Techniques using endovascular repair of major vascular pathology are advancing rapidly.
Endovascular treatment of aortic aortic
pertaining to or emanating from the aorta. See also aortic arch.
occurs most often in dogs, where it is caused by Spirocerca lupi larvae, turkeys and primates, causing dyspnea, cyanosis and coughing. pathologies has obvious appeal: avoiding large surgical incisions, reduced blood loss, eliminating the need for cardiac bypass in complex aortic repairs, reduced intensive care unit (ICU ICU intensive care unit.
intensive care unit
see intensive care unit.
ICU ) stay, less perioperative perioperative /peri·op·er·a·tive/ (-op´er-ah-tiv) pertaining to the period extending from the time of hospitalization for surgery to the time of discharge.
adj. morbidity, earlier ambulation am·bu·late
intr.v. am·bu·lat·ed, am·bu·lat·ing, am·bu·lates
To walk from place to place; move about.
[Latin ambul and shorter hospital stay. The last 10-15 years can be considered as heralding the 'endovascular revolution', and at the forefront of this evolving stent/stentgraft technology was endovascular abdominal aortic aneurysm abdominal aortic aneurysm A focal aortic dilation of ≥ 50% ↑ in diameter, accompanied by distension and weakened aortic wall Epidemiology Incidence is rising 12/105–1951; 36/105 repair (EVAR EVAR Endovascular Aneurysm Repair
EVAR Experimental Vehicle for Avionics Research
EVAR Extravehicular Activity Retriever ).
Since the first descriptions by Balko and the initial clinical experience of Parodi in the early 1990s, stentgraft ('endograft') repair of abdominal aortic aneurysms (AAA AAA: see American Automobile Association.
(Triple A) A common single-cell battery used in a myriad of electronic devices of all variety. Like its double A (AA) cousin, it provides 1.5 volts of DC power. When used in series, the voltage is multiplied. ) has evolved through irrational enthusiasm, followed by cynicism ('endosceptism') for a new technology, to being currently the widely accepted alternative treatment option for AAA repair. Originally conceived as a less invasive alternative to open repair (OR) of AAA in patients with significant medical co-morbidities, EVAR has also been used to treat conventional ('good') risk patients with AAA, despite the lack of proof of long-term efficacy and durability compared with the current gold standard of OR.
Currently, on average over half (range 20-80%) of AAAs are being treated using endovascular techniques worldwide. Evolving stentgraft technology and numerous reports in the last decade have shifted the focus from device safety and efficacy to proof of long-term durability, together with expanding applicability and indications. Despite a 2.5-fold reduction in 30-day mortality rate, EVAR is still plagued by a 3-fold risk of reintervention, 30% greater overall cost and similar overall mortality rates compared with OR.
Aortic stentgrafts: materials and configurations'
Aortic stentgrafts are available in various configurations: tube stentgrafts, tapered stentgrafts (aorto-uniiliac), bifurcated bi·fur·cate
v. bi·fur·cat·ed, bi·fur·cat·ing, bi·fur·cates
To divide into two parts or branches.
To separate into two parts or branches; fork.
adj. stentgrafts ('Y' or trouser graft), fenestrated fenestrated /fen·es·trat·ed/ (fen´es-trat?ed) pierced with one or more openings.
fen·es·trat·ed or fen·es·trate
Having fenestrae or windowlike openings. stentgrafts (with a scallop scallop or pecten, marine bivalve mollusk. Like its close relative the oyster, the scallop has no siphons, the mantle being completely open, but it differs from other mollusks in that both mantle edges have a row of steely blue "eyes" and for the superior mesenteric artery and two reinforced fenestrations for renal artery stents), and branched stentgrafts (with side-arm/s for additional endografting to the mesenteric mesenteric /mes·en·ter·ic/ (-ter´ik) pertaining to the mesentery.
pertaining to or emanating from the mesentery. , renal and supra-aortic vessels) (Fig. 1).
[FIGURE 1 OMITTED]
First-generation aortic stentgrafts were unsupported tube grafts, with initially only proximal and later additional distal fixation stents. Currently these are limited for use only in saccular saccular /sac·cu·lar/ (sak´u-ler) pertaining to or resembling a sac.
pertaining to or resembling a sac. or para-anastomotic AAAs (following previous aortoiliac surgery), and other rare indications. Thoracic stentgrafts (in tube configuration) are available in bigger diameters and in different lengths.
