The G protein-coupled receptors handbook.1588293653
The G protein-coupled receptors G protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR handbook.
Ed. by Lakshmi A. Devi.
Humana Press Inc.
Contemporary clinical neuroscience neu·ro·sci·ence
Any of the sciences, such as neuroanatomy and neurobiology, that deal with the nervous system.
the embryology, anatomy, physiology, biochemistry and pharmacology of the nervous system.
The handbook is intended to provide a comprehensive overview of recent developments in knowledge about the receptors' structure and function, activity and its regulators, dimerization and oligomerization, and role in drug discovery. Researchers mostly in pharmacology but also other fields consider such topics as regulated membrane trafficking and proteolysis proteolysis
Process in which a protein is broken down partially, into peptides, or completely, into amino acids, by proteolytic enzymes, present in bacteria and in plants but most abundant in animals. , heterotrimeric G proteins "G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins. These proteins are activated by G protein-coupled receptors and are made up of alpha (α), beta (β) and gamma (γ) subunits. and their effector effector /ef·fec·tor/ (e-fek´ter)
1. an agent that mediates a specific effect.
2. an organ that produces an effect in response to nerve stimulation. pathways, G protein-coupled receptor kinases, biophysical and biochemical methods to study receptor oligomerization, the modulation of receptor pharmacology by G protein-coupled receptor dimerization, the conformational plasticity of binding sites, de- orphanizing the receptors and drug development.
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