Tecan and pION Team up to Cost Effectively Screen Drug Permeability.DURHAM, N.C. -- Two world-renowned companies, Tecan AG and pION INC, have launched the PAMPA Explorer[TM], a new manual system for drug permeability screening using the Double-Sink[TM] parallel artificial membrane permeability assay (PAMPA). The PAMPA Explorer draws upon the combined expertise of both parties, providing the user with the product and support they need to succeed in today's highly competitive R&D environment. As the premier manufacturer of automated liquid handling workstations and multimode microplate readers, Tecan is supplying its new Infinite[TM] M200 plate reader for the system. Long recognized as "the A in ADME ADME Absorption, Distribution, Metabolism, and Excretion ADME Association of Destination Management Executives ADME Active Duty Medical Extension ", pION has commercialized PAMPA and developed applications that are highly correlated with Caco-2, gastrointestinal tract (GIT) and blood-brain barrier (BBB BBB A medium grade assigned to a debt obligation by a rating agency to indicate an adequate ability to pay interest and repay principal. However, adverse developments are more likely to impair this ability than would be the case for bonds rated A and above. ) permeation. The PAMPA Explorer is a manual, upgradeable entry-level PAMPA system featuring the Infinite M200 plate reader, capable of screening hundreds of compounds per day. The advanced quad4 monochromators[TM] technology in the Infinite M200 provides excellent sensitivity and allows the user to select any wavelength from UV to NIR, and to perform absorbance absorbance /ab·sor·bance/ (-sor´bans) 1. in analytical chemistry, a measure of the light that a solution does not transmit compared to a pure solution. Symbol . 2. , excitation and emission scans. Of course, the PAMPA Explorer can be upgraded to a fully automated Tecan Freedom EVO([R]) platform system when sample throughput increases. "Over the years we've invested heavily in developing new applications for our patented Double-Sink PAMPA that allows our licensed customers to conduct cost-effective screening prior to the more expensive cellular and in vivo GIT and BBB testing. We're excited about working with Tecan, who builds high quality and reliability into all its products. Tecan's first-class plate reader, the Infinite M200, is no exception," explains Dr. Alex Avdeef, pION CSO and President. Double-Sink PAMPA is an API-sparing technique that allows the user to identify the most promising leads well in advance of other cell-based methods. To see the PAMPA Explorer system in the USA, visit pION booth 2434 at AAPS AAPS American Association of Pharmaceutical Scientists AAPS Association of American Physicians and Surgeons AAPS Ann Arbor Public Schools AAPS American Association of Plastic Surgeons AAPS African Association of Political Science in San Diego, November 12-14, 2007. For more information about Tecan, please contact: Tecan Group Ltd. Seestrasse 103, CH-8708 Mannedorf Switzerland T +41 44 922 81 11, F +41 44 922 81 12 info@tecan.com, www.tecan.com For more information about pION, please contact: pION INC 5 Constitutional Way, Woburn, MA 01801 T +1 781 935 8939, F+1 781 935 8938 info@pion-inc.com, www.pion-inc.com About Tecan Tecan (www.tecan.com) is a leading global supplier of solutions for the biopharma, forensic and diagnostic industries. The company is a leader in the development, production and distribution of advanced automation and detection solutions for the world's leading life science laboratories. Through its REMP REMP Research, Engineering, Math and Physics (US NSA) subsidiary (www.remp.com), Tecan is the premier supplier of large-scale automated laboratory storage and logistics systems. Founded in Switzerland in 1980, the company has over 1100 employees, owns production, research and development sites in both North America and Europe and maintains a sales and service network in 52 countries. In 2006, Tecan achieved sales of CHF CHF In currencies, this is the abbreviation for the Swiss Franc. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. 405.9 million (USD USD In currencies, this is the abbreviation for the U.S. Dollar. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. 324.7 million; EUR EUR In currencies, this is the abbreviation for the Euro. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. 258.6 million). Shares of the Tecan Group are traded on the SWX Swiss Exchange SWX Swiss Exchange An all-electronic securities exchange formed from the 1995 merger of exchanges in Geneva, Basel, and Zurich. The exchange offers trading in equity securities, investment funds, exchange-traded funds, bonds, Eurobonds, and options. (TK: TECN/Reuters: TECZn.S/Valor: 1210019). About pION pION INC, located in Woburn, Mass., develops, manufactures, and provides analytical tools for the biotechnology and pharmaceutical industries. pION's line of products and laboratory services help increase the speed of compound screening while reducing the overall cost of drug discovery. pION tools provide characterization and prediction of absorption, permeability, solubility, dissolution, and other physicochemical physicochemical /phys·i·co·chem·i·cal/ (fiz?i-ko-kem´ik-il) pertaining to both physics and chemistry. phys·i·co·chem·i·cal adj. 1. Relating to both physical and chemical properties. and QSAR properties of chemical compounds. |
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