Aorto-uniiliac stentgrafts require a contralateral contralateral /con·tra·lat·er·al/ (-lat´er-al) pertaining to, situated on, or affecting the opposite side.
adj. common iliac 'occluder' cuff and a femoro-femoral crossover bypass graft to preserve flow to the contralateral limb. Current indications include repair of ruptured AAA and associated iliac disease.
The current preferred configuration for EVAR is a bifurcated stentgraft. These are produced either as complete single units ('one-piece' or 'uni-body' device) (Fig. 2) or, more commonly, as a modular device (Fig. 3), consisting of two components (a main body with contiguous ipsilateral ipsilateral /ip·si·lat·er·al/ (ip?si-lat´er-al) situated on or affecting the same side.
Located on or affecting the same side of the body. iliac limb and contralateral iliac extension limb), or three components (a main body with separate ipsilateral and contralateral iliac extension limbs). The aortic component may be extended proximally with an aortic extension cuff, if required.
[FIGURES 2-3 OMITTED]
The graft material consists of polyester fabric or expanded polytetrafluoroethelene (e-PTFE), with most current devices supported throughout by a metal skeleton (endoskeleton endoskeleton /en·do·skel·e·ton/ (en?do-skel´e-ton) the cartilaginous and bony skeleton of the body, exclusive of that part of the skeleton of dermal origin.
n. , exoskeleton exoskeleton /exo·skel·e·ton/ (-skel´e-ton) a hard structure formed on the outside of the body, as a crustacean's shell; in vertebrates, applied to structures produced by the epidermis, as hair, nails, hoofs, teeth, etc. or interwoven in·ter·weave
v. in·ter·wove , in·ter·wo·ven , inter·weav·ing, inter·weaves
1. To weave together.
2. To blend together; intermix.
v.intr. ). The metals used are stainless steel, 'Elgiloy' (nickel, cobalt, and chromium superalloy su·per·al·loy
Any of several complex temperature-resistant alloys. ) or, more commonly, nitinol (nickel-titanium alloy).
Stentgraft fixation ('seal'/'landing' zones)'
Aortic fixation of the stentgraft may be infrarenal (relying on radial compression with or without hooks or barbs attached to the proximal covered stent), or suprarenal suprarenal /su·pra·re·nal/ (-re´nal)
1. above a kidney.
Located on or above the kidney.
n. with uncovered metal stent struts that maintain perfusion of the renal arteries, while the infrarenal covered component provides the seal.
Distally, a seal requires normal common iliac arteries. Associated iliac aneurysms require an external iliac artery Noun 1. external iliac artery - the outer branch of the common iliac artery on either side of the body; becomes the femoral artery
arteria iliaca, iliac artery - one of the large arteries supplying blood to the pelvis and legs landing zone (after coil embolisation or flared stentgraft occlusion of the ipsilateral internal iliac artery internal iliac artery
See internal iliac artery. to prevent backflow backflow /back·flow/ (-flo) reflux or regurgitation (1).
pyelovenous backflow drainage from the renal pelvis into the venous system occurring under certain conditions of back pressure. ). Other options to permit use of aneurysmal aneurysmal
pertaining to or arising from an aneurysm.
aneurysmal bone cyst
see bone cyst. or occlusive occlusive /oc·clu·sive/ (o-kloo´siv) pertaining to or causing occlusion.
1. Occluding or tending to occlude.
2. iliac segments include: use of an iliac conduit (10 mm graft for access via an extraperitoneal approach), internal iliac to external iliac artery bypass grafting, iliac bifurcated stentgrafts, or an iliac occluder cuff with a femoro-femoral crossover bypass graft).
EVAR: principles of Repair
Successful stentgraft exclusion of an AAA requires certain criteria to be fulfilled (Table I).
Successful stentgraft attachment and aneurysm aneurysm (ăn`yrĭzəm), localized dilatation of a blood vessel, particularly an artery, or the heart. exclusion requires a thorough anatomical evaluation and patient selection (Table II).
Peri-procedural imaging and technique
Multi-detector CT angiography angiography
X-ray examination of arteries and veins with a contrast medium to differentiate them from surrounding organs. The contrast medium is introduced through a catheter to show the blood vessels and the structures they supply, including (MDCTA MDCTA Multidetector Computed Tomography Angiography ) is a good preprocedural imaging tool, with various 2-D and 3-D reformatting techniques allowing measurements including centre lumen line measurements for EVAR (Fig. 4).
