1.005-1.037)
TLC (L) 306 0.989 * (0.986-0.992)
(a) Adjusted MR and 95% CI for living < versus [greater than or equal
to] 50 m away from a busy road: results of linear mixed model analysis,
adjusted for education, bedroom sharing, sex, age, height, BMI, birth
weight, heating with fossil fuels, cooking with gas, passive smoking
and/or maternal smoking during pregnancy, outdoor temperature on the
day of investigation; area treated as marginal effect. * Significant
effects (p < 0.1).
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