The G protein-coupled receptors handbook.1588293653The G protein-coupled receptors G protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR handbook. Ed. by Lakshmi A. Devi. Humana Press Inc. 2005 412 pages $135.00 Hardcover Contemporary clinical neuroscience neu·ro·sci·ence n. Any of the sciences, such as neuroanatomy and neurobiology, that deal with the nervous system. neuroscience the embryology, anatomy, physiology, biochemistry and pharmacology of the nervous system. QP552 The handbook is intended to provide a comprehensive overview of recent developments in knowledge about the receptors' structure and function, activity and its regulators, dimerization and oligomerization, and role in drug discovery. Researchers mostly in pharmacology but also other fields consider such topics as regulated membrane trafficking and proteolysis proteolysis Process in which a protein is broken down partially, into peptides, or completely, into amino acids, by proteolytic enzymes, present in bacteria and in plants but most abundant in animals. , heterotrimeric G proteins "G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins. These proteins are activated by G protein-coupled receptors and are made up of alpha (α), beta (β) and gamma (γ) subunits. and their effector effector /ef·fec·tor/ (e-fek´ter) 1. an agent that mediates a specific effect. 2. an organ that produces an effect in response to nerve stimulation. pathways, G protein-coupled receptor kinases, biophysical and biochemical methods to study receptor oligomerization, the modulation of receptor pharmacology by G protein-coupled receptor dimerization, the conformational plasticity of binding sites, de- orphanizing the receptors and drug development. ([c] 2005 Book News, Inc., Portland, OR) |
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