[FIGURE 4 OMITTED]
Calibrating angiography, transoesophageal echo and intravascular ultrasound (IVUS IVUS Intravascular ultrasound, see there ) are useful adjuncts only for thoracic aortic pathology. The stentgraft should generally be oversized by 15-20% (10-15% for connective tissue disorders, aortic dissections, etc.).
EVAR is performed with local, regional (epidural epidural /epi·du·ral/ (-dur´il) situated upon or outside the dura mater.
Located on or over the dura mater.
n. ) or general anaesthesia (better outcomes associated with local anaesthetic), and usually requires two small groin incisions to expose the femoral arteries. Fluoroscopy fluoroscopy /flu·o·ros·co·py/ (fldbobr-ros´kah-pe) examination by means of the fluoroscope.
Examination by means of a fluoroscope. Also called radioscopy. with C-arm image-intensifiers and angiography with calibrated pigtail catheters ensure precise infrarenal deployment, graft length measurement, modular 'docking' (with sufficient overlap of the components) and distal fixation of the devices (Fig. 5).
[FIGURE 5 OMITTED]
The devices are delivered and deployed over stiff guidewires. Fixation of the stentgraft in the seal zones is aided by use of a large diameter compliant ('moulding') balloon.
Post-procedural surveillance imaging, at 1, 6 and 12 months and thereafter annually, is mandatory and consists of Duplex U/S U/S
U/S Ultrasound , MDCTA (or MR angiography) and plain X-rays. Imaging aims to detect changes in sac diameter and volume, endoleaks, stentgraft migration, etc. (Fig. 6).
[FIGURE 6 OMITTED]
Complications of EVAR
An endoleak is defined as persistent blood flow or pressure within the sac on imaging (Table III).
Type 1 endoleaks may be treated with an aortic extension cuff. Type 2 endoleaks may be treated with coil embolisation or laparoscopic Laparoscopic
A minimally-invasive surgical or diagnostic procedure that uses a flexible endoscope (laparoscope) to view and operate on structures in the abdomen.
Mentioned in: Obstetrical Emergencies clip ligation ligation /li·ga·tion/ (li-ga´shun) the application of a ligature.
tubal ligation sterilization of the female by constricting, severing, or crushing the uterine tubes. of offending lumbar or inferior mesenteric arteries. Type 3 endoleaks may be treated with an additional stentgraft. Delayed type 4 endoleak has been linked to increased porosity associated with e-PTFE stentgrafts, namely Excluder ('sac hygroma').
The Eurostar registry revealed primary endoleak rates of 16% (43% type 1, 35% type 2, 7% type 3, 8% type 4 and 5% type 5). A total of 75% of endoleaks resolved after a month, and 16% of patients developed a new (secondary) endoleak after a month. (2)
An endoleak is suspected if there is sac expansion of over 5 mm or sac volume increase over 5% on imaging. Type 1 and type 3 endoleaks should be treated expeditiously. Type 2 endoleaks unassociated with sac expansion can be monitored by more frequent imaging.
A recent systematic review of 163 studies showed a pooled estimate of 10.5% for type 1 endoleaks and 13.7% for type 2, 3 and 4 endoleaks combined (annual incidence of 10.2%). (3)
This is defined as a greater than 5 mm change in stentgraft position. The incidence is 2-2.9%. Higher rates are associated with oversizing (by over 20%), with infrarenal fixation (10.9%, v. 2.1% for suprarenal fixation) and aortic neck angulation angulation /an·gu·la·tion/ (ang?gu-la´shun)
1. formation of a sharp obstructive bend, as in the intestine, ureter, or similar tubes.
2. deviation from a straight line, as in a badly set bone. of over 60 degrees. (4)
Graft limb occlusion
The overall incidence was approximately 2.8% (2.7% at 1 year, 4.1% at 2 years and 5.5% at 3 years)4 and was associated with older generation unprotected stentgrafts. Graft limb kinking was more likely with distal aortic diameters under 16 mm and 'bail-out' stenting was invariably in·var·i·a·ble
Not changing or subject to change; constant.
The incidence in the Eurostar registry, a large multinational European database formed in 1996, was 3.7%. Patients at risk were women with angulated aortic necks treated by less experienced teams. Interestingly, there was no relationship between decrease in aneurysm diameter and stentgraft kinking. (5)
This is usually associated with severe aortic neck angulation.
