Targeted Molecular Diagnostics -TMD- Announces a Gene Sequencing Service for Mutation Detection in Retrospective or Current Studies.WESTMONT, Ill. -- Targeted Molecular Diagnostics (TMD TMD Temporomandibular Joint Dysfunction TMD Theater Missile Defense TMD Transmembrane Domain TMD Temporomandibular Disorder TMD Tuned Mass Damper TMD Toshiba Matsushita Display Technology Co., Ltd. ), an advanced, oncology focused, specialty laboratory that specializes in the application of molecular pathology, today introduced an additional service of gene sequencing in either paraffin-embedded blocks or frozen tissue samples. E[acute accent]"We are delighted to offer our sequencing capabilities on routinely processed material to pharmaceutical companies and to the oncology community," states Dr. Sarah Bacus, founder, president and Chief Executive Officer of TMD. "This additional service will further enhance our ability to assist our pharmaceutical and oncology clients in targeted drug development and in treatment. We are very proud to provide this valuable service knowing that it could directly influence the success of patient therapy." E[acute accent]Mutations in genes that are drug targets may be critical in determining whether a patient will respond to a particular targeted therapy. It is crucial to establish a correlation, if it exists, between gene mutation and responsiveness to therapy as early as possible in patient trials. A genotype-directed clinical trial could increase the number of responders for a particular targeted therapy. E[acute accent]Scientists at TMD have recently successfully validated the sequencing of mutations within two exons in the kinase domain of the human epidermal growth factor receptor This article is about a cell suface receptor. For estimated measure of kidney function (eGFR), see Glomerular filtration rate. The epidermal growth factor receptor (EGFR EGFR Epidermal Growth Factor Receptor (a kinase enzyme) EGFR Estimated Glomerular Filtration Rate ) gene. Substitution and deletion mutations within these exons have previously been shown to correlate with responsiveness of non-small cell lung cancer Lung Cancer, Non-Small Cell Definition Non-small cell lung cancer (NSCLC) is a disease in which the cells of the lung tissues grow uncontrollably and form tumors. Description There are two kinds of lung cancers, primary and secondary. (NSCLC NSCLC non (or cancer). NSCLC Non-small cell lung cancer, see there ) patients to treatment with gefitinib (Iressa(R)), an EGFR kinase inhibitor. Other gene mutations, such as hereditary breast cancer susceptibility genes BRCA BRCA One of two genes (designated BRCA1 and BRCA2) that help repair damage to DNA, but when inherited in a defective state increase the risk of breast and ovarian cancer. 1 and BRCA2, or frequently mutated oncogenes oncogenes 1. genes carried by tumor viruses that are directly and solely responsible for the neoplastic transformation of host cells. Many oncogenes function after integration into the DNA of the host cell and some up-regulate normal downstream host cell genes to cause neoplasia. such as Ras, can be analyzed in a similar manner. E[acute accent]TMD will prepare DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. from either frozen or paraffin-embedded tissue, design PCR PCR polymerase chain reaction. PCR abbr. polymerase chain reaction Polymerase chain reaction (PCR) primers specific for the exons (or other regions) of the gene of interest, amplify the DNA in a series of nested PCR reactions and sequence the 2nd round PCR products bidirectionally to identify any mutations present, using a capillary based, ABI Abi (ā`bī) [short for Abijah], in the Bible, King Hezekiah's mother. (Application Binary Interface) A specification for a specific hardware platform combined with the operating system. Prism(R) 3100-Avant Genetic Analyzer. Any mutations will be verified by sequencing normal tissue from the same patient. All of this can be done from the same samples that TMD receives for immunohistochemistry tests, thus obviating the need to send samples to multiple laboratories for analysis. Since TMD can use either paraffin embedded blocks or frozen tissue samples, sequencing can be done retrospectively on archived material or on current studies. E[acute accent]About Targeted Molecular Diagnostics, LLC E[acute accent]TMD is a privately held, advanced, highly innovative, oncology focused, specialty diagnostic laboratory. The company innovates the drug development process - from pre-clinical through Phase III - by providing guidance through biomarker expression analysis. TMD's scientists have unique understanding in cell signaling and in drug mechanisms of action which allow them to define subpopulations of tumors that will respond to targeted cancer therapies. Doing so enables the drug developer to increase the response rates of their therapeutic asset, greatly reduce the cost of clinical trials and minimize the time for regulatory approval. Additionally, by providing targeted diagnostic testing services to clinical laboratories, TMD catalyzes the adoption of innovative technologies. For more information please visit us at: www.tmdlab.com |
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