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Takara Bio Sheds Light on Anti-inflammatory Mechanism of Agaro-oligosaccharide.


Tokyo, Japan, Sept 9, 2005 - (JCNN JCNN Japan Corporate News Network ) - Takara Bio announced on September 8 the findings of its latest research on agaro-oligosaccharide, a major polysaccharide component of agar. The recent research found that the anti-inflammatory effect of agaro-oligosaccharide is triggered by the expression induction of heme oxygenase-1 (HO-1).

Further, the company confirmed that agaro-oligosaccharide can inhibit the generations of cyclooxygenase-2 (COX-2) and prostaglandin E synthase Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism. It generates prostaglandin E (PGE) from prostaglandin H2.

The synthase generating PGE2 is a membrane-associated protein also known as mPEGS-1[1].
, two enzymes required in the synthesis of prostaglandin E2 (PGE PGE Pacific Gas and Electric Company
PGE Portland General Electric
PGE Prostaglandin E
PGE Platinum Group Elements
PGE Pacific Great Eastern (Railroad)
PGE Phenyl Glycidyl Ether
PGE Perfect Girl Evolution
2), which is responsible for inducing inflammation and pains. Subsequently, agaro-oligosaccharide can exert an anti-inflammatory effect.

Takara Bio plans to present details of theses findings at the 64th Annual Meeting of the Japanese Cancer Association to be held in Sapporo from September 14 to 16.

Source: JCN JCN Japan Corporate News
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Publication:JCNN News Summaries
Date:Sep 10, 2005
Words:133
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