The cumulative risk of rupture is approximately 1-2% per annum with a resultant operative mortality of 40-50%. Significant risk factors for rupture are type 1 endoleak, type 3 endoleak, stentgraft migration and post-procedure stentgraft kinking. (6)
The evidence for EVAR
The EVAR I study compared EVAR and OR in good-risk patients aged over 60 years, with AAAs over 5.5 cm. The EVAR 30-day mortality was approximately 1.7% v. 4.7% for OR, p = 0.009. At 12 months there was negligible difference in the health-related quality of life between EVAR and OR groups. At 4 years, the all-cause mortality was similar in both groups (28%), although the aneurysm-related mortality was significantly better for EVAR (4% v. 7%, p = 0.04). At 4 years the mean hospital costs were higher with EVAR, and the reintervention rate was also higher with EVAR. (7,8)
The DREAM trial had similar 30-day mortality results in favour of EVAR. At 2 years, however, there was no difference in the all-cause and aneurysm-related mortality between the two groups. (9,10)
The EVAR II study compared EVAR with no intervention in patients considered unfit for OR. The 30-day mortality in the EVAR group was 9%. Mortality at 4 years was 64% (similar for both groups). There was no difference in the all-cause and aneurysm-related mortality rates between the two groups. (11)
A recent analysis of 5 USA multicentre device trials showed no overall survival advantage for EVAR compared with OR in high-risk patients at 4 years (55% v. 66%). There was also no difference in the aneurysm-related mortality rate. (12)
Much of the data and experience with stentgrafts come from the Eurostar registry. Successful stentgraft deployment was achieved in 97%; the 30-day mortality was 2.9% (3.4% in the initial experience).
The cumulative annual risk of conversion to OR was 2.1% (1.9% at 30 days and 11.7% at 4 years); contributing significant risk factors were type 1, 2 and 3 endoleaks, stentgraft migration and graft kinking. (6) The cumulative risk for a secondary reintervention (usually endovascular) was 12% at 1 year, 24% at 2 years, and 35% at 3 years. (4)
Concerns of renal impairment with the use of suprarenal stent fixation have not materialised. However, patients with renal impairment undergoing EVAR have a higher mortality rate compared with patients with normal renal function.
The Eurostar registry has certainly informed and influenced the evolution of stentgraft technology, device-related complications having decreased from 21.7% to 7.3% between 1994 and 2000. Current devices are associated with fewer secondary interventions, less conversions to OR and less aneurysm-related mortality.
A recent US study showed a better anatomical profile (suitability) for EVAR at 5 years, with improved survival and freedom from rupture for patients with small AAAs (< 5.0 cm), compared with medium and large aneurysms (> 5.5 cm).13 However, current concerns with long-term durability, the results of the US and UK small AAA studies showing no benefit of OR compared with imaging surveillance alone, (14,15) and lack of significant differences in secondary interventions, endoleaks and stentgraft migration rates between small and large AAAs preclude EVAR for small AAA in current practice.
In a recent systematic EVAR review, the 30-day mortality rates, annual rupture rates (0.6%), and total number of endoleaks all fell significantly with time. The results of new randomised Adj. 1. randomised - set up or distributed in a deliberately random way
irregular - contrary to rule or accepted order or general practice; "irregular hiring practices" controlled trials ('ACE' and 'OVER' trials) utilising current state-of-the-art stentgrafts are awaited.
The current consensus therefore advocates OR in young, fit patients (even despite suitable anatomy for EVAR) and EVAR in older, conventional ('good and intermediate') risk patients with suitable anatomy. Patients with significant medical co-morbidities should be optimised prior to EVAR. EVAR in a patient with a life expectancy of < 1 year cannot be justified on current evidence.
Endovascular repair of emergent or ruptured AAA (e-EVAR)
All stable patients presenting with suspected ruptured AAA should have a MDCTA to assess suitability for EVAR. Commercial stentgrafts of various diameters, lengths and configurations need to be readily available. A recent study showed that although 45.8% of patients with ruptured AAA had suitable anatomy for e-EVAR, the applicability rate was low. (14)
A recent Dutch study comparing e-EVAR with OR for ruptured AAA showed significant differences regarding mean operative times, mean blood losses, mean ICU stays and mean hospital stays in favour of e-EVAR. However, there were no differences in the 30-day mortality rates (31% in both groups), systemic complications or early and late reintervention rates. (17)
Expanded indications for aortic stentgrafting
* Juxtarenal, pararenal and suprarenal AAA (using fenestrated and branched stentgrafts).
