The best HDL cholesterol for the heart?High-density lipoprotein (HDL (Hardware Description Language) A language used to describe the functions of an electronic circuit for documentation, simulation or logic synthesis (or all three). Although many proprietary HDLs have been developed, Verilog and VHDL are the major standards. ) is a carrier molecule known as the "good cholesterol" for its role in removing fatty debris from artery walls. Researchers now report that some forms of HDL may provide better protection against heart disease than others.
A particular type of HDL, one that contains a particle dubbed apoA-I, seems to provide superior protection against the ravages of heart disease, says H. Bryan Brewer Jr. of the National Heart, Lung, and Blood Institute National Heart, Lung, and Blood Institute,
n.pr established in 1948, this division of the National Institutes of Health is responsible for research and education on cardiovascular, pulmonary, systemic diseases, and sleep disorders. in Bethesda, Md. His research suggests that HDL with apoA-I collects cholesterol from the inner wall of the artery and transports it to the liver for excretion. Another type of HDL appears ineffective at such cholesterol scavenging scavenging
of anesthetic. See anesthetic scavenging. .
More evidence on the merits on the merits adj. referring to a judgment, decision or ruling of a court based upon the facts presented in evidence and the law applied to that evidence. A judge decides a case "on the merits" when he/she bases the decision on the fundamental issues and considers of apoA-I comes from a mouse study. Edward Rubin of the University of California, Berkeley The University of California, Berkeley is a public research university located in Berkeley, California, United States. Commonly referred to as UC Berkeley, Berkeley and Cal , has put the human gene coding for the apoA-I protein into a strain of mice. The resulting animals have high concentrations of HDL with the human apoA-I particle in their bloodstream.
When Rubin put these mice on a high-fat, high-cholesterol diet, he found that the apoA-I protected them from developing plaque. By contrast, unaltered mice (with normal concentrations of HDL in their bloodstream) did develop coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. when fed the fatty chow.
Of course, such animal studies do not prove apoA-I's benefits in humans, Rubin notes. But this evidence, as well as data from other studies, suggests that HDL with apoA-I may provide people with a more effective shield against heart disease, he says. Brewer agrees, noting that if further research confirms apoA-I's benefits, physicians may begin to order a more sophisticated cholesterol profile, one that includes a breakdown of HDL types.