* Thoracic endovascular aortic aneurysm repair (TEVAR TEVAR Thoracic Endovascular Aneurysm Repair ).
* Hybrid procedures (combined surgery and stentgrafting) for repair of thoraco-abdominal aortic aneurysms (TAAA TAAA Tucson Amateur Astronomy Association
TAAA Thoraco-Abdominal Aortic Aneurysm
TAAA Total Active Aircraft Authorization ).
* Hybrid procedures for repair of aortic arch aneurysms (including the 'stented elephant-trunk' technique) (Fig. 7).
[FIGURE 7 OMITTED]
* Acute and chronic type II aortic dissections.
* Treatment of penetrating aortic ulcers.
* Traumatic thoracic aortic rupture
* Thoracic aortic pseudo-aneurysm.
(1.) Rutherford RB. Vascular Surgery, 6th ed. Philadelphia: Elsevier Saunders, 2005.
(2.) Buth J, Laheij RJF. Early complications and endoleaks after endovascular abdominal aortic aneurysm repair: Report of a multicenter study. J Vasc Surg 2000; 31: 134-146.
(3.) Franks SC, Sutton AJ, Brown MJ, Sayers RD. Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg 2007; 33: 154-171.
(4.) Towne JB. Endovascular treatment of abdominal aortic aneurysm. Am J Surg 2005; 189: 140-149.
(5.) Fransen GA, Desgranges P, Laheij RJ, et al. Frequency, predictive factors, and consequences of stentgraft kinking following endovascular AAA repair. J Endovascular Ther 2003; 10(5): 913-918.
(6.) Vallabhaneni SR, Harris PL. Lessons learnt from the Eurostar registry on endovascular repair of abdominal aortic aneurysm. Eur J Rad 2001; 39: 34-41.
(7.) Greenhalgh RM, Brown LC, Epstein D, et al. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day mortality results. Lancet 2004; 364: 843-848.
(8.) Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomized controlled trial A randomized controlled trial (RCT) is a scientific procedure most commonly used in testing medicines or medical procedures. RCTs are considered the most reliable form of scientific evidence because it eliminates all forms of spurious causality. . Lancet 2005; 365: 2179-2186.
(9.) Endovascular aneurysm repair and outcome in patients unfit for open repair of abdominal aortic aneurysm (EVAR trial 2): randomized controlled trial. Lancet 2005; 365: 2187-2192.
(10.) Prinssen M, Verhoeven ELG ELG Early Learning Goals (education)
ELG Export-Led Growth
ELG Endoluminal Graft
ELG Effluent Limitation Guideline
ELG European Liaison Group
ELG Executive Level Group
ELG Engineering Log Generator , Buth J, et al. A randomized ran·dom·ize
tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es
To make random in arrangement, especially in order to control the variables in an experiment. trial comparing conventional and endovascular repair of abdominal aortic aneurysms. N Engl J Med 2004; 351: 1607-1618.
(11.) Blankensteijn JD, de Jong SECA SECA Solid State Energy Conversion Alliance
SECA Swiss Private Equity & Corporate Finance Association
SECA Southern Early Childhood Association
SECA Sulphur Emission Control Area
SECA Self-Employment Contributions Act of 1954 , Prinssen M van der Ham AC, Buth J, Dream Trial Group.Two year outcomes after conventional or endovascular repair of abdominal aortic aneurysms. N Engl J Med 2005; 352: 2398- 2405.
(12.) Sicard GA, Zwolak RM, Sidawy AN, White RA, Siami FS. Endovascular abdominal aortic aneurysm repair: Long-term outcome measures in patients at high risk for open surgery. J Vasc Surg 2006; 44: 229-236.
(13.) Zarins CK, Crabtree T, Bloch DA, Arko FR, Ouriel K, White RA. Endovascular aneurysm repair at 5 years: does aneurysm diameter predict outcome? J Vasc Surg 2006; 44: 920-930.
(14.) Lederle FA, Samuel EW, Jonhson GR, et al. Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1437-1444.
(15.) The UK Small Aneurysm trialists: Long-term outcome of immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 2002; 346: 1445-1452.
(16.) Hoornweg LL, Wisselink W, Vahl A, Balm R. The Amsterdam Acute Aneurysm trial: suitability and application rate for endovascular repair of ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 2007; 20: 1-5.
(17.) Visser JJ, Bosch JL, Hunink MGM MGM
in full Metro-Goldwyn-Mayer, Inc.
U.S. corporation and film studio. It was formed when the film distributor Marcus Loew, who bought Metro Pictures in 1920, merged it with the Goldwyn production company in 1924 and with Louis B. Mayer Pictures in 1925. , van Dijk CK, Hendriks JM, Poldermans D. Endovascular repair versus open surgery in patients with ruptured abdominal aortic aneurysms: clinical outcomes with 1 year follow-up. J Vasc Surg 2006; 44: 1148-1155.
In a nutshell
* Aortic stentgrafts have expanded the treatment options for repair of abdominal aortic aneurysms.
* Surgery and EVAR are complementary, not competitive, treatment strategies.
* Current stentgraft configuration for EVAR involves a modular, bifurcated, design. Thoracic stentgrafts employ a tube configuration, with current limitations involving obtaining an adequate seal in the aortic arch and bulky, rigid, delivery devices.
* Current limitations to EVAR include hostile proximal aortic neck anatomy, difficult iliac access, and small calibre vessels in females.
* EVAR in appropriate patients has excellent early and improving intermediate results. In experienced hands it is safe and effective.
* The magnitude of surgery may be reduced by the adjunctive use of aortic stentgrafts ('hybrid' procedures for complex aortic aneurysm repairs).
* EVAR, despite being minimally invasive, is not a lesser procedure. The magnitude of procedure-related complications rivals that associated with open surgery.
* In the long term, EVAR is more expensive than surgery.
* The long-term durability of aortic stentgrafts has yet to be defined.
* EVAR is less invasive, but patients require serial long-term follow-up and imaging surveillance, with increased probability of secondary reinterventions (approximately 40% are free of reinterventions at 5 years). This needs to be discussed with patients.
Table I. Prerequisites for successful EVAR * Successful stentgraft delivery and deployment * Adequate stentgraft fixation in normal arterial segments proximal and distal to an AAA (aortic and iliac 'seal' or landing zone) * Depressurisation of the aneurysmal sac with no type 1 or type 3 endoleaks * Stentgraft patency without significant twisting, kinking, migration, occlusion or graft sepsis Table II. Anatomical requirements for abdominal aortic stentgrafting * Infrarenal aortic neck length 20 mm (for infrarenal fixation) or 10-15 mm (for suprarenal fixation) * Infrarenal aortic neck diameter = 28 mm, with no more than 1-2 mm thrombus lining and < 3 mm diameter discrepancy at any point in the neck * Aortic neck angulation (junction between the aortic neck and the aneurysm) < 60 degrees (ideally < 40 degrees) * External iliac diameter [greater than or equal to] 7 mm (with extensively calcified vessels) or [greater than or equal to] 6 mm (with non-calcified vessels) * Iliac vessels without severe tortuosity, significant aneurysmal or occlusive disease Table III. A simple classification of endoleaks * Type 1: inadequate proximal or distal seal * Type 2: patient side branch (intercostals, lumbar, accessory renal, inferior mesenteric arteries, etc.) * Type 3: modular disconnection or fabric tear * Type 4: increased graft porosity * Type 5: indeterminate (endotension) pg314-318.indd 316
N G NAIDOO, MB ChB, FCS FCS - Frame Check Sequence (SA)
Head, Vascular Surgery, Department of Surgery, Groote Schuur Hospital This article or section needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article. , Cape Town
Nadraj Naidoo graduated from the University of Natal The University of Natal was a university in Natal, and later KwaZulu-Natal in South Africa. It was founded in 1910 as the Natal University College in Pietermaritzburg, and expanded to include a campus in Durban in 1931. , Durban. He did his surgical training at King Edward VIII Hospital and post-fellowship training in renal transplantation and vascular surgery in Durban. His interests include HIV-associated vasculopathy, Takayasu's disease and aorto-iliac disease.
STEVE BENINGFIELD, MB ChB, FFRad (D) SA
Professor, Radiology Division, Groote Schuur Hospital and University of Cape Town
“UCT” redirects here. For other uses, see UCT (disambiguation).
Steve Beningfield is a graduate from the University of Cape Town. He joined the Department of Radiology at Groote Schuur Hospital in 1983 and obtained the FFRad (D) SA in 1986. His special interests include interventional radiology, particularly hepatobiliary and